Macrocycles in new drug discovery. - Test2 - elhamkhani - TriplyDB

Macrocycles in new drug discovery.

Macrocycles in new drug discovery.

http://www.wikidata.org/entity/Q38031632

about

Diversity-oriented synthetic strategies applied to cancer chemical biology and drug discovery Oxadiazole-Based Cell Permeable Macrocyclic Transition State Inhibitors of Norovirus 3CL Protease Ring-Expansion Approach to Medium-Sized Lactams and Analysis of Their Medicinal Lead-Like Properties.Global analysis of peptide cyclization efficiency.Macrocyclic drugs and synthetic methodologies toward macrocycles Balancing novelty with confined chemical space in modern drug discovery.How proteins bind macrocycles.Diversity-oriented synthesis of drug-like macrocyclic scaffolds using an orthogonal organo- and metal catalysis strategy.A simple protocol for combinatorial cyclic depsipeptide libraries sequencing by matrix-assisted laser desorption/ionisation mass spectrometry.Twisted amide electrophiles enable cyclic peptide sequencing.New Frontiers in Druggability Hitting a Moving Target: How Does an N-Methyl Group Impact Biological Activity?Modular Synthesis of Novel Macrocycles Bearing α,β-Unsaturated Chemotypes through a Series of One-Pot, Sequential Protocols.Harnessing C-H Activation of Benzhydroxamates as a Macrocyclization Strategy: Synthesis of Structurally Diverse Macrocyclic Isoquinolones.Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase.Extending accessible chemical space for the identification of novel leads.Synthesis and antibacterial evaluation of macrocyclic diarylheptanoid derivatives Synthesis and biological evaluation of palmyrolide A macrocycles as sodium channel blockers towards neuroprotection.On the origins of three-dimensionality in drug-like molecules.Advances in the synthesis of glycosidic macrolides: clavosolides A-D and cyanolide A.Targeting intracellular protein-protein interactions with cell-permeable cyclic peptides.Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates.Linker-free incorporation of carbohydrates into in vitro displayed macrocyclic peptides.Template-induced macrocycle diversity through large ring-forming alkylations of tryptophan.Recent Advances in the Discovery of Norovirus Therapeutics.Beyond cyclosporine A: conformation-dependent passive membrane permeabilities of cyclic peptide natural products.Kinetically E-selective macrocyclic ring-closing metathesis Therapeutic target database update 2014: a resource for targeted therapeutics.New Modalities for Challenging Targets in Drug Discovery.Macrocycles as potential therapeutic agents in neglected diseases.Macrocycles All Aflutter: Substitution at an Allylic Center Reveals Conformational Dynamics of [13]-Macrodilactones.MacroEvoLution: A New Method for the Rapid Generation of Novel Scaffold-Diverse Macrocyclic Libraries Medicinal applications of (benz)imidazole- and indole-based macrocycles.How Selective are Hsp90 Inhibitors for Cancer Cells over Normal Cells?Synthetic Strategy and Anti-Tumor Activities of Macrocyclic Scaffolds Based on 4-Hydroxyproline.A Palladium-Catalyzed Carbonylation Approach to Eight-Membered Lactam Derivatives with Antitumor Activity.A Blind Test of Computational Technique for Predicting the Likelihood of Peptide Sequences to Cyclize.Functionalized calix[4]arenes as potential therapeutic agents.Structural and conformational determinants of macrocycle cell permeability.The first report of direct inhibitors that target the C-terminal MEEVD region on heat shock protein 90.

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Macrocycles in new drug discovery.

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Macrocycles in new drug discovery.

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Macrocycles in new drug discovery.

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Macrocycles in new drug discovery.

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Future Medicinal Chemistry

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Macrocycles in new drug discovery.

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Ian Collins

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Jamie Mallinson

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P2860

Macrocyclic histone deacetylase inhibitors

Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3

2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead

Structure-based design and synthesis of novel macrocyclic pyrazolo[1,5-a] [1,3,5]triazine compounds as potent inhibitors of protein kinase CK2 and their anticancer activities

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1409-1438

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scholarly article

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10.4155/FMC.12.93

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11

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4

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2012-07-01T00:00:00Z

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22857532

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