about
Diversity-oriented synthetic strategies applied to cancer chemical biology and drug discoveryOxadiazole-Based Cell Permeable Macrocyclic Transition State Inhibitors of Norovirus 3CL ProteaseRing-Expansion Approach to Medium-Sized Lactams and Analysis of Their Medicinal Lead-Like Properties.Global analysis of peptide cyclization efficiency.Macrocyclic drugs and synthetic methodologies toward macrocyclesBalancing novelty with confined chemical space in modern drug discovery.How proteins bind macrocycles.Diversity-oriented synthesis of drug-like macrocyclic scaffolds using an orthogonal organo- and metal catalysis strategy.A simple protocol for combinatorial cyclic depsipeptide libraries sequencing by matrix-assisted laser desorption/ionisation mass spectrometry.Twisted amide electrophiles enable cyclic peptide sequencing.New Frontiers in DruggabilityHitting a Moving Target: How Does an N-Methyl Group Impact Biological Activity?Modular Synthesis of Novel Macrocycles Bearing α,β-Unsaturated Chemotypes through a Series of One-Pot, Sequential Protocols.Harnessing C-H Activation of Benzhydroxamates as a Macrocyclization Strategy: Synthesis of Structurally Diverse Macrocyclic Isoquinolones.Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase.Extending accessible chemical space for the identification of novel leads.Synthesis and antibacterial evaluation of macrocyclic diarylheptanoid derivativesSynthesis and biological evaluation of palmyrolide A macrocycles as sodium channel blockers towards neuroprotection.On the origins of three-dimensionality in drug-like molecules.Advances in the synthesis of glycosidic macrolides: clavosolides A-D and cyanolide A.Targeting intracellular protein-protein interactions with cell-permeable cyclic peptides.Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates.Linker-free incorporation of carbohydrates into in vitro displayed macrocyclic peptides.Template-induced macrocycle diversity through large ring-forming alkylations of tryptophan.Recent Advances in the Discovery of Norovirus Therapeutics.Beyond cyclosporine A: conformation-dependent passive membrane permeabilities of cyclic peptide natural products.Kinetically E-selective macrocyclic ring-closing metathesisTherapeutic target database update 2014: a resource for targeted therapeutics.New Modalities for Challenging Targets in Drug Discovery.Macrocycles as potential therapeutic agents in neglected diseases.Macrocycles All Aflutter: Substitution at an Allylic Center Reveals Conformational Dynamics of [13]-Macrodilactones.MacroEvoLution: A New Method for the Rapid Generation of Novel Scaffold-Diverse Macrocyclic LibrariesMedicinal applications of (benz)imidazole- and indole-based macrocycles.How Selective are Hsp90 Inhibitors for Cancer Cells over Normal Cells?Synthetic Strategy and Anti-Tumor Activities of Macrocyclic Scaffolds Based on 4-Hydroxyproline.A Palladium-Catalyzed Carbonylation Approach to Eight-Membered Lactam Derivatives with Antitumor Activity.A Blind Test of Computational Technique for Predicting the Likelihood of Peptide Sequences to Cyclize.Functionalized calix[4]arenes as potential therapeutic agents.Structural and conformational determinants of macrocycle cell permeability.The first report of direct inhibitors that target the C-terminal MEEVD region on heat shock protein 90.
P2860
Q26829081-1D4959BF-580A-4DA0-BF62-B34FE0472F42Q27703748-9C100393-FC85-48AA-B6C5-96E8866FC5A7Q30490492-AC2BE391-4BBB-47E1-8C5F-585EE2420261Q34522426-BA2C341A-6A5E-4A1B-A722-15AD7D01DD56Q34740721-EB1B9523-897C-46F9-98A9-91899550FF42Q35071339-B2451CFA-6A97-4B66-B136-F1C613B6F37DQ35209183-87727E74-9DCA-4489-A555-93FD8BE05BD2Q35278303-49E5CA0B-24AB-4ED5-A7C1-8AA97A3B46BEQ35446970-6B6471B9-FB77-4C63-BA23-14C195BE1F3CQ35664642-AF4B5F35-89CE-4B93-8B91-22D022416D64Q35730955-DAD962E8-2FE0-4FAE-AF62-04DAB9CBEA0BQ35902732-F3804A51-B061-463A-BEEC-8E71C5E53159Q35984003-D9B0C42E-C4C8-4C57-A266-BA41A4885601Q36028073-CFE31982-5CFA-4488-83E5-EBECE5DAED52Q36062753-85F2BB82-06E5-4E0B-88F2-04548491A44EQ36068828-92545D5A-239F-4D61-B572-99646F4B39BDQ36074415-34D10040-732A-4DE5-BF07-6D6BC5186FDCQ36106585-E8364549-353F-4445-BA83-135B6FA76775Q36116285-8C75B4CA-F92F-48C7-9556-252F5D98FDCDQ36156057-3552033B-B226-4583-99AC-0BE89E6A17A5Q36339706-443670AF-B31D-44CA-BCD9-28C663A4A9D5Q36372894-C4289271-01C2-4A6B-A854-221C62768AD0Q36390191-2C66AC81-8529-4DF5-9278-C069FE16884CQ37104315-AF3FA3B4-2B52-4006-9CB3-B4D30D76DCD2Q37517465-7BBFCFAE-C12C-440C-8ADC-80A6CE2D4201Q37532708-6732267D-F835-4B49-9E1C-61DCDAE9FA63Q37594878-8D58D101-F622-415D-9E2A-BEF62E085D57Q37661746-A6B8A107-86B2-4B5F-8195-FA88C2897092Q38289100-7195916B-2F44-4170-AE89-98496CD69965Q38343825-46DEEB5E-8881-4A73-90AB-FE6D8FBFB627Q38636770-9E0552F3-FB12-4CC3-BDB1-36BB4AF8362FQ38656515-75F801DC-7179-48F8-A83B-299481943F8BQ38709166-20FA92F3-A3E5-4AA2-A1AD-619439584F18Q38718676-D03290B8-BA1F-432A-9636-D9BE07BC3797Q38793011-8E20EE5E-6E44-4B09-B056-7D86FB0B209CQ38798602-A339E829-457C-4F98-A94E-84E7EC3B9E9DQ38801977-A816B2C8-39E8-466E-8682-114FE0277E45Q39138272-331E37A3-065D-4F30-B8A1-AA426B19D65DQ39283186-14A609C2-566A-4945-B647-30DBCD037EC7Q40362044-651348A5-8F0C-48C5-9D2A-471FA841DD11
P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Macrocycles in new drug discovery.
@en
type
label
Macrocycles in new drug discovery.
@en
prefLabel
Macrocycles in new drug discovery.
@en
P2860
P356
P1476
Macrocycles in new drug discovery.
@en
P2093
Ian Collins
Jamie Mallinson
P2860
P304
P356
10.4155/FMC.12.93
P577
2012-07-01T00:00:00Z