Is there a difference between leads and drugs? A historical perspective.
about
Nitrile-containing pharmaceuticals: efficacious roles of the nitrile pharmacophoreComputational drug design strategies applied to the modelling of human immunodeficiency virus-1 reverse transcriptase inhibitorsHit identification and optimization in virtual screening: practical recommendations based on a critical literature analysisBadapple: promiscuity patterns from noisy evidence.Inhibition of Mycobacterium-RmlA by Molecular Modeling, Dynamics Simulation, and Docking.Minimal Pharmacophoric Elements and Fragment Hopping, an Approach Directed at Molecular Diversity and Isozyme Selectivity. Design of Selective Neuronal Nitric Oxide Synthase InhibitorsMolecular docking and ligand specificity in fragment-based inhibitor discoveryA Structure-Based Approach to Ligand Discovery for 2 C -Methyl- d -erythritol-2,4-cyclodiphosphate Synthase: A Target for Antimicrobial Therapy †Docking for fragment inhibitors of AmpC -lactamaseMolecular Shape and Medicinal Chemistry: A PerspectiveExperimental and computational active site mapping as a starting point to fragment-based lead discoveryDesign of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisationQuantitative estimation of pesticide-likeness for agrochemical discoveryConsensus Diversity Plots: a global diversity analysis of chemical librariesOptimal assignment methods for ligand-based virtual screeningLarge scale study of multiple-molecule queriesEnhancing hit identification in Mycobacterium tuberculosis drug discovery using validated dual-event Bayesian modelsMeta-analysis of molecular property patterns and filtering of public datasets of antimalarial “hits” and drugsSmall-molecule inhibitors of protein-protein interactions: progressing towards the dreamA poke in the eye: inhibiting HIV-1 protease through its flap-recognition pocketTargeting Non-Catalytic Cysteine Residues Through Structure-Guided Drug DiscoveryLabel free fragment screening using surface plasmon resonance as a tool for fragment finding - analyzing parkin, a difficult CNS targetDocking Screens for Novel Ligands Conferring New Biology.A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open-access computational tool.The pK(a) Distribution of Drugs: Application to Drug DiscoveryVirtual fragment screening: an exploration of various docking and scoring protocols for fragments using Glide.A minimalist approach to fragment-based ligand design using common rings and linkers: application to kinase inhibitors.A kinase-focused compound collection: compilation and screening strategy.An ultraefficient affinity-based high-throughout screening process: application to bacterial cell wall biosynthesis enzyme MurF.Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening.Lead-like, drug-like or "Pub-like": how different are they?Strategies to search and design stabilizers of protein-protein interactions: a feasibility study.Screening library evolution through automation of solution preparation.Lessons learnt from assembling screening libraries for drug discovery for neglected diseases.FAF-Drugs2: free ADME/tox filtering tool to assist drug discovery and chemical biology projects.A practical method for targeted library design balancing lead-like properties with diversity.Recent advances in computer-aided drug design.One-pot, three-component, domino Heck-aza-Michael approach to libraries of functionalized 1,1-dioxido-1,2-benzisothiazoline-3-acetic acidsPhysiochemical property space distribution among human metabolites, drugs and toxins.The acid-base profile of a contemporary set of drugs: implications for drug discovery.
P2860
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P2860
Is there a difference between leads and drugs? A historical perspective.
description
2001 nî lūn-bûn
@nan
2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Is there a difference between leads and drugs? A historical perspective.
@ast
Is there a difference between leads and drugs? A historical perspective.
@en
type
label
Is there a difference between leads and drugs? A historical perspective.
@ast
Is there a difference between leads and drugs? A historical perspective.
@en
prefLabel
Is there a difference between leads and drugs? A historical perspective.
@ast
Is there a difference between leads and drugs? A historical perspective.
@en
P2093
P356
P1476
Is there a difference between leads and drugs? A historical perspective.
@en
P2093
P304
P356
10.1021/CI010366A
P577
2001-09-01T00:00:00Z