Engineered cystine knot peptides that bind alphavbeta3, alphavbeta5, and alpha5beta1 integrins with low-nanomolar affinity. - Test2 - elhamkhani - TriplyDB

Engineered cystine knot peptides that bind alphavbeta3, alphavbeta5, and alpha5beta1 integrins with low-nanomolar affinity.

Engineered cystine knot peptides that bind alphavbeta3, alphavbeta5, and alpha5beta1 integrins with low-nanomolar affinity.

http://www.wikidata.org/entity/Q33447473

about

Targeted contrast-enhanced ultrasound imaging of tumor angiogenesis with contrast microbubbles conjugated to integrin-binding knottin peptides.Applications of Yeast Surface Display for Protein Engineering Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th Critical Assessment of Techniques for Protein Structure Prediction Experiment CASP10 Accurate de novo design of hyperstable constrained peptides Peptide and protein-based inhibitors of HIV-1 co-receptors Preclinical molecular imaging of tumor angiogenesis.Interrogating and predicting tolerated sequence diversity in protein folds: application to E. elaterium trypsin inhibitor-II cystine-knot miniprotein An engineered knottin peptide labeled with 18F for PET imaging of integrin expression.Artificial disulfide-rich peptide scaffolds with precisely defined disulfide patterns and a minimized number of isomers.Cystine-knot peptides engineered with specificities for α(IIb)β(3) or α(IIb)β(3) and α(v)β(3) integrins are potent inhibitors of platelet aggregation.Functional mutation of multiple solvent-exposed loops in the Ecballium elaterium trypsin inhibitor-II cystine knot miniprotein.Phage display and molecular imaging: expanding fields of vision in living subjects.A Bioengineered Peptide that Localizes to and Illuminates Medulloblastoma: A New Tool with Potential for Fluorescence-Guided Surgical Resection Evaluation of a (64)Cu-labeled cystine-knot peptide based on agouti-related protein for PET of tumors expressing alphavbeta3 integrin A novel 18F-labeled two-helix scaffold protein for PET imaging of HER2-positive tumor Polycyclic peptide therapeutics.A radiofluorinated divalent cystine knot peptide for tumor PET imaging.A dual-labeled knottin peptide for PET and near-infrared fluorescence imaging of integrin expression in living subjects.Engineering agatoxin, a cystine-knot peptide from spider venom, as a molecular probe for in vivo tumor imaging PET imaging of tumor neovascularization in a transgenic mouse model with a novel 64Cu-DOTA-knottin peptide.Integrin targeted delivery of radiotherapeutics.PET Imaging of Integrin Positive Tumors Using F Labeled Knottin Peptides.Pharmacokinetically stabilized cystine knot peptides that bind alpha-v-beta-6 integrin with single-digit nanomolar affinities for detection of pancreatic cancer Stroma targeting nuclear imaging and radiopharmaceuticals.Tumor-targeting peptides from combinatorial libraries.CNS Anticancer Drug Discovery and Development Conference White Paper.Engineered knottin peptide enables noninvasive optical imaging of intracranial medulloblastoma.Protein scaffold-based molecular probes for cancer molecular imaging.99mTc-labeled cystine knot peptide targeting integrin αvβ6 for tumor SPECT imaging.Engineered cystine-knot miniproteins for diagnostic applications.Environmental-mediated drug resistance: a target for multiple myeloma therapy.Multimodality Imaging of Integrin α(v)β(3) Expression.Extracellular matrix and its receptors in Drosophila neural development About supramolecular systems for dynamically probing cells.Cystine-knot peptides: emerging tools for cancer imaging and therapy.Protein/peptide-based entry/fusion inhibitors as anti-HIV therapies: challenges and future direction.Affinity Maturation of a Cyclic Peptide Handle for Therapeutic Antibodies Using Deep Mutational Scanning.Plant cystine-knot peptides: pharmacological perspectives.Cellular uptake of a cystine-knot peptide and modulation of its intracellular trafficking.A chemically cross-linked knottin dimer binds integrins with picomolar affinity and inhibits tumor cell migration and proliferation.

P2860

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P2860

Engineered cystine knot peptides that bind alphavbeta3, alphavbeta5, and alpha5beta1 integrins with low-nanomolar affinity.

http://www.wikidata.org/entity/Q33447473

description

2009 nî lūn-bûn

@nan

2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Engineered cystine knot peptid ...... s with low-nanomolar affinity.

@ast

Engineered cystine knot peptid ...... s with low-nanomolar affinity.

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type

label

Engineered cystine knot peptid ...... s with low-nanomolar affinity.

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Engineered cystine knot peptid ...... s with low-nanomolar affinity.

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prefLabel

Engineered cystine knot peptid ...... s with low-nanomolar affinity.

@ast

Engineered cystine knot peptid ...... s with low-nanomolar affinity.

@en

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P2860

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Engineered cystine knot peptid ...... s with low-nanomolar affinity.

@en

P2093

Aron M Levin

http://www.w3.org/2001/XMLSchema#string

Frank V Cochran

http://www.w3.org/2001/XMLSchema#string

Jennifer R Cochran

http://www.w3.org/2001/XMLSchema#string

Richard H Kimura

http://www.w3.org/2001/XMLSchema#string

P2860

High-affinity single-domain binding proteins with a binary-code interface

A Dominant Conformational Role for Amino Acid Diversity in Minimalist Protein–Protein Interfaces

Structural and functional analyses of the Arg-Gly-Asp sequence introduced into human lysozyme

Integrins: versatility, modulation, and signaling in cell adhesion

The potential of cystine-knot microproteins as novel pharmacophoric scaffolds in oral peptide drug delivery

Squash inhibitors: from structural motifs to macrocyclic knottins

Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors

RGD and other recognition sequences for integrins

Requirement of vascular integrin alpha v beta 3 for angiogenesis

Sequence requirements of the GPNG beta-turn of the Ecballium elaterium trypsin inhibitor II explored by combinatorial library screening.

P304

359-369

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scholarly article

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10.1002/PROT.22441

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P433

2

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P478

77

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2009-11-01T00:00:00Z

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24437328

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19452550

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5792193

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