Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis
about
SAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S E2s to ubiquitylate β-TrCP1 via K11-linkage for degradationInactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma.Identification of RING-box 2 as a potential target for combating colorectal cancer growth and metastasis.Ubiquitination by SAG regulates macrophage survival/death and immune response during infection.Inactivation of Sag/Rbx2/Roc2 e3 ubiquitin ligase triggers senescence and inhibits kras-induced immortalizationThe neddylation-cullin 2-RBX1 E3 ligase axis targets tumor suppressor RhoB for degradation in liver cancer.Regulation of the DNA damage response by ubiquitin conjugation.Erbin is a novel substrate of the Sag-βTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesisRegulator of cullins-1 expression knockdown suppresses the malignant progression of muscle-invasive transitional cell carcinoma by regulating mTOR/DEPTOR pathway.Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells.The NAE inhibitor pevonedistat interacts with the HDAC inhibitor belinostat to target AML cells by disrupting the DDR.Blockage of neddylation modification stimulates tumor sphere formation in vitro and stem cell differentiation and wound healing in vivoA unified Bayesian semiparametric approach to assess discrimination ability in survival analysis.Depletion of SAG/RBX2 E3 ubiquitin ligase suppresses prostate tumorigenesis via inactivation of the PI3K/AKT/mTOR axis.The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor.RNF7 knockdown inhibits prostate cancer tumorigenesis by inactivation of ERK1/2 pathway.SCF ubiquitin ligase-targeted therapies.DEPTOR has growth suppression activity against pancreatic cancer cells.The Neddylation Inhibitor Pevonedistat (MLN4924) Suppresses and Radiosensitizes Head and Neck Squamous Carcinoma Cells and Tumors.Neddylation E2 UBE2F Promotes the Survival of Lung Cancer Cells by Activating CRL5 to Degrade NOXA via the K11 Linkage.SAG/Rbx2-Dependent Neddylation Regulates T-Cell Responses.SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization.MLN4924 neddylation inhibitor promotes cell death in paclitaxel-resistant human lung adenocarcinoma cells.Protein neddylation and its alterations in human cancers for targeted therapy.Inhibition of the NEDD8 conjugation pathway induces calcium-dependent compensatory activation of the pro-survival MEK/ERK pathway in acute lymphoblastic leukemia.Regulation of Mammalian DNA Replication via the Ubiquitin-Proteasome System.
P2860
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P2860
Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis
description
2014 nî lūn-bûn
@nan
2014 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Inactivation of SAG/RBX2 E3 ub ...... G12D-driven lung tumorigenesis
@ast
Inactivation of SAG/RBX2 E3 ub ...... G12D-driven lung tumorigenesis
@en
type
label
Inactivation of SAG/RBX2 E3 ub ...... G12D-driven lung tumorigenesis
@ast
Inactivation of SAG/RBX2 E3 ub ...... G12D-driven lung tumorigenesis
@en
prefLabel
Inactivation of SAG/RBX2 E3 ub ...... G12D-driven lung tumorigenesis
@ast
Inactivation of SAG/RBX2 E3 ub ...... G12D-driven lung tumorigenesis
@en
P2093
P2860
P356
P1476
Inactivation of SAG/RBX2 E3 ub ...... G12D-driven lung tumorigenesis
@en
P2093
Dafydd Thomas
David G Beer
Dongping Wei
Guoan Chen
Mingjia Tan
P2860
P304
P356
10.1172/JCI70297
P407
P577
2014-01-16T00:00:00Z