Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease
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An early endosome regulator, Rab5b, is an LRRK2 kinase substratePumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levelsEmerging preclinical pharmacological targets for Parkinson's diseaseHeterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implicationsParkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synucleinThe LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancerPhosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPasesLeucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brainAlleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegenerationA visual review of the interactome of LRRK2: Using deep-curated molecular interaction data to represent biology.Ribosomal proteins: functions beyond the ribosomeMiR-223 regulates the differentiation of immature neuronsGenome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways.Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo.A genome-wide copy number variant study of suicidal behavior.Lovastatin protects neurite degeneration in LRRK2-G2019S parkinsonism through activating the Akt/Nrf pathway and inhibiting GSK3β activity.Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression.Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expressionComputational approaches for understanding the diagnosis and treatment of Parkinson's disease.Activation of Pim Kinases Is Sufficient to Promote Resistance to MET Small-Molecule Inhibitors.dbPAF: an integrative database of protein phosphorylation in animals and fungiDecoding Parkinson's Disease Pathogenesis: The Role of Deregulated mRNA Translation.G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons.LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction.Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activityA genome-wide association study in multiple system atrophy.LRRK2 Inhibits FAK Activity by Promoting FERM-mediated Autoinhibition of FAK and Recruiting the Tyrosine Phosphatase, SHP-2The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research.Endogenous Leucine-Rich Repeat Kinase 2 Slows Synaptic Vesicle Recycling in Striatal Neurons.Overexpression of Parkinson's Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein PathologyInteraction of LRRK2 with kinase and GTPase signaling cascadesLRRK2 pathobiology in Parkinson's disease.Invited review: decoding the pathophysiological mechanisms that underlie RNA dysregulation in neurodegenerative disorders: a review of the current state of the art.Synphilin-1 attenuates mutant LRRK2-induced neurodegeneration in Parkinson's disease models.Therapeutic strategies in Parkinson's disease: what we have learned from animal models.Function and dysfunction of leucine-rich repeat kinase 2 (LRRK2): Parkinson's disease and beyondCellular processes associated with LRRK2 function and dysfunctionAlterations in late endocytic trafficking related to the pathobiology of LRRK2-linked Parkinson's disease.Targeting the Autophagy/Lysosomal Degradation Pathway in Parkinson's Disease.LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?
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P2860
Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease
description
2014 nî lūn-bûn
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2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2014 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
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2014年论文
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name
Ribosomal protein s15 phosphor ...... eration in Parkinson's disease
@ast
Ribosomal protein s15 phosphor ...... eration in Parkinson's disease
@en
Ribosomal protein s15 phosphor ...... eration in Parkinson's disease
@en-gb
Ribosomal protein s15 phosphor ...... eration in Parkinson's disease
@nl
type
label
Ribosomal protein s15 phosphor ...... eration in Parkinson's disease
@ast
Ribosomal protein s15 phosphor ...... eration in Parkinson's disease
@en
Ribosomal protein s15 phosphor ...... eration in Parkinson's disease
@en-gb
Ribosomal protein s15 phosphor ...... eration in Parkinson's disease
@nl
prefLabel
Ribosomal protein s15 phosphor ...... eration in Parkinson's disease
@ast
Ribosomal protein s15 phosphor ...... eration in Parkinson's disease
@en
Ribosomal protein s15 phosphor ...... eration in Parkinson's disease
@en-gb
Ribosomal protein s15 phosphor ...... eration in Parkinson's disease
@nl
P2093
P2860
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P3181
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Ribosomal protein s15 phosphor ...... eration in Parkinson's disease
@en
P2093
Byoung Dae Lee
Ho Chul Kang
Ian Martin
Jeannette Stankowski
Jin-Chong Xu
Jungwoo Wren Kim
Manoj Kumar
Shaida A Andrabi
Yulan Xiong
P2860
P304
P3181
P356
10.1016/J.CELL.2014.01.064
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P50
P577
2014-04-10T00:00:00Z