A library of spirooxindoles based on a stereoselective three-component coupling reaction.
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Identification of Novel Epoxide Inhibitors of Hepatitis C Virus Replication Using a High-Throughput ScreenA systems biology approach to dissection of the effects of small bicyclic peptidomimetics on a panel of saccharomyces cerevisiae mutants.Jeffamine derivatized TentaGel beads and poly(dimethylsiloxane) microbead cassettes for ultrahigh-throughput in situ releasable solution-phase cell-based screening of one-bead-one-compound combinatorial small molecule librariesStereoselective synthesis of spirooxindole amides through nitrile hydrozirconationSolid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like librarySmall molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles.Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries.Construction of a spirooxindole amide library through nitrile hydrozirconation-acylation-cyclization cascade.Bio-inspired synthesis yields a tricyclic indoline that selectively resensitizes methicillin-resistant Staphylococcus aureus (MRSA) to β-lactam antibioticsCatalytic enantioselective 1,3-dipolar cycloadditions of azomethine ylides for biology-oriented synthesis.Natural products synthesis: enabling tools to penetrate Nature's secrets of biogenesis and biomechanism.Diversity-oriented synthesis as a tool for chemical genetics.Asymmetric multicomponent reactions (AMCRs): the new frontier.Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitorsStrategies for the enantioselective synthesis of spirooxindoles.Acylideneoxoindoles: a new class of reversible inhibitors of human transglutaminase 2.Terminating Catalytic Asymmetric Heck Cyclizations by Stereoselective Intramolecular Capture of η-Allylpalladium Intermediates: Total Synthesis of (-)-Spirotryprostatin B and Three Stereoisomers.Highly efficient construction of bisspirooxindoles containing vicinal spirocenters through an organocatalytic modified Feist-Bénary reaction.Control of remote stereochemistry in the synthesis of spirocyclic oxindoles: vinylogous organocascade catalysis.Construction of bispirooxindoles containing three quaternary stereocentres in a cascade using a single multifunctional organocatalyst.Synthesis and antifungal activities of novel polyheterocyclic spirooxindole derivatives.NHC-catalyzed [4+2] cycloaddition reactions for the synthesis of 3'-spirocyclic oxindoles via a C-F bond cleavage protocol.Diversity-driven and facile 1,3-dipolar cycloaddition to access dispirooxindole-imidazolidine scaffolds.Engaging Allene-Derived Zwitterions in an Unprecedented Mode of Asymmetric [3+2]-Annulation Reaction.Diastereoselective tandem oxidation/Michael/aldol reaction: unprecedented formation of dispirocyclopentanebisoxindoles and dispiro[acenaphthylene-1,1'-cyclopentane-3',1''-acenaphthylene]-2,2''diones.Total synthesis and biological evaluation of spirotryprostatin A analogs.Nine-step total synthesis of (-)-strychnofoline.The asymmetric synthesis of polycyclic 3-spirooxindole alkaloids via the cascade reaction of 2-isocyanoethylindoles.A tandem Prins spirocyclization for the stereoselective synthesis of tetrahydrospiro[chroman-2,4'-pyran] derivatives.Conjugate umpolung of β,β-disubstituted enals by dual catalysis with an N-heterocyclic carbene and a Brønsted acid: facile construction of contiguous quaternary stereocenters.Phosphine-catalyzed Rauhut-Currier domino reaction: a facile strategy for the construction of carbocyclic spirooxindoles skeletons.Phosphine-catalyzed domino reaction: an efficient method for the synthesis of highly functionalized spirooxazolines.Multicomponent reaction to construct spirocyclic oxindoles with a Michael (triple Michael)/cyclization cascade sequence as the key step.An efficient one pot regioselective synthesis of a 3,3'-spiro-phosphonylpyrazole-oxindole framework via base mediated [1,3]-dipolar cycloaddition reaction of the Bestmann-Ohira reagent with methyleneindolinones.Organocatalytic enantioselective construction of multi-functionalized spiro oxindole dienes.The utilization of spirocyclic scaffolds in novel drug discovery.An Asymmetric Diels-Alder Reaction Catalyzed by Chiral Phosphate Magnesium Complexes: Highly Enantioselective Synthesis of Chiral Spirooxindoles
P2860
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P2860
A library of spirooxindoles based on a stereoselective three-component coupling reaction.
description
2004 nî lūn-bûn
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2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年學術文章
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name
A library of spirooxindoles based on a stereoselective three-component coupling reaction.
@ast
A library of spirooxindoles based on a stereoselective three-component coupling reaction.
@en
type
label
A library of spirooxindoles based on a stereoselective three-component coupling reaction.
@ast
A library of spirooxindoles based on a stereoselective three-component coupling reaction.
@en
prefLabel
A library of spirooxindoles based on a stereoselective three-component coupling reaction.
@ast
A library of spirooxindoles based on a stereoselective three-component coupling reaction.
@en
P2093
P356
P1476
A library of spirooxindoles based on a stereoselective three-component coupling reaction
@en
P2093
Christopher S Neumann
Michael M-C Lo
Satoshi Nagayama
Stuart L Schreiber
P304
16077-16086
P356
10.1021/JA045089D
P407
P577
2004-12-01T00:00:00Z