IL-21 limits peripheral lymphocyte numbers through T cell homeostatic mechanisms
about
Pouring fuel on the fire: Th17 cells, the environment, and autoimmunityNew insights into the regulation of T cells by gamma(c) family cytokinesMapping quantitative trait loci for T lymphocyte subpopulations in peripheral blood in swine.Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice.An update on the use of NOD mice to study autoimmune (Type 1) diabetes.Aberrant ROCK activation promotes the development of type I diabetes in NOD miceCutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cellsInterleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models.Premature CD4+ T cell aging and its contribution to lymphopenia-induced proliferation of memory cells in autoimmune-prone non-obese diabetic miceAbrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVLDifferential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice.Post-operative infection and sepsis in humans is associated with deficient gene expression of γc cytokines and their apoptosis mediatorsIL-21R signaling is critical for induction of spontaneous experimental autoimmune encephalomyelitis.Interleukin-21 is required for the development of type 1 diabetes in NOD mice.Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3+ CD4+ T cells with limited suppressor activity.Loss of parity between IL-2 and IL-21 in the NOD Idd3 locusTargeting interleukin-21 in inflammatory diseases.No association observed between schizophrenia and non-HLA coeliac disease genes: integration with the initial MYO9B association with coeliac disease.Confirmation of an association between rs6822844 at the Il2-Il21 region and multiple autoimmune diseases: evidence of a general susceptibility locus.Cytokines and type 1 diabetes: a numbers gameInterleukin-21 receptor-mediated signals control autoreactive T cell infiltration in pancreatic islets.Co-expression of HLA-B7 and HLA-B27 alleles is associated with B7-restricted immunodominant responses following influenza infection.Interleukin-21 up-regulates interleukin-21R expression and interferon gamma production by CD8+ cells in SHIV-infected macaques.The PTPN22 1858T allele but not variants in the proximal promoter region of IL-21 gene is associated with the susceptibility to type 1 diabetes and the presence of autoantibodies in a Brazilian cohortPTPN2 attenuates T-cell lymphopenia-induced proliferation
P2860
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P2860
IL-21 limits peripheral lymphocyte numbers through T cell homeostatic mechanisms
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
IL-21 limits peripheral lymphocyte numbers through T cell homeostatic mechanisms
@ast
IL-21 limits peripheral lymphocyte numbers through T cell homeostatic mechanisms
@en
type
label
IL-21 limits peripheral lymphocyte numbers through T cell homeostatic mechanisms
@ast
IL-21 limits peripheral lymphocyte numbers through T cell homeostatic mechanisms
@en
prefLabel
IL-21 limits peripheral lymphocyte numbers through T cell homeostatic mechanisms
@ast
IL-21 limits peripheral lymphocyte numbers through T cell homeostatic mechanisms
@en
P2860
P1433
P1476
IL-21 limits peripheral lymphocyte numbers through T cell homeostatic mechanisms
@en
P2093
Nora E Sarvetnick
Shrimati Datta
P2860
P356
10.1371/JOURNAL.PONE.0003118
P407
P577
2008-09-05T00:00:00Z