Synthesis of a resorcylic acid lactone (RAL) library using fluorous-mixture synthesis and profile of its selectivity against a panel of kinases.
about
Developing irreversible inhibitors of the protein kinase cysteinomeAutoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular processComprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.Total synthesis of LL-Z1640-2 utilizing a late-stage intramolecular Nozaki-Hiyama-Kishi reactionIsolation, semisynthesis, covalent docking and transforming growth factor beta-activated kinase 1 (TAK1)-inhibitory activities of (5Z)-7-oxozeaenol analoguesMacrocycles in new drug discovery.TAK1 selective inhibition: state of the art and future opportunities.Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors: synthesis, SAR analysis and biological evaluation.Rational design of resorcylic acid lactone analogues as covalent MNK1/2 kinase inhibitors by tuning the reactivity of an enamide Michael acceptor.Polyubiquitination of transforming growth factor β (TGFβ)-associated kinase 1 mediates nuclear factor-κB activation in response to different inflammatory stimuli.Kinase inhibition by deoxy analogues of the resorcylic lactone L-783277.Probing the influence of an allylic methyl group in zearalenone analogues on binding to Hsp90.Rhodamine F: a novel class of fluorous ponytailed dyes for bioconjugation.TAK1 inhibition in the DFG-out conformation.The JNK Signaling Pathway in Renal Fibrosis.Synthesis of deoxyelephantopin analogues.An efficient synthesis of an exo-enone analogue of LL-Z1640-2 and evaluation of its protein kinase inhibitory activities.Molecular editing of kinase-targeting resorcylic acid lactones (RAL): Fluoroenone RAL.
P2860
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P2860
Synthesis of a resorcylic acid lactone (RAL) library using fluorous-mixture synthesis and profile of its selectivity against a panel of kinases.
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
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2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
name
Synthesis of a resorcylic acid ...... ty against a panel of kinases.
@ast
Synthesis of a resorcylic acid ...... ty against a panel of kinases.
@en
type
label
Synthesis of a resorcylic acid ...... ty against a panel of kinases.
@ast
Synthesis of a resorcylic acid ...... ty against a panel of kinases.
@en
prefLabel
Synthesis of a resorcylic acid ...... ty against a panel of kinases.
@ast
Synthesis of a resorcylic acid ...... ty against a panel of kinases.
@en
P2093
P2860
P356
P1476
Synthesis of a resorcylic acid ...... ty against a panel of kinases.
@en
P2093
Gaëlle Valot
Pierre-Yves Dakas
Rajamalleswaramma Jogireddy
Sofia Barluenga
P2860
P304
11498-11506
P356
10.1002/CHEM.200901375
P407
P577
2009-11-01T00:00:00Z