Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors
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Catalytic asymmetric synthesis of biologically important 3-hydroxyoxindoles: an updateChemical Variations on the p53 Reactivation ThemeTransient Protein States in Designing Inhibitors of the MDM2-p53 InteractionDiscovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical DevelopmentEnergetic Landscape of MDM2-p53 Interactions by Computational Mutagenesis of the MDM2-p53 InteractionDiaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2-p53 and MDMX-p53 protein-protein interactions†Electronic supplementary information (ESI) available: Experimental details for compound synthesis, analytical data for all compounds and inDiscovery of 4-((3'R,4'S,5'R)-6″-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2″-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3″-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine DoubleSAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regressionSearching for Dual Inhibitors of the MDM2-p53 and MDMX-p53 Protein-Protein Interaction by a Scaffold-Hopping Approach.Small-molecule MDM2-p53 inhibitors: recent advances.A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice.Additive-assisted regioselective 1,3-dipolar cycloaddition of azomethine ylides with benzylideneacetoneSmall-molecule control of intracellular protein levels through modulation of the ubiquitin proteasome systemResistance acquisition to MDM2 inhibitors.Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapy: Progress and Challenges.Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction.Reviving the guardian of the genome: Small molecule activators of p53.Development of a novel immunoassay to detect interactions with the transactivation domain of p53: application to screening of new drugsDesign of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannich ring-opening-cyclization reaction mechanism in spiro-oxindoles.Titanium(IV)-catalyzed stereoselective synthesis of spirooxindole-1-pyrrolines.Counterion effects in the catalytic stereoselective synthesis of 2,3'-pyrrolidinyl spirooxindoles.Targeting oncoproteins for degradation by small molecules in myeloid leukemia.Catalytic enantioselective cascade Michael/cyclization reaction of 3-isothiocyanato oxindoles with exocyclic α,β-unsaturated ketones en route to 3,2'-pyrrolidinyl bispirooxindoles.Organocatalytic [3 + 2] cycloaddition of oxindole-based azomethine ylides with 3-nitrochromenes: a facile approach to enantioenriched polycyclic spirooxindole-chromane adducts.Cerium oxide-catalyzed multicomponent condensation approach to spirooxindoles in water.Small Molecule Modulators of RING-Type E3 Ligases: MDM and Cullin Families as Targets.
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Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 03 May 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors
@en
Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors.
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type
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Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors
@en
Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors.
@nl
prefLabel
Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors
@en
Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors.
@nl
P2093
P2860
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P1476
Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors
@en
P2093
Denzil Bernard
Donna McEachern
Jean-Christophe Carry
Jeffrey R Deschamps
Jianfeng Lu
Philippe Ochsenbein
Shanghai Yu
Shaomeng Wang
P2860
P304
P356
10.1021/JA3125417
P407
P577
2013-05-03T00:00:00Z