mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
about
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2Understanding the impact of 1q21.1 copy number variantA Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexesRagulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1Germline mutations in TMEM127 confer susceptibility to pheochromocytomaStructural analysis and functional implications of the negative mTORC1 regulator REDD1Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycinmTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4EIdentification of Protor as a novel Rictor-binding component of mTOR complex-2Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitiveThe insulin-like growth factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growthThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complexmTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signalingPRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins.Signaling by target of rapamycin proteins in cell growth controlNutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylationThe C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylationAmino acids as regulators of gene expressionDisruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell developmentmTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cellsNaturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanismUpdates of mTOR inhibitorsResveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTORRole of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacksSpatial regulation of the mTORC1 system in amino acids sensing pathwayOsmotic stress regulates mammalian target of rapamycin (mTOR) complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor protein phosphorylationThe mTOR signalling pathway in human cancerThe tuberous sclerosis complexNext-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategyAn emerging role for TOR signaling in mammalian tissue and stem cell physiologyMammalian target of rapamycin (mTOR): conducting the cellular signaling symphonyAkt and autophagy cooperate to promote survival of drug-resistant gliomaFoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and RictorTargeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapyRictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cellsTti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly
P2860
Q21145847-3E40CC9A-B193-42F5-A968-3A418B776D7BQ21202865-75A828E5-6F58-43E5-B003-E63948D87CE8Q24294219-C7A0B4B8-3969-4096-9FA8-D4C62C19F620Q24297874-67E47F38-0CA1-4704-97E6-F28216D31EB3Q24298767-C2562D0E-E1E0-48AE-84C0-6A02FE5792CFQ24299202-D865F642-7D3B-4E63-85D5-C925661AA21CQ24300025-96976C3D-D632-4C97-A49B-68B3FC92A9B1Q24301667-68C88474-3C33-4DE4-9CAB-4169F6397855Q24301780-44E8F272-F9F5-439A-ADF7-931BC7C3E86AQ24303936-FB64E801-A8BC-4703-BC26-815AF5567173Q24306328-08045E6A-CB43-4F01-B93D-3C43FD172F18Q24314865-4A8675B2-204A-4AEF-A95C-F91BEC242354Q24315566-912A2314-790A-490C-B9AE-3216859FD33AQ24316314-92579FC8-6046-4E97-A2BC-CA5D1FA57898Q24319851-BA5D1BF5-1097-44BD-A72D-A1006D0B7948Q24320106-342BAD65-04D2-405F-8EFB-FFF90AFF7B61Q24323912-852F999A-4259-4E84-97CD-93950787DB83Q24519078-16655F05-2BE8-4F9E-B596-ADF55300D1D1Q24522447-6DE80695-840A-4530-96BB-A944623C95FCQ24535576-0E61782B-2E33-4C9D-B571-4971B17C69AAQ24554323-36FEE966-5526-4F16-96B8-EB42B88B03E7Q24562847-2E0E2BC0-4EF7-41DC-9663-21129A7F321BQ24563399-B24AA94B-F42D-4420-A830-F796363244E7Q24564276-2A1E4CFF-E878-4D00-AF09-496B05115AA0Q24595310-CC783133-6366-40A6-B185-EE36095A122CQ24607170-65B1F3C4-EEDD-42D9-90F4-7A7AF4741197Q24608321-65BEC36A-84D9-4490-B3D4-611E159EBA5AQ24612235-6F8AE329-226B-4B68-BB57-95CD30C49F86Q24612853-BEE465B1-BA98-469E-86A5-C489B4368308Q24614093-A359B9D8-08B6-4A96-9538-F66BB671C04CQ24627306-94403B8C-2DB6-4B8B-8152-751274D49D03Q24628011-FE179679-221B-41DD-A686-56D87AE75008Q24628724-2AF63585-E57E-4CA1-9258-9A00E02A2B12Q24629305-602BDA92-CCB7-41AA-A4D9-E7B3F408928DQ24629514-2CAE0D62-A4CE-438D-9051-3329B4A740F1Q24629677-BC5C9202-4016-4F65-BA79-C5DACA61E093Q24632191-6500A857-61F6-44E9-838F-5EB80F66D4FEQ24632296-E33D3A1A-74AE-4F6E-AAE9-F1054951A8CAQ24632684-DEAB31EC-3DE5-45EA-B48A-FBD0C388D3EFQ24632884-493AFB18-D190-4E79-A187-7397E9E2930C
P2860
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
description
2002 nî lūn-bûn
@nan
2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
name
mTOR interacts with raptor to ...... s to the cell growth machinery
@ast
mTOR interacts with raptor to ...... s to the cell growth machinery
@en
mTOR interacts with raptor to ...... s to the cell growth machinery
@en-gb
mTOR interacts with raptor to ...... s to the cell growth machinery
@nl
type
label
mTOR interacts with raptor to ...... s to the cell growth machinery
@ast
mTOR interacts with raptor to ...... s to the cell growth machinery
@en
mTOR interacts with raptor to ...... s to the cell growth machinery
@en-gb
mTOR interacts with raptor to ...... s to the cell growth machinery
@nl
prefLabel
mTOR interacts with raptor to ...... s to the cell growth machinery
@ast
mTOR interacts with raptor to ...... s to the cell growth machinery
@en
mTOR interacts with raptor to ...... s to the cell growth machinery
@en-gb
mTOR interacts with raptor to ...... s to the cell growth machinery
@nl
P2093
P50
P3181
P1433
P1476
mTOR interacts with raptor to ...... s to the cell growth machinery
@en
P2093
D D Sarbassov
David M Sabatini
Jessie E King
Robert R Latek
Siraj M Ali
P304
P3181
P356
10.1016/S0092-8674(02)00808-5
P407
P577
2002-07-26T00:00:00Z