The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892. - Test2 - elhamkhani - TriplyDB

The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892.

The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892.

http://www.wikidata.org/entity/Q33392888

about

Radical SAM-mediated methylation reactions Radical-mediated enzymatic methylation: a tale of two SAMS Structural Characterization of OxyD, a Cytochrome P450 Involved in -Hydroxytyrosine Formation in Vancomycin Biosynthesis A hybrid NRPS-PKS gene cluster related to the bleomycin family of antitumor antibiotics in Alteromonas macleodii strains Evolution of High Cellulolytic Activity in Symbiotic Streptomyces through Selection of Expanded Gene Content and Coordinated Gene Expression Insights into an unusual nonribosomal peptide synthetase biosynthesis: identification and characterization of the GE81112 biosynthetic gene cluster.Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892 BlmB and TlmB provide resistance to the bleomycin family of antitumor antibiotics by N-acetylating metal-free bleomycin, tallysomycin, phleomycin, and zorbamycin.Classification of the adenylation and acyl-transferase activity of NRPS and PKS systems using ensembles of substrate specific hidden Markov models Comparative analysis of the biosynthetic gene clusters and pathways for three structurally related antitumor antibiotics: bleomycin, tallysomycin, and zorbamycin.Functional characterization of tlmH in Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insight into tallysomycin biosynthesis and affording a novel bleomycin analog Conserved biosynthetic pathways for phosalacine, bialaphos and newly discovered phosphonic acid natural products.Genomes to natural products PRediction Informatics for Secondary Metabolomes (PRISM)Functional characterization of tlmK unveiling unstable carbinolamide intermediates in the tallysomycin biosynthetic pathway.Radical S-adenosylmethionine enzymes.Structure and noncanonical chemistry of nonribosomal peptide biosynthetic machinery.Engineered production and evaluation of 6'-deoxy-tallysomycin H-1 revealing new insights into the structure-activity relationship of the anticancer drug bleomycin.A designer bleomycin with significantly improved DNA cleavage activity.Zorbamycin has a different DNA sequence selectivity compared with bleomycin and analogues.Manipulating Protein-Protein Interactions in Nonribosomal Peptide Synthetase Type II Peptidyl Carrier Proteins.MbtH homology codes to identify gifted microbes for genome mining.

P2860

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P2860

The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892.

http://www.wikidata.org/entity/Q33392888

description

2008 nî lūn-bûn

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2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2008 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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The biosynthetic gene cluster ...... myces flavoviridis ATCC 21892.

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The biosynthetic gene cluster ...... myces flavoviridis ATCC 21892.

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type

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The biosynthetic gene cluster ...... myces flavoviridis ATCC 21892.

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The biosynthetic gene cluster ...... myces flavoviridis ATCC 21892.

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The biosynthetic gene cluster ...... myces flavoviridis ATCC 21892.

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The biosynthetic gene cluster ...... myces flavoviridis ATCC 21892.

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Molecular BioSystems

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The biosynthetic gene cluster ...... myces flavoviridis ATCC 21892.

@en

P2093

Ben Shen

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Evelyn Wendt-Pienkowski

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Fan Yi

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Jane M Coughlin

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Liyan Wang

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Meifeng Tao

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Nicholas P George

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Tae-Jin Oh

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Ute Galm

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Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.

Specificity prediction of adenylation domains in nonribosomal peptide synthetases (NRPS) using transductive support vector machines (TSVMs)

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Peptide cyclization catalysed by the thioesterase domain of tyrocidine synthetase

Molecular cloning and analysis of the ergopeptine assembly system in the ergot fungus Claviceps purpurea

Bleomycin: new perspectives on the mechanism of action.

PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin.

The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit.

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77-90

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scholarly article

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10.1039/B814075H

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1

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5

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2008-11-12T00:00:00Z

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19081934

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