P-Rex2, a new guanine-nucleotide exchange factor for Rac
about
Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2aRho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and diseaseInositol polyphosphate 5-phosphatases; new players in the regulation of cilia and ciliopathiesRegulation and function of P-Rex family Rac-GEFsP-Rex2 regulates Purkinje cell dendrite morphology and motor coordination.Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasisPhosphorylation of P-Rex1 by the cyclic AMP-dependent protein kinase inhibits the phosphatidylinositiol (3,4,5)-trisphosphate and Gbetagamma-mediated regulation of its activity.Differential sensitivity of P-Rex1 to isoforms of G protein betagamma dimers.Vav3-deficient mice exhibit a transient delay in cerebellar developmentSubstrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2.Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors.Regulated localization is sufficient for hormonal control of regulator of G protein signaling homology Rho guanine nucleotide exchange factors (RH-RhoGEFs).Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits.Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase.Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42.Lack of a significant role of P-Rex1, a major regulator of macrophage Rac1 activation and chemotaxis, in atherogenesisIdentification of P-Rex1 as a novel Rac1-guanine nucleotide exchange factor (GEF) that promotes actin remodeling and GLUT4 protein trafficking in adipocytesIdentification of components of the host type IA phosphoinositide 3-kinase pathway that promote internalization of Listeria monocytogenes.Rac signaling in breast cancer: a tale of GEFs and GAPs.The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase.Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanomaStructural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion.Signaling via class IA Phosphoinositide 3-kinases (PI3K) in human, breast-derived cell linesDifferential inhibitor of Gbetagamma signaling to AKT and ERK derived from phosducin-like protein: effect on sphingosine 1-phosphate-induced endothelial cell migration and in vitro angiogenesisNeuronal Rho GEFs in synaptic physiology and behavior.Analysis of intracellular PTEN signaling and secretion.Upregulation of PREX2 promotes the proliferation and migration of hepatocellular carcinoma cells via PTEN-AKT signaling.Regulation of NADPH oxidases in skeletal muscle.Molecular Pathways: Targeting the PI3K Pathway in Cancer-BET Inhibitors to the RescueGβγ Pathways in Cell Polarity and Migration Linked to Oncogenic GPCR Signaling: Potential Relevance in Tumor Microenvironment.The effect of CXCL9 on the invasion ability of hepatocellular carcinoma through up-regulation of PREX2.PREX1 Protein Function Is Negatively Regulated Downstream of Receptor Tyrosine Kinase Activation by p21-activated Kinases (PAKs).Interplay between PREX2 mutations and the PI3K pathway and its effect on epigenetic regulation of gene expression in NRAS-mutant melanomaCharacterization of the GNMT-HectH9-PREX2 tripartite relationship in the pathogenesis of hepatocellular carcinoma.Mechanistic insights into the role of truncating PREX2 mutations in melanoma.Multisite phosphorylation of P-Rex1 by protein kinase C.The guanine-nucleotide-exchange factor P-Rex1 is activated by protein phosphatase 1α.The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN.
P2860
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P2860
P-Rex2, a new guanine-nucleotide exchange factor for Rac
description
2004 nî lūn-bûn
@nan
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
P-Rex2, a new guanine-nucleotide exchange factor for Rac
@ast
P-Rex2, a new guanine-nucleotide exchange factor for Rac
@en
P-Rex2, a new guanine-nucleotide exchange factor for Rac
@en-gb
P-Rex2, a new guanine-nucleotide exchange factor for Rac
@nl
type
label
P-Rex2, a new guanine-nucleotide exchange factor for Rac
@ast
P-Rex2, a new guanine-nucleotide exchange factor for Rac
@en
P-Rex2, a new guanine-nucleotide exchange factor for Rac
@en-gb
P-Rex2, a new guanine-nucleotide exchange factor for Rac
@nl
prefLabel
P-Rex2, a new guanine-nucleotide exchange factor for Rac
@ast
P-Rex2, a new guanine-nucleotide exchange factor for Rac
@en
P-Rex2, a new guanine-nucleotide exchange factor for Rac
@en-gb
P-Rex2, a new guanine-nucleotide exchange factor for Rac
@nl
P2093
P2860
P50
P1433
P1476
P-Rex2, a new guanine-nucleotide exchange factor for Rac
@en
P2093
Charlotte Lecureuil
Kirsti Hill
Romain Barnouin
Sarah Donald
Simon A Walker
Simon R Andrews
W John Coadwell
P2860
P356
10.1016/J.FEBSLET.2004.06.096
P407
P577
2004-08-13T00:00:00Z