Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain
about
Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer diseaseCrystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug designSenile plaque neurites in Alzheimer disease accumulate amyloid precursor proteinCrystal structure of human pepsin and its complex with pepstatinDiabetes Mellitus Induces Alzheimer's Disease Pathology: Histopathological Evidence from Animal ModelsCathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug CandidateLysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivoThe cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activityCathepsin D--many functions of one aspartic proteaseCysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's diseasePresenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membraneThe autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice.Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity.Extracellular Vesicle-Associated Aβ Mediates Trans-Neuronal Bioenergetic and Ca2+-Handling Deficits in Alzheimer's Disease Models.Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach.The human amyloid-beta precursor protein770 mutation V717F generates peptides longer than amyloid-beta-(40-42) and flocculent amyloid aggregates.Human cathepsin X: a novel cysteine protease of the papain family with a very short proregion and unique insertions.Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease.Microglial secreted cathepsin B induces neuronal apoptosis.Comparative proteomics of cerebrospinal fluid in neuropathologically-confirmed Alzheimer's disease and non-demented elderly subjects.Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer's disease-linked presenilin 1 A246E mutation can be reversed with cAMPCathepsin D regulates lipid metabolism in murine steatohepatitis.Preclinical Alzheimer disease: brain oxidative stress, Abeta peptide and proteomics.Oxidative stress and autophagy in the regulation of lysosome-dependent neuron death.Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Neuroprotective role of γ-enolase in microglia in a mouse model of Alzheimer's disease is regulated by cathepsin X.The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus.Integrated approaches for analyzing U1-70K cleavage in Alzheimer's disease.Protective mechanisms by cystatin C in neurodegenerative diseases.Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagySubcellular topography of neuronal Abeta peptide in APPxPS1 transgenic mice.Normal processing of the Alzheimer's disease amyloid beta protein precursor generates potentially amyloidogenic carboxyl-terminal derivatives.Regulation of neuronal cells and astrocytes by protease nexin-1 and thrombin.Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathologyRelaxin enhances the oncogenic potential of human thyroid carcinoma cells.Accumulation of amyloid-like Aβ1-42 in AEL (autophagy-endosomal-lysosomal) vesicles: potential implications for plaque biogenesis.Alzheimer's disease neuropathology. Current status of interpretation of lesion development.Calcium channel blocking as a therapeutic strategy for Alzheimer's disease: the case for isradipine.Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain
P2860
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P2860
Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain
description
1990 nî lūn-bûn
@nan
1990 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Enzymatically active lysosomal ...... id deposits in Alzheimer brain
@ast
Enzymatically active lysosomal ...... id deposits in Alzheimer brain
@en
type
label
Enzymatically active lysosomal ...... id deposits in Alzheimer brain
@ast
Enzymatically active lysosomal ...... id deposits in Alzheimer brain
@en
prefLabel
Enzymatically active lysosomal ...... id deposits in Alzheimer brain
@ast
Enzymatically active lysosomal ...... id deposits in Alzheimer brain
@en
P2860
P356
P1476
Enzymatically active lysosomal ...... id deposits in Alzheimer brain
@en
P2093
A M Cataldo
P2860
P304
P356
10.1073/PNAS.87.10.3861
P407
P577
1990-05-01T00:00:00Z