Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions - Test2 - elhamkhani - TriplyDB

Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions

Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions

http://www.wikidata.org/entity/Q27003966

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Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction Networks Small Molecule Targeting of Protein-Protein Interactions through Allosteric Modulation of Dynamics Design and Implementation of the International Genetics and Translational Research in Transplantation Network NMR approaches in structure-based lead discovery: recent developments and new frontiers for targeting multi-protein complexes Inhibitors of difficult protein-protein interactions identified by high-throughput screening of multiprotein complexes.Identification of fragments targeting an alternative pocket on HIV-1 gp41 by NMR screening and similarity searching.Pharmacological chaperone for α-crystallin partially restores transparency in cataract models Improved assays for determining the cytosolic access of peptides, proteins, and their mimetics.Anti-obesity phenotypic screening looking to increase OBR cell surface expression.Development of a capillary electrophoresis platform for identifying inhibitors of protein-protein interactions Detection of protein-small molecule binding using a self-referencing external cavity laser biosensor.Focused chemical libraries--design and enrichment: an example of protein-protein interaction chemical space.A rapid and sensitive high-throughput screening method to identify compounds targeting protein-nucleic acids interactions.Twisted amide electrophiles enable cyclic peptide sequencing.The CCL2 chemokine is a negative regulator of autophagy and necrosis in luminal B breast cancer cells Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?DARC 2.0: Improved Docking and Virtual Screening at Protein Interaction Sites Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors.Identification of Binding Targets of a Pyrrole-Imidazole Polyamide KR12 in the LS180 Colorectal Cancer Genome The non-detergent sulfobetaine-201 acts as a pharmacological chaperone to promote folding and crystallization of the type II TGF-β receptor extracellular domain CryptoSite: Expanding the Druggable Proteome by Characterization and Prediction of Cryptic Binding Sites.Matching the power of high throughput screening to the chemical diversity of natural products High capacity nanoporous silicon carrier for systemic delivery of gene silencing therapeutics.Pharos: Collating protein information to shed light on the druggable genome.Targeted gene silencing of CCL2 inhibits triple negative breast cancer progression by blocking cancer stem cell renewal and M2 macrophage recruitment.Oncogenic protein interfaces: small molecules, big challenges.Drugging the 'undruggable' cancer targets.Computational analysis of calculated physicochemical and ADMET properties of protein-protein interaction inhibitors The effect of NOD2 on the microbiota in Crohn's disease.Peptidyl-Proline Isomerases (PPIases): Targets for Natural Products and Natural Product-Inspired Compounds.A Novel Inhibitor of Homeodomain Interacting Protein Kinase 2 Mitigates Kidney Fibrosis through Inhibition of the TGF-β1/Smad3 Pathway.Sequence context and crosslinking mechanism affect the efficiency of in vivo capture of a protein-protein interaction Comprehensive experimental and computational analysis of binding energy hot spots at the NF-κB essential modulator/IKKβ protein-protein interface.Target (In)Validation: A Critical, Sometimes Unheralded, Role of Modern Medicinal Chemistry.HAMS: High-Affinity Mass Spectrometry Screening. A High-Throughput Screening Method for Identifying the Tightest-Binding Lead Compounds for Target Proteins with No False Positive Identifications Drug-Like Protein-Protein Interaction Modulators: Challenges and Opportunities for Drug Discovery and Chemical Biology.A Synthetic Loop Replacement Peptide That Blocks Canonical NF-κB Signaling.Beyond the hundred dollar genome--drug discovery futures.Global profiling of lysine reactivity and ligandability in the human proteome.As Technologies for Nucleotide Therapeutics Mature, Products Emerge.

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P2860

Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions

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2013 nî lūn-bûn

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2013 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2013年の論文

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Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions

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Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions

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Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions

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Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions

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Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions

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Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions

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Chemical Biology and Drug Design

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Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions

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Jason E. Gestwicki

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Leah N. Makley

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P2860

Towards a proteome-scale map of the human protein–protein interaction network

Structural conservation of druggable hot spots in protein-protein interfaces

Direct inhibition of the NOTCH transcription factor complex

A small molecule that binds Hedgehog and blocks its signaling in human cells

Fine-tuning multiprotein complexes using small molecules

Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity

Targeting survivin in cancer

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone

Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery

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scholarly article

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2739486

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10.1111/CBDD.12066

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3531880

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