Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis
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A virtual screen discovers novel, fragment-sized inhibitors of Mycobacterium tuberculosis InhAInhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamidesDesign and Synthesis of Aryl Ether Inhibitors of theBacillus AnthracisEnoyl-ACP ReductaseHow Much Binding Affinity Can be Gained by Filling a Cavity?A Slow, Tight Binding Inhibitor of InhA, the Enoyl-Acyl Carrier Protein Reductase from Mycobacterium tuberculosisStructural and Enzymatic Analyses Reveal the Binding Mode of a Novel Series of Francisella tularensis Enoyl Reductase (FabI) InhibitorsPyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhAA machine learning-based method to improve docking scoring functions and its application to drug repurposingDrug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosisThe Mycobacterium tuberculosis drugome and its polypharmacological implicationsOutcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop.MycPermCheck: the Mycobacterium tuberculosis permeability prediction tool for small molecules.Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitorsCharacterization of the enzymes encoded by the anthrose biosynthetic operon of Bacillus anthracis.Phosphorylation of enoyl-acyl carrier protein reductase InhA impacts mycobacterial growth and survival.Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of Mycobacterium tuberculosisDirect inhibitors of InhA are active against Mycobacterium tuberculosis.Analysis of Enoyl-Acyl Carrier Protein Reductase Structure and Interactions Yields an Efficient Virtual Screening Approach and Suggests a Potential Allosteric Site.Computer-Aided Design of Orally Bioavailable Pyrrolidine Carboxamide Inhibitors of Enoyl-Acyl Carrier Protein Reductase of Mycobacterium tuberculosis with Favorable Pharmacokinetic Profiles.Evolution of a thienopyrimidine antitubercular relying on medicinal chemistry and metabolomics insights.Targeting the formation of the cell wall core of M. tuberculosis.Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor.Recent advances in the design and synthesis of heterocycles as anti-tubercular agents.Enoyl acyl carrier protein reductase inhibitors: a patent review (2006 - 2010).Targeting InhA, the FASII enoyl-ACP reductase: SAR studies on novel inhibitor scaffolds.Recent advances in inhibitors of bacterial fatty acid synthesis type II (FASII) system enzymes as potential antibacterial agents.Mycobacterium tuberculosis enoyl-acyl carrier protein reductase inhibitors as potential antituberculotics: development in the past decade.Recent Advances and Structural Features of Enoyl-ACP Reductase Inhibitors of Mycobacterium tuberculosis.Key Structures and Interactions for Binding of Mycobacterium tuberculosis Protein Kinase B Inhibitors from Molecular Dynamics Simulation.Insights into the bonding pattern for characterizing the open and closed state of the substrate-binding loop in Mycobacterium tuberculosis InhA.Preparation of alginate-chitosan-cyclodextrin micro- and nanoparticles loaded with anti-tuberculosis compounds.New structural classes of antituberculosis agents.Discovery of novel InhA reductase inhibitors: application of pharmacophore- and shape-based screening approach.Identification of Middle Chain Fatty Acyl-CoA Ligase Responsible for the Biosynthesis of 2-Alkylmalonyl-CoAs for Polyketide Extender Unit.Design, Synthesis, Toxicity Estimation and Molecular Docking Studies of N-(furan-2-yl)-1-(5-substituted) phenyl-1,3,4-oxadiazol-2-yl) methanimine as Antitubercular Agents.Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach.Pyrrolyl Pyrazoline Carbaldehydes as Enoyl-ACP Reductase Inhibitors: Design, Synthesis and Antitubercular Activity.Cell wall permeability assisted virtual screening to identify potential direct InhA inhibitors of Mycobacterium tuberculosis and their biological evaluation.Design, synthesis, and pharmacological evaluation of fluorinated azoles as anti-tubercular agents.Evaluation of the inhibitory activity of (aza)isoindolinone-type compounds: toward in vitro InhA action, Mycobacterium tuberculosis growth and mycolic acid biosynthesis.
P2860
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P2860
Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis
description
2006 nî lūn-bûn
@nan
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Pyrrolidine carboxamides as a ...... rom Mycobacterium tuberculosis
@ast
Pyrrolidine carboxamides as a ...... rom Mycobacterium tuberculosis
@en
Pyrrolidine carboxamides as a ...... om Mycobacterium tuberculosis.
@nl
type
label
Pyrrolidine carboxamides as a ...... rom Mycobacterium tuberculosis
@ast
Pyrrolidine carboxamides as a ...... rom Mycobacterium tuberculosis
@en
Pyrrolidine carboxamides as a ...... om Mycobacterium tuberculosis.
@nl
prefLabel
Pyrrolidine carboxamides as a ...... rom Mycobacterium tuberculosis
@ast
Pyrrolidine carboxamides as a ...... rom Mycobacterium tuberculosis
@en
Pyrrolidine carboxamides as a ...... om Mycobacterium tuberculosis.
@nl
P2093
P2860
P356
P1476
Pyrrolidine carboxamides as a ...... rom Mycobacterium tuberculosis
@en
P2093
Paul R Ortiz de Montellano
Robert Stroud
P2860
P304
P356
10.1021/JM060715Y
P407
P50
P577
2006-10-01T00:00:00Z