Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors. - Test2 - elhamkhani - TriplyDB

Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors.

Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors.

http://www.wikidata.org/entity/Q33613391

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The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIα PLEKHG2 promotes heterotrimeric G protein βγ-stimulated lymphocyte migration via Rac and Cdc42 activation and actin polymerization.Phosphoinositides: tiny lipids with giant impact on cell regulation Heterotrimeric G-protein Signaling Is Critical to Pathogenic Processes in Entamoeba histolytica Structural Determinants of RGS-RhoGEF Signaling Critical to Entamoeba histolytica Pathogenesis The phospholipase C isozymes and their regulation Functional cross-talk between ras and rho pathways: a Ras-specific GTPase-activating protein (p120RasGAP) competitively inhibits the RhoGAP activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine finger Phospholipase C epsilon scaffolds to muscle-specific A kinase anchoring protein (mAKAPbeta) and integrates multiple hypertrophic stimuli in cardiac myocytes p63RhoGEF couples Gα(q/11)-mediated signaling to Ca2+ sensitization of vascular smooth muscle contractility.Kinetics of recruitment and allosteric activation of ARHGEF25 isoforms by the heterotrimeric G-protein Gαq Stimulation of α1a adrenergic receptors induces cellular proliferation or antiproliferative hypertrophy dependent solely on agonist concentration STIM1 controls endothelial barrier function independently of Orai1 and Ca2+ entry.Galpha q allosterically activates and relieves autoinhibition of p63RhoGEF.Modification of p115RhoGEF Ser(330) regulates its RhoGEF activity.Nerve-released acetylcholine contracts urinary bladder smooth muscle by inducing action potentials independently of IP3-mediated calcium release.G protein signaling in the parasite Entamoeba histolytica Modulation of a GEF switch: autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF Intramolecular interactions between the Dbl homology (DH) domain and the carboxyl-terminal region of myosin II-interacting guanine nucleotide exchange factor (MyoGEF) act as an autoinhibitory mechanism for the regulation of MyoGEF functions.Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets.Activation of Gq/11 in the mouse corpus luteum is required for parturition.Plasma membrane association of p63 Rho guanine nucleotide exchange factor (p63RhoGEF) is mediated by palmitoylation and is required for basal activity in cells Rho kinase as a therapeutic target in cardiovascular disease.RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock.Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13 Gastrin-stimulated Gα13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells.OX1 orexin/hypocretin receptor activation of phospholipase D.Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domain Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer.The α-subunit of the trimeric GTPase Go2 regulates axonal growth Activated RhoA is a positive feedback regulator of the Lbc family of Rho guanine nucleotide exchange factor proteins.PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation PDZ-RhoGEF is essential for CXCR4-driven breast tumor cell motility through spatial regulation of RhoA.Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil.Revisited and revised: is RhoA always a villain in cardiac pathophysiology?Protein-protein interactions: a mechanism regulating the anti-metastatic properties of Nm23-H1.Inhibition and termination of physiological responses by GTPase activating proteins.Ras and Rho small G proteins: insights from the Schizophyllum commune genome sequence and comparisons to other fungi.Lysophospholipid receptor activation of RhoA and lipid signaling pathways.Signal transduction pathways in chronic inflammatory autoimmune disease: small GTPases.Dynamics of Gαq-protein-p63RhoGEF interaction and its regulation by RGS2.

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P2860

Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors.

http://www.wikidata.org/entity/Q33613391

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2009 nî lūn-bûn

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2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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name

Structure and function of hete ...... e nucleotide exchange factors.

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Structure and function of hete ...... e nucleotide exchange factors.

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Structure and function of hete ...... e nucleotide exchange factors.

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Structure and function of hete ...... e nucleotide exchange factors.

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Structure and function of hete ...... e nucleotide exchange factors.

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Structure and function of hete ...... e nucleotide exchange factors.

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Molecular Pharmacology

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Structure and function of hete ...... e nucleotide exchange factors.

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Cassandra A Boguth

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John J G Tesmer

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Mohamed Aittaleb

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P2860

Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains

A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs)

P-Rex2, a new guanine-nucleotide exchange factor for Rac

Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins

The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle

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10.1124/MOL.109.061234

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19880753

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protein structure

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