Rationalizing the chemical space of protein-protein interaction inhibitors.
about
Surfing the Protein-Protein Interaction Surface Using Docking Methods: Application to the Design of PPI InhibitorsExpanding the number of 'druggable' targets: non-enzymes and protein-protein interactionsChemical libraries dedicated to protein-protein interactionsDeconstruction of a Nutlin: Dissecting the Binding Determinants of a Potent Protein–Protein Interaction InhibitorTyrosine kinase syk non-enzymatic inhibitors and potential anti-allergic drug-like compounds discovered by virtual and in vitro screeningEnabling large-scale design, synthesis and validation of small molecule protein-protein antagonistsBcL-xL conformational changes upon fragment binding revealed by NMRProbing the probes: fitness factors for small molecule tools.Identification of a small molecule that modulates platelet glycoprotein Ib-von Willebrand factor interactionA leap into the chemical space of protein-protein interaction inhibitorsTargeting protein-protein interactions as an anticancer strategyPeptides and peptidomimetics as immunomodulators.Plane of best fit: a novel method to characterize the three-dimensionality of molecules2P2Idb: a structural database dedicated to orthosteric modulation of protein-protein interactions.Design of libraries targeting protein-protein interfaces.Computational analysis of protein-protein interfaces involving an alpha helix: insights for terphenyl-like molecules binding.2P2I HUNTER: a tool for filtering orthosteric protein-protein interaction modulators via a dedicated support vector machine.Balancing novelty with confined chemical space in modern drug discovery.Identification of Small-Molecule Frequent Hitters from AlphaScreen High-Throughput Screens.Structure-based design of small-molecule protein-protein interaction modulators: the story so far.Focused chemical libraries--design and enrichment: an example of protein-protein interaction chemical space.A unified lead-oriented synthesis of over fifty molecular scaffolds.TNF superfamily protein-protein interactions: feasibility of small- molecule modulationComputational and biophysical approaches to protein-protein interaction inhibition of Plasmodium falciparum AMA1/RON2 complex.Medicinal chemistry for 2020Pharmacological manipulation of transcription factor protein-protein interactions: opportunities and obstaclesMTiOpenScreen: a web server for structure-based virtual screening.Imbalance in chemical space: How to facilitate the identification of protein-protein interaction inhibitors.PocketQuery: protein-protein interaction inhibitor starting points from protein-protein interaction structure.iPPI-DB: an online database of modulators of protein-protein interactions.Inhibition of protein-protein interaction of HER2-EGFR and HER2-HER3 by a rationally designed peptidomimetic.Local cAMP signaling in disease at a glanceThe p53-MDM2/MDMX axis - A chemotype perspective.Structure-activity relationships of peptidomimetics that inhibit PPI of HER2-HER3.Inhibitors of the interactions between HIV-1 IN and the cofactor LEDGF/p75.Module assembly for designing multivalent mid-sized inhibitors of protein-protein interactions.Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.Computational analysis of calculated physicochemical and ADMET properties of protein-protein interaction inhibitorsSystematic Targeting of Protein-Protein InteractionsMedicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction.
P2860
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P2860
Rationalizing the chemical space of protein-protein interaction inhibitors.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Rationalizing the chemical space of protein-protein interaction inhibitors.
@ast
Rationalizing the chemical space of protein-protein interaction inhibitors.
@en
type
label
Rationalizing the chemical space of protein-protein interaction inhibitors.
@ast
Rationalizing the chemical space of protein-protein interaction inhibitors.
@en
prefLabel
Rationalizing the chemical space of protein-protein interaction inhibitors.
@ast
Rationalizing the chemical space of protein-protein interaction inhibitors.
@en
P2093
P1433
P1476
Rationalizing the chemical space of protein-protein interaction inhibitors.
@en
P2093
Anne-Claude Camproux
Bruno O Villoutreix
Christelle H Reynès
P304
P356
10.1016/J.DRUDIS.2009.11.007
P577
2009-12-05T00:00:00Z