about
Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's diseasePARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's diseaseBAD is a pro-survival factor prior to activation of its pro-apoptotic functionLeucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective functionLocalization of LRRK2 to membranous and vesicular structures in mammalian brainPharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease.Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activationNeuronal activity regulates hippocampal miRNA expressionNeurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.Identification and evaluation of NO-regulated genes by differential analysis of primary cDNA library expression (DAzLE).The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.Dynamic and redundant regulation of LRRK2 and LRRK1 expression.GTPase activity plays a key role in the pathobiology of LRRK2.Endonuclease G does not play an obligatory role in poly(ADP-ribose) polymerase-dependent cell death after transient focal cerebral ischemia.Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality.Potent neuroprotectants linked to bifunctional inhibitionFunctional identification of neuroprotective molecules.Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis.Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models.Role of AIF in caspase-dependent and caspase-independent cell death.LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization.Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological processes modulated by LRRK2 activity.What have genetically engineered mice taught us about ischemic injury?High-Content Genome-Wide RNAi Screen Reveals CCR3 as a Key Mediator of Neuronal Cell Death.Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death.Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons.Usp16: key controller of stem cells in Down syndromeAutophagy-mediated clearance of aggresomes is not a universal phenomenonOverexpression of Parkinson's Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein PathologyParthanatos: mitochondrial-linked mechanisms and therapeutic opportunities.LRRK2 pathobiology in Parkinson's disease.Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease.Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases.Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents.Relative sensitivity of parkin and other cysteine-containing enzymes to stress-induced solubility alterations.Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress.Neonatal stroke in mice causes long-term changes in neuronal Notch-2 expression that may contribute to prolonged injury.Toward the human cellular microRNAome.
P50
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P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Valina Dawson
@fr
Valina L Dawson
@nl
Valina L Dawson
@sl
Valina L. Dawson
@en
Valina L. Dawson
@es
type
label
Valina Dawson
@fr
Valina L Dawson
@nl
Valina L Dawson
@sl
Valina L. Dawson
@en
Valina L. Dawson
@es
altLabel
Valina Dawson
@en
prefLabel
Valina Dawson
@fr
Valina L Dawson
@nl
Valina L Dawson
@sl
Valina L. Dawson
@en
Valina L. Dawson
@es
P106
P1153
7103259450
P21
P31
P496
0000-0002-2915-3970