Abrogation of the Brd4-positive transcription elongation factor B complex by papillomavirus E2 protein contributes to viral oncogene repression
about
Single cell analysis of transcriptional activation dynamicsDesign and characterization of an enhanced repressor of human papillomavirus E2 proteinAnalysis of the papillomavirus E2 and bromodomain protein Brd4 interaction using bimolecular fluorescence complementationCompound A, a selective glucocorticoid receptor modulator, enhances heat shock protein Hsp70 gene promoter activationInduction of p53, p21 and apoptosis by silencing the NF90/NF45 complex in human papilloma virus-transformed cervical carcinoma cells.Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expressionBrd4 engagement from chromatin targeting to transcriptional regulation: selective contact with acetylated histone H3 and H4.The cellular bromodomain protein Brd4 has multiple functions in E2-mediated papillomavirus transcription activationA point mutation in the DNA-binding domain of HPV-2 E2 protein increases its DNA-binding capacity and reverses its transcriptional regulatory activity on the viral early promoter.Human T-lymphotropic virus type 1 Tax protein complexes with P-TEFb and competes for Brd4 and 7SK snRNP/HEXIM1 binding.Mechanistic analysis of the role of bromodomain-containing protein 4 (BRD4) in BRD4-NUT oncoprotein-induced transcriptional activation.Perturbation of BRD4 protein function by BRD4-NUT protein abrogates cellular differentiation in NUT midline carcinomaRAP1 GTPase overexpression is associated with cervical intraepithelial neoplasia.Bromodomain protein Brd4 associated with acetylated chromatin is important for maintenance of higher-order chromatin structure.Papillomavirus-Associated Tumor Formation Critically Depends on c-Fos Expression Induced by Viral Protein E2 and Bromodomain Protein Brd4.A proteomic approach to discover and compare interacting partners of papillomavirus E2 proteins from diverse phylogenetic groupsProteome-scale Binary Interactomics in Human Cells.The Oncogenic Small Tumor Antigen of Merkel Cell Polyomavirus Is an Iron-Sulfur Cluster Protein That Enhances Viral DNA ReplicationCurrent understanding of the role of the Brd4 protein in the papillomavirus lifecycle.Tandemly Integrated HPV16 Can Form a Brd4-Dependent Super-Enhancer-Like Element That Drives Transcription of Viral OncogenesBrd4 Activates Early Viral Transcription upon Human Papillomavirus 18 Infection of Primary Keratinocytes.Brd4-mediated nuclear retention of the papillomavirus E2 protein contributes to its stabilization in host cells.Host DNA damage response factors localize to merkel cell polyomavirus DNA replication sites to support efficient viral DNA replication.Involvement of Brd4 in different steps of the papillomavirus life cycle.Tumor suppressor or oncogene? A critical role of the human papillomavirus (HPV) E2 protein in cervical cancer progression.Epigenetic Alterations in Human Papillomavirus-Associated Cancers.Therapeutics Targeting Protein Acetylation Perturb Latency of Human Viruses.Negative elongation factor-mediated suppression of RNA polymerase II elongation of Kaposi's sarcoma-associated herpesvirus lytic gene expression.Targeting Persistent Human Papillomavirus Infection.Identification of binding sites for myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 in MyD88 adapter-like (Mal).Regulation of the human papillomavirus type 16 late promoter by transcriptional elongation.Identification of interaction sites for dimerization and adapter recruitment in Toll/interleukin-1 receptor (TIR) domain of Toll-like receptor 4.Glucocorticoid Receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor.Interaction of the papillomavirus E8--E2C protein with the cellular CHD6 protein contributes to transcriptional repression.HPV-16 E2 contributes to induction of HPV-16 late gene expression by inhibiting early polyadenylation.Uncovering BRD4 hyperphosphorylation associated with cellular transformation in NUT midline carcinoma.Regulation of the human papillomavirus type 16 late promoter by E7 and the cell cycle.BET bromodomain inhibitors show anti-papillomavirus activity in vitro and block CRPV wart growth in vivo.
P2860
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P2860
Abrogation of the Brd4-positive transcription elongation factor B complex by papillomavirus E2 protein contributes to viral oncogene repression
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
Abrogation of the Brd4-positiv ...... s to viral oncogene repression
@ast
Abrogation of the Brd4-positiv ...... s to viral oncogene repression
@en
Abrogation of the Brd4-positiv ...... to viral oncogene repression.
@nl
type
label
Abrogation of the Brd4-positiv ...... s to viral oncogene repression
@ast
Abrogation of the Brd4-positiv ...... s to viral oncogene repression
@en
Abrogation of the Brd4-positiv ...... to viral oncogene repression.
@nl
prefLabel
Abrogation of the Brd4-positiv ...... s to viral oncogene repression
@ast
Abrogation of the Brd4-positiv ...... s to viral oncogene repression
@en
Abrogation of the Brd4-positiv ...... to viral oncogene repression.
@nl
P2093
P2860
P356
P1433
P1476
Abrogation of the Brd4-positiv ...... s to viral oncogene repression
@en
P2093
Jan Tavernier
Jianxin You
Junpeng Yan
Sam Lievens
P2860
P356
10.1128/JVI.01647-09
P577
2010-01-01T00:00:00Z