Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity.
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Therapeutic Targeting of AutophagyCalpain mobilizes Atg9/Bif-1 vesicles from Golgi stacks upon autophagy induction by thapsigargin.p62 plays a protective role in the autophagic degradation of polyglutamine protein oligomers in polyglutamine disease model flies.Autophagy Constitutes a Protective Mechanism against Ethanol Toxicity in Mouse Astrocytes and NeuronsAntagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy.Calpastatin inhibits motor neuron death and increases survival of hSOD1(G93A) mice.Common disease signatures from gene expression analysis in Huntington's disease human blood and brainβ Cell-specific increased expression of calpastatin prevents diabetes induced by islet amyloid polypeptide toxicity.Lysosomal membrane permeabilization in cell death: new evidence and implications for health and disease.Discovery of Therapeutic Approaches for Polyglutamine Diseases: A Summary of Recent Efforts.Huntington's Disease: Calcium Dyshomeostasis and Pathology ModelsNovel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease.Effect and mechanism of calpains on pediatric lobar pneumonia.Autophagy in stress and disease.Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat.Proteostasis in Huntington's disease: disease mechanisms and therapeutic opportunities.Autophagy in Negative-Strand RNA Virus Infection.Regulatory role of calpain in neuronal death.Potential Alzheimer's Disease Therapeutics Among Weak Cysteine Protease Inhibitors Exhibit Mechanistic Differences Regarding Extent of Cathepsin B Up-Regulation and Ability to Block Calpain.Crosstalk Between Mammalian Autophagy and the Ubiquitin-Proteasome System
P2860
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P2860
Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity.
description
2014 nî lūn-bûn
@nan
2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Calpain inhibition mediates au ...... gainst polyglutamine toxicity.
@ast
Calpain inhibition mediates au ...... gainst polyglutamine toxicity.
@en
type
label
Calpain inhibition mediates au ...... gainst polyglutamine toxicity.
@ast
Calpain inhibition mediates au ...... gainst polyglutamine toxicity.
@en
prefLabel
Calpain inhibition mediates au ...... gainst polyglutamine toxicity.
@ast
Calpain inhibition mediates au ...... gainst polyglutamine toxicity.
@en
P2093
P2860
P50
P356
P1476
Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity
@en
P2093
C J O'Kane
D C Rubinsztein
F M Menzies
S Imarisio
T Ricketts
Z W Green-Thompson
P2860
P2888
P304
P356
10.1038/CDD.2014.151
P577
2014-09-26T00:00:00Z