Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin.
about
Regulation of TOR by small GTPasesNutrient-sensing mechanisms across evolutionTORC1 promotes phosphorylation of ribosomal protein S6 via the AGC kinase Ypk3 in Saccharomyces cerevisiaeNon-canonical functions of the tuberous sclerosis complex-Rheb signalling axisFission yeast arrestin-related trafficking adaptor, Arn1/Any1, is ubiquitinated by Pub1 E3 ligase and regulates endocytosis of Cat1 amino acid transporter.Rab-family GTPase regulates TOR complex 2 signaling in fission yeastDeletion of the fission yeast homologue of human insulinase reveals a TORC1-dependent pathway mediating resistance to proteotoxic stress.Activating mutations of TOR (target of rapamycin).Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.Chemical genomics approach to identify genes associated with sensitivity to rapamycin in the fission yeast Schizosaccharomyces pombe.Rhb1 regulates the expression of secreted aspartic protease 2 through the TOR signaling pathway in Candida albicans.Tor Signaling Regulates Transcription of Amino Acid Permeases through a GATA Transcription Factor Gaf1 in Fission YeastThe Loss of Lam2 and Npr2-Npr3 Diminishes the Vacuolar Localization of Gtr1-Gtr2 and Disinhibits TORC1 Activity in Fission YeastFission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucosePsk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 and functions as S6 kinaseCharacterization of genome-reduced fission yeast strainsLack of tRNA modification isopentenyl-A37 alters mRNA decoding and causes metabolic deficiencies in fission yeast.TORC1 signaling is governed by two negative regulators in fission yeast.Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition.The Aspergillus fumigatus SchASCH9 kinase modulates SakAHOG1 MAP kinase activity and it is essential for virulence.Torin1-mediated TOR kinase inhibition reduces Wee1 levels and advances mitotic commitment in fission yeast and HeLa cellsTOR links starvation responses to telomere length maintenance.Crosstalk between the Tor and Gcn2 pathways in response to different stressesGenetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.TORC1-Dependent Phosphorylation Targets in Fission YeastTORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast.Isp7 is a novel regulator of amino acid uptake in the TOR signaling pathway.Phosphorylation of the amino-terminus of the AGC kinase Gad8 prevents its interaction with TORC2.The Vam6 and Gtr1-Gtr2 pathway activates TORC1 in response to amino acids in fission yeastConstitutive Tor2 Activity Promotes Retention of the Amino Acid Transporter Agp3 at Trans-Golgi/Endosomes in Fission Yeast.Ribosomal protein S6 phosphorylation is controlled by TOR and modulated by PKA in Candida albicans.Gad8 Protein Is Found in the Nucleus Where It Interacts with the MluI Cell Cycle Box-binding Factor (MBF) Transcriptional Complex to Regulate the Response to DNA Replication Stress.TORC1 Regulates Developmental Responses to Nitrogen Stress via Regulation of the GATA Transcription Factor Gaf1.The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe.A central role for TOR signalling in a yeast model for juvenile CLN3 diseaseMultiple crosstalk between TOR and the cell integrity MAPK signaling pathway in fission yeast.TORC2 is required to maintain genome stability during S phase in fission yeast.TORC2 and the AGC kinase Gad8 regulate phosphorylation of the ribosomal protein S6 in fission yeastDifferent evolutionary modifications as a guide to rewire two-component systems.Recovery from rapamycin: drug-insensitive activity of yeast target of rapamycin complex 1 (TORC1) supports residual proliferation that dilutes rapamycin among progeny cells.
P2860
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P2860
Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin.
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Fission yeast TORC1 regulates ...... ity is inhibited by rapamycin.
@ast
Fission yeast TORC1 regulates ...... ity is inhibited by rapamycin.
@en
type
label
Fission yeast TORC1 regulates ...... ity is inhibited by rapamycin.
@ast
Fission yeast TORC1 regulates ...... ity is inhibited by rapamycin.
@en
prefLabel
Fission yeast TORC1 regulates ...... ity is inhibited by rapamycin.
@ast
Fission yeast TORC1 regulates ...... ity is inhibited by rapamycin.
@en
P2093
P2860
P356
P1476
Fission yeast TORC1 regulates ...... ity is inhibited by rapamycin.
@en
P2093
Akio Nakashima
Fuyuhiko Tamanoi
Tatsuhiro Sato
P2860
P304
P356
10.1242/JCS.060319
P407
P577
2010-02-09T00:00:00Z