Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome - Test2 - elhamkhani - TriplyDB

Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome

Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome

http://www.wikidata.org/entity/Q30496828

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Pathophysiological power of improper tonic GABA(A) conductances in mature and immature models.Alterations of GABAergic signaling in autism spectrum disorders What can we learn about autism from studying fragile X syndrome?Conceptualizing neurodevelopmental disorders through a mechanistic understanding of fragile X syndrome and Williams syndrome Synaptic Plasticity, a Prominent Contributor to the Anxiety in Fragile X Syndrome Advances in the Understanding of the Gabaergic Neurobiology of FMR1 Expanded Alleles Leading to Targeted Treatments for Fragile X Spectrum Disorder Altered Neuronal and Circuit Excitability in Fragile X Syndrome.Emerging pharmacologic treatment options for fragile X syndrome Prenatal stress and inhibitory neuron systems: implications for neuropsychiatric disorders Fragile X syndrome and targeted treatment trials.The contribution of inhibitory interneurons to circuit dysfunction in Fragile X Syndrome GABAergic signaling as therapeutic target for autism spectrum disorders Functional regulation of GABAA receptors in nervous system pathologies Inhibition-Based Biomarkers for Autism Spectrum Disorder.Targeted pharmacological treatment of autism spectrum disorders: fragile X and Rett syndromes Therapeutic Strategies in Fragile X Syndrome: From Bench to Bedside and Back Review of targeted treatments in fragile X syndrome Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model.GABAB Receptor Agonist R-Baclofen Reverses Social Deficits and Reduces Repetitive Behavior in Two Mouse Models of Autism Translational regulation of NeuroD1 expression by FMRP: involvement in glutamatergic neuronal differentiation of cultured rat primary neural progenitor cells p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus GABA receptor subunit distribution and FMRP-mGluR5 signaling abnormalities in the cerebellum of subjects with schizophrenia, mood disorders, and autism.Emotion potentiated startle in fragile X syndrome.Deletion of Fmr1 alters function and synaptic inputs in the auditory brainstem.The GABA(A) receptor agonist THIP ameliorates specific behavioral deficits in the mouse model of fragile X syndrome.FMRP regulates neurotransmitter release and synaptic information transmission by modulating action potential duration via BK channels Circuit level defects in the developing neocortex of Fragile X mice.Identifying large-scale brain networks in fragile X syndrome.Tuftsin-driven experimental autoimmune encephalomyelitis recovery requires neuropilin-1.Acamprosate in a mouse model of fragile X syndrome: modulation of spontaneous cortical activity, ERK1/2 activation, locomotor behavior, and anxiety Psychiatric symptoms in boys with fragile X syndrome: a comparison with nonsyndromic autism spectrum disorder.Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives.Development of dendritic tonic GABAergic inhibition regulates excitability and plasticity in CA1 pyramidal neurons.Arbaclofen in fragile X syndrome: results of phase 3 trials Fragile X targeted pharmacotherapy: lessons learned and future directions.Effects of a social stimulus on gene expression in a mouse model of fragile X syndrome Deficient tonic GABAergic conductance and synaptic balance in the fragile X syndrome amygdala Protein kinase C regulates tonic GABA(A) receptor-mediated inhibition in the hippocampus and thalamus

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Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome

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2010 nî lūn-bûn

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Defective GABAergic neurotrans ...... se model of fragile X syndrome

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Defective GABAergic neurotrans ...... se model of fragile X syndrome

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JNEUROSCI.1714-10.2010

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Journal of Neuroscience

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Defective GABAergic neurotrans ...... se model of fragile X syndrome

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Brandon S Martin

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Jose Luis Olmos-Serrano

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Joshua G Corbin

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Molly M Huntsman

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Scott M Paluszkiewicz

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Walter E Kaufmann

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P2860

Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors

Altered synaptic plasticity in a mouse model of fragile X mental retardation

Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function

A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice

Advances in the treatment of fragile X syndrome

Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors

Neuroligin-2 deletion selectively decreases inhibitory synaptic transmission originating from fast-spiking but not from somatostatin-positive interneurons

Downregulation of tonic GABAergic inhibition in a mouse model of fragile X syndrome.

Critical period mechanisms in developing visual cortex

Metabotropic glutamate receptor activation regulates fragile x mental retardation protein and FMR1 mRNA localization differentially in dendrites and at synapses

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