Formation and toxicity of soluble polyglutamine oligomers in living cells.
about
Quantitative fluorescence loss in photobleaching for analysis of protein transport and aggregation.Resveratrol: A Focus on Several Neurodegenerative DiseasesMapping the structure of amyloid nucleation precursors by protein engineering kinetic analysis.Modulation of the stability of amyloidogenic precursors by anion binding strongly influences the rate of amyloid nucleation.Ubiquitination is involved in secondary growth, not initial formation of polyglutamine protein aggregates in C. elegans.Huntingtin fragments and SOD1 mutants form soluble oligomers in the cellETS1 regulates the expression of ATXN2.The relationship between aggregation and toxicity of polyglutamine-containing ataxin-3 in the intracellular environment of Escherichia coli.The L-cysteine desulfurase NFS1 is localized in the cytosol where it provides the sulfur for molybdenum cofactor biosynthesis in humansPhotobleaching methods to study Golgi complex dynamics in living cells.Changes in BiP availability reveal hypersensitivity to acute endoplasmic reticulum stress in cells expressing mutant huntingtin.Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's diseaseThe Toxic Effects of Pathogenic Ataxin-3 Variants in a Yeast Cellular ModelHuntingtin aggregation kinetics and their pathological role in a Drosophila Huntington's disease modelDisruption of Purkinje cell function prior to huntingtin accumulation and cell loss in an animal model of Huntington disease.siRNA screen identifies QPCT as a druggable target for Huntington's disease.α-Synuclein oligomers and clinical implications for Parkinson disease.Age-Dependent Resistance to Excitotoxicity in Htt CAG140 Mice and the Effect of Strain Background.Ubiquilin/Dsk2 promotes inclusion body formation and vacuole (lysosome)-mediated disposal of mutated huntingtinPhysical chemistry of polyglutamine: intriguing tales of a monotonous sequence.Protein oxidation in Huntington disease.SpatTrack: an imaging toolbox for analysis of vesicle motility and distribution in living cells.Huntington's Disease: Mechanisms of Pathogenesis and Therapeutic Strategies.Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress.Nanoparticulate strategies for the treatment of polyglutamine diseases by halting the protein aggregation process.Detecting soluble polyQ oligomers and investigating their impact on living cells using split-GFPTracking protein aggregation and mislocalization in cells with flow cytometry.Examination of Ataxin-3 (atx-3) Aggregation by Structural Mass Spectrometry Techniques: A Rationale for Expedited Aggregation upon Polyglutamine (polyQ) Expansion.Proteostasis of Huntingtin in Health and DiseaseAggregation behavior of chemically synthesized, full-length huntingtin exon1.Modeling Huntington disease in Drosophila: Insights into axonal transport defects and modifiers of toxicity.Polyglutamine toxicity in yeast uncovers phenotypic variations between different fluorescent protein fusions.Discovery of Small Molecules that Induce the Degradation of Huntingtin.Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein.
P2860
Q21284320-107551AC-545A-4F1A-855E-7F3C598F2F5FQ26800952-B8C1C139-6AC1-42CA-A1CE-F76C73A753C4Q30009502-00DC41A6-0810-4577-BD97-42C0B93078DDQ30009585-C558F2F1-BCA3-4D94-8512-3982EFB26908Q30515046-924951E3-19B6-4369-8F94-9811B9BD77C3Q34328850-07882325-6D16-4E52-AFE9-466E600FEA16Q34390181-E3E7F8EA-7FE5-41BC-9E0E-1B5D0C9E00D7Q34517343-049659E1-E34B-40FD-85BD-440CE092357CQ34674294-360FBF76-6148-40A7-9977-5B0420DD8314Q35057502-7953B4EF-206C-4B76-A072-BC0BBB9D1DA7Q35227496-8C255481-F5C6-46BC-A30C-33794B82E593Q35645271-5937B83A-265E-46D8-9714-4E398E3C747FQ35656171-5B0E7FD7-E831-4E0B-8F19-2975C8A8FC75Q35748307-14C16949-A412-4562-9E7D-4947E44EDB24Q36007592-A9A93F65-6C2D-46BD-8837-DCA6C4A9E50CQ36416732-27F731B5-34C0-4DBE-AE9C-921ED2CBE367Q36718306-3076F3BF-B73D-46BB-815B-B5EDF3E7A304Q36984277-B9139FD8-E3EE-42DD-83C6-E0CE17C62E4EQ37052727-812B0D92-7277-42F8-AF7C-580B16DB66DBQ37981477-FBF18473-86DE-4018-9069-9770F79A2927Q37999718-448C46D6-1201-4312-90A5-9E17940DA482Q38954364-BB2776F4-9AC1-45DA-B0CB-1D39AE3466C5Q39035495-7C07D61F-A1BD-433D-89D0-61E4B1581FF8Q39064401-6527EE52-3D09-4172-9FE9-FDE9CDA58BB3Q39112084-5F9E4E90-9F9D-4096-9714-24A908562E1BQ39146006-5F06AF88-106B-4720-8008-659A1325B20FQ39377946-746BECA3-39A6-4DB6-8433-CCE7CC64813CQ40433494-51D9F131-432E-4169-8AB9-CFC1B98BF6EBQ41183326-C519F449-BED7-4815-97DC-4FC9664BE9F4Q41513084-B3B665D9-28FA-4776-8C5D-17FA1D380C3FQ41880469-2A267A49-451B-43EE-9021-D117FE6DDA67Q45298390-E62CCA82-A7D6-4B7A-8996-9C1AB2AAC7E0Q45303178-41134D93-8261-4E4F-A9C6-7379363A548EQ46236725-E10D1EB2-CC38-4DDB-BADA-2E2C3647F17C
P2860
Formation and toxicity of soluble polyglutamine oligomers in living cells.
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Formation and toxicity of soluble polyglutamine oligomers in living cells.
@ast
Formation and toxicity of soluble polyglutamine oligomers in living cells.
@en
type
label
Formation and toxicity of soluble polyglutamine oligomers in living cells.
@ast
Formation and toxicity of soluble polyglutamine oligomers in living cells.
@en
prefLabel
Formation and toxicity of soluble polyglutamine oligomers in living cells.
@ast
Formation and toxicity of soluble polyglutamine oligomers in living cells.
@en
P2860
P1433
P1476
Formation and toxicity of soluble polyglutamine oligomers in living cells.
@en
P2093
Patrick Lajoie
P2860
P304
P356
10.1371/JOURNAL.PONE.0015245
P407
P577
2010-12-28T00:00:00Z