Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy. - Test2 - elhamkhani - TriplyDB

Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy.

Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy.

http://www.wikidata.org/entity/Q36577891

about

Autophagy in Neurodegenerative Diseases and Metal Neurotoxicity Exploring Braak's Hypothesis of Parkinson's Disease.Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson's disease Non-cell-autonomous Neurotoxicity of α-synuclein Through Microglial Toll-like Receptor 2 Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model.Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril.Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans.Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons.Toll-like receptor 2 is increased in neurons in Parkinson's disease brain and may contribute to alpha-synuclein pathology.The implication of neuronimmunoendocrine (NIE) modulatory network in the pathophysiologic process of Parkinson's disease.Cellular models for Parkinson's disease.mTOR Signaling in Parkinson's Disease.Defects in trafficking bridge Parkinson's disease pathology and genetics.Animal models of α-synucleinopathy for Parkinson disease drug development.Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype.Toll Like Receptor 4 Affects the Cerebral Biochemical Changes Induced by MPTP Treatment.Identification of Insulin Receptor Splice Variant B in Neurons by in situ Detection in Human Brain Samples.An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2.Toll-Like Receptor 2 Signaling and Current Approaches for Therapeutic Modulation in Synucleinopathies.UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation Microglia Response During Parkinson's Disease: Alpha-Synuclein Intervention

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P2860

Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy.

http://www.wikidata.org/entity/Q36577891

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Antagonizing Neuronal Toll-lik ...... pathy by Activating Autophagy.

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Antagonizing Neuronal Toll-lik ...... pathy by Activating Autophagy.

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Antagonizing Neuronal Toll-lik ...... pathy by Activating Autophagy.

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J.CELREP.2015.09.044

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Antagonizing Neuronal Toll-lik ...... pathy by Activating Autophagy.

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Anthony Adame

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Brian Spencer

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Changyoun Kim

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He-Jin Lee

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Hyung-Koo Kim

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Klodjan Stafa

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Margarita Trejo

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P2860

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

Toll-like receptors control autophagy.

Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity.

ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo.

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

α-Synucleinopathy phenotypes.

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771-782

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4

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Eliezer Masliah

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2015-10-13T00:00:00Z

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283207851

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26489461

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Toll-like receptor

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4752835

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