Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult.
about
Dequalinium-induced protofibril formation of alpha-synucleinThe H50Q mutation enhances α-synuclein aggregation, secretion, and toxicityDorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosisElectron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi's Concept (Szeged) till Novel Approaches to Boost Mitochondrial BioenergeticsThe contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's diseaseα-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson's diseaseProtein-metal interactions of calmodulin and alpha-synuclein monitored by selective noncovalent adduct protein probing mass spectrometry.Rapamycin improves motor function, reduces 4-hydroxynonenal adducted protein in brain, and attenuates synaptic injury in a mouse model of synucleinopathyalpha-Synuclein affects the MAPK pathway and accelerates cell death.Insights into the effects of alpha-synuclein expression and proteasome inhibition on glutathione metabolism through a dynamic in silico model of Parkinson's disease: validation by cell culture data.Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases.Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathySoluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction.Gamma-synuclein promotes cancer cell survival and inhibits stress- and chemotherapy drug-induced apoptosis by modulating MAPK pathways.Failure of the ubiquitin-proteasome system in Parkinson's disease.Disentangling the relationship between lewy bodies and nigral neuronal loss in Parkinson's disease.Alpha-synuclein aggregation induced by brief ischemia negatively impacts neuronal survival in vivo: a study in [A30P]alpha-synuclein transgenic mouseExpression of mutant alpha-synuclein modulates microglial phenotype in vitroOxidative stress in neurodegenerationAutophagy in dementias.Targeted Overexpression of α-Synuclein by rAAV2/1 Vectors Induces Progressive Nigrostriatal Degeneration and Increases Vulnerability to MPTP in MouseMechanism of neurodegenerative disease: role of the ubiquitin proteasome system.The cellular prion protein (PrP(C)): its physiological function and role in diseaseO-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's diseaseOgg1 null mice exhibit age-associated loss of the nigrostriatal pathway and increased sensitivity to MPTP.Vesicular uptake blockade generates the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde in PC12 cells: relevance to the pathogenesis of Parkinson's disease.Microglial activation and antioxidant responses induced by the Parkinson's disease protein α-synuclein.Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification.alpha-Synuclein: a therapeutic target for Parkinson's disease?Parkinson's disease and enhanced inflammatory response.Alpha-synuclein and Parkinson's disease: a proteomic view.Peroxidase mechanism of lipid-dependent cross-linking of synuclein with cytochrome C: protection against apoptosis versus delayed oxidative stress in Parkinson disease.Targeting the progression of Parkinson's disease.Role of synucleins in Alzheimer's disease.Molecular mechanisms of alpha-synuclein neurodegeneration.Mitochondrial trafficking of APP and alpha synuclein: Relevance to mitochondrial dysfunction in Alzheimer's and Parkinson's diseases.Mitochondrial proteomics as a selective tool for unraveling Parkinson's disease pathogenesis.The Relationship between Parkin and Protein Aggregation in Neurodegenerative Diseases.Oxidative stress in genetic mouse models of Parkinson's disease.The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans.
P2860
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P2860
Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult.
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Effect of the overexpression o ...... cell susceptibility to insult.
@ast
Effect of the overexpression o ...... cell susceptibility to insult.
@en
type
label
Effect of the overexpression o ...... cell susceptibility to insult.
@ast
Effect of the overexpression o ...... cell susceptibility to insult.
@en
prefLabel
Effect of the overexpression o ...... cell susceptibility to insult.
@ast
Effect of the overexpression o ...... cell susceptibility to insult.
@en
P2093
P1476
Effect of the overexpression o ...... cell susceptibility to insult.
@en
P2093
P304
P356
10.1046/J.1471-4159.2001.00149.X
P407
P577
2001-02-01T00:00:00Z