Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development - Test2 - elhamkhani - TriplyDB

Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development

Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development

http://www.wikidata.org/entity/Q33350164

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Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells Chemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative Medicine ADP-ribosyltransferases and poly ADP-ribosylation ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells Pharmacologic modulation of serine/threonine phosphorylation highly sensitizes PHEO in a MPC cell and mouse model to conventional chemotherapy Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Catenin Degradation-Competent Axin Puncta PARP inhibitor treatment in ovarian and breast cancer PARP inhibition: PARP1 and beyond Hypermetabolism, hyperphagia, and reduced adiposity in tankyrase-deficient mice.Destruction of a destructor: a new avenue for cancer therapeutics targeting the Wnt pathway Poly(ADP-ribosylation) is present in murine sciatic nerve fibers and is altered in a Charcot-Marie-Tooth-1E neurodegenerative model.Evolutionary history of the poly(ADP-ribose) polymerase gene family in eukaryotes.Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis.Proteasome regulation by ADP-ribosylation Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs.Exon 1 disruption alters tissue-specific expression of mouse p53 and results in selective development of B cell lymphomas Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression.Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth Tissue-specific roles of Axin2 in the inhibition and activation of Wnt signaling in the mouse embryo.Analysis of poly(ADP-Ribose) polymerases in Arabidopsis telomere biology.The Drosophila tankyrase regulates Wg signaling depending on the concentration of Daxin.XAV939-mediated ARTD activity inhibition in human MB cell lines.The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation Dual Roles for Membrane Association of Drosophila Axin in Wnt Signaling.E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling.Wnt pathway activation by ADP-ribosylation.The ADP-ribose polymerase Tankyrase regulates adult intestinal stem cell proliferation during homeostasis in Drosophila The expanding field of poly(ADP-ribosyl)ation reactions. 'Protein Modifications: Beyond the Usual Suspects' Review Series.Tankyrase inhibition aggravates kidney injury in the absence of CD2AP.Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms.Poly(ADP-ribose) polymerase inhibitors as promising cancer therapeutics.The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets.Telomere length in reproduction.Tankyrases as drug targets.Review of poly (ADP-ribose) polymerase (PARP) mechanisms of action and rationale for targeting in cancer and other diseases.Tankyrases: structure, function and therapeutic implications in cancer.New directions in poly(ADP-ribose) polymerase biology.Anti-TANKyrase weapons promote myelination.

P2860

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P2860

Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development

http://www.wikidata.org/entity/Q33350164

description

2008 nî lūn-bûn

@nan

2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development

@ast

Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development

@en

type

label

Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development

@ast

Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development

@en

prefLabel

Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development

@ast

Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development

@en

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JOURNAL.PONE.0002639

P1433

P1476

Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development

@en

P2093

Dena Yver

http://www.w3.org/2001/XMLSchema#string

Lino Tessarollo

http://www.w3.org/2001/XMLSchema#string

Samuel W Cushman

http://www.w3.org/2001/XMLSchema#string

Susan J Hsiao

http://www.w3.org/2001/XMLSchema#string

Y Jeffrey Chiang

http://www.w3.org/2001/XMLSchema#string

P2860

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres

The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)

Protein requirements for sister telomere association in human cells

Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase)

TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres

Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles

Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner

Resolution of sister telomere association is required for progression through mitosis

Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction

P304

e2639

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1371/JOURNAL.PONE.0002639

http://www.w3.org/2001/XMLSchema#string

P407

P433

7

http://www.w3.org/2001/XMLSchema#string

P478

3

http://www.w3.org/2001/XMLSchema#string

P50

Richard J. Hodes

P577

2008-07-09T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

5239167

http://www.w3.org/2001/XMLSchema#string

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18612384

http://www.w3.org/2001/XMLSchema#string

P932

2441437

http://www.w3.org/2001/XMLSchema#string