The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo
about
Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brainIn Silico and Intuitive Predictions of CYP46A1 Inhibition by Marketed Drugs with Subsequent Enzyme Crystallization in Complex with FluvoxamineBinding of a Cyano- and Fluoro-containing Drug Bicalutamide to Cytochrome P450 46A1: UNUSUAL FEATURES AND SPECTRAL RESPONSEAntifungal Azoles: Structural Insights into Undesired Tight Binding to Cholesterol-Metabolizing CYP46A1Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus's Role in VirulenceThe Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of N-Methyl-D-Aspartate ReceptorsResistance to antifungals that target CYP51.The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme.Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals.On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) miceEndogenous 24S-hydroxycholesterol modulates NMDAR-mediated function in hippocampal slices.Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity24(S)-Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure.Intersection of the Roles of Cytochrome P450 Enzymes with Xenobiotic and Endogenous Substrates: Relevance to Toxicity and Drug Interactions.24(S)-Hydroxycholesterol as a Modulator of Neuronal Signaling and Survival.In vitro cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds.Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1).Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease.
P2860
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P2860
The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The antifungal drug voriconazo ...... droxylase in vitro and in vivo
@ast
The antifungal drug voriconazo ...... droxylase in vitro and in vivo
@en
The antifungal drug voriconazo ...... roxylase in vitro and in vivo.
@nl
type
label
The antifungal drug voriconazo ...... droxylase in vitro and in vivo
@ast
The antifungal drug voriconazo ...... droxylase in vitro and in vivo
@en
The antifungal drug voriconazo ...... roxylase in vitro and in vivo.
@nl
prefLabel
The antifungal drug voriconazo ...... droxylase in vitro and in vivo
@ast
The antifungal drug voriconazo ...... droxylase in vitro and in vivo
@en
The antifungal drug voriconazo ...... roxylase in vitro and in vivo.
@nl
P2093
P2860
P50
P1476
The antifungal drug voriconazo ...... droxylase in vitro and in vivo
@en
P2093
Dieter Lütjohann
Gun Young Heo
Linda Björkhem-Bergman
Marjan Shafaati
Natalia Mast
Rima Nayef
P2860
P304
P356
10.1194/JLR.M900174-JLR200
P577
2009-05-27T00:00:00Z