Differential degradation of amyloid beta genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme.
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A comparative analysis of the aggregation behavior of amyloid-β peptide variantsThe catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesisSystemic catabolism of Alzheimer's Abeta40 and Abeta42.Mechanisms of enzymatic degradation of amyloid Beta microfibrils generating nanofilaments and nanospheres related to cytotoxicity.Iowa variant of familial Alzheimer's disease: accumulation of posttranslationally modified AbetaD23N in parenchymal and cerebrovascular amyloid depositsHuman ApoE Isoforms Differentially Modulate Glucose and Amyloid Metabolic Pathways in Female Brain: Evidence of the Mechanism of Neuroprotection by ApoE2 and Implications for Alzheimer's Disease Prevention and Early InterventionMatrix metalloproteinase 2 (MMP-2) degrades soluble vasculotropic amyloid-beta E22Q and L34V mutants, delaying their toxicity for human brain microvascular endothelial cellsAbeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species.Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid depositionPolymorphic triple beta-sheet structures contribute to amide hydrogen/deuterium (H/D) exchange protection in the Alzheimer amyloid beta42 peptideDifferential cerebral deposition of IDE and NEP in sporadic and familial Alzheimer's diseaseHereditary cerebral hemorrhage with amyloidosis-Dutch type.Mechanism of cerebral beta-amyloid angiopathy: murine and cellular models.Protofibril assemblies of the arctic, Dutch, and Flemish mutants of the Alzheimer's Abeta1-40 peptidePresenilin-1 280Glu-->Ala mutation alters C-terminal APP processing yielding longer abeta peptides: implications for Alzheimer's diseaseTg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy.The bradykinin B1 receptor regulates Aβ deposition and neuroinflammation in Tg-SwDI mice.The association between small vessel infarcts and the activities of amyloid-β peptide degrading proteases in apolipoprotein E4 allele carriers.Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}In vivo Differential Brain Clearance and Catabolism of Monomeric and Oligomeric Alzheimer's Aβ proteinMolecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's diseaseThe senescence hypothesis of disease progression in Alzheimer disease: an integrated matrix of disease pathways for FAD and SAD.Metabolism of amyloid β peptide and pathogenesis of Alzheimer's disease.Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin.Pharmacogenomics of angiotensin receptor/neprilysin inhibitor and its long-term side effects.Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production.Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers.Evaluation of neprilysin sequence variation in relation to CSF β-Amyloid levels and Alzheimer disease riskE22Δ Mutation in Amyloid β-Protein Promotes β-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity.Dutch and Arctic mutant peptides of beta amyloid(1-40) differentially affect the FGF-2 pathway in brain endothelium.Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo.Familial Danish dementia: co-existence of Danish and Alzheimer amyloid subunits (ADan AND A{beta}) in the absence of compact plaques.Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation.Understanding the roles of mutations in the amyloid precursor protein in Alzheimer disease.Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays.Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology.Complementary distributions of amyloid-beta and neprilysin in the brains of dogs and cats.Multiple functions of insulin-degrading enzyme: a metabolic crosslight?
P2860
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P2860
Differential degradation of amyloid beta genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme.
description
2003 nî lūn-bûn
@nan
2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Differential degradation of am ...... e by insulin-degrading enzyme.
@ast
Differential degradation of am ...... e by insulin-degrading enzyme.
@en
type
label
Differential degradation of am ...... e by insulin-degrading enzyme.
@ast
Differential degradation of am ...... e by insulin-degrading enzyme.
@en
prefLabel
Differential degradation of am ...... e by insulin-degrading enzyme.
@ast
Differential degradation of am ...... e by insulin-degrading enzyme.
@en
P2093
P2860
P356
P1476
Differential degradation of am ...... e by insulin-degrading enzyme.
@en
P2093
Blas Frangione
Eduardo M Castano
Frances Prelli
Jorge Ghiso
Jose L Affranchino
Laura Morelli
Ramiro Llovera
Silvia A Gonzalez
P2860
P304
23221-23226
P356
10.1074/JBC.M300276200
P407
P577
2003-04-14T00:00:00Z