Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter
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Characterization of the commercially-available fluorescent chloroquine-BODIPY conjugate, LynxTag-CQGREEN, as a marker for chloroquine resistance and uptake in a 96-well plate assayImplications of Glutathione Levels in the Plasmodium berghei Response to Chloroquine and ArtemisininMolecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance TransporterEvolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole PhysiologyMultiple drugs compete for transport via the Plasmodium falciparum chloroquine resistance transporter at distinct but interdependent sitesHigh-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinationsCharacterization of the chloroquine resistance transporter homologue in Toxoplasma gondiiA Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug PiperaquineTemporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter.Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities.Combinatorial Genetic Modeling of pfcrt-Mediated Drug Resistance Evolution in Plasmodium falciparum.Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies.Functional Comparison of 45 Naturally Occurring Isoforms of the Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT).H2B ubiquitination regulates meiotic recombination by promoting chromatin relaxationReemergence of chloroquine-sensitive pfcrt K76 Plasmodium falciparum genotype in southeastern CameroonIron is a substrate of the Plasmodium falciparum chloroquine resistance transporter PfCRT in Xenopus oocytes.Unexpected selections of Plasmodium falciparum polymorphisms in previously treatment-naïve areas after monthly presumptive administration of three different anti-malarial drugs in Liberia 1976-78.Return of chloroquine sensitivity to Africa? Surveillance of African Plasmodium falciparum chloroquine resistance through malaria imported to China.Plasmodium falciparum chloroquine resistance transporter (PfCRT) isoforms PH1 and PH2 perturb vacuolar physiology.High-Dose Chloroquine for Treatment of Chloroquine-Resistant Plasmodium falciparum Malaria.Genetic mutations in pfcrt and pfmdr1 at the time of artemisinin combination therapy introduction in South Pacific islands of Vanuatu and Solomon Islands.Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via the Plasmodium falciparum Chloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs.A systematic and prospectively validated approach for identifying synergistic drug combinations against malaria.Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter
P2860
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P2860
Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter
description
2014 nî lūn-bûn
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2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Diverse mutational pathways co ...... roquine resistance transporter
@ast
Diverse mutational pathways co ...... roquine resistance transporter
@en
type
label
Diverse mutational pathways co ...... roquine resistance transporter
@ast
Diverse mutational pathways co ...... roquine resistance transporter
@en
prefLabel
Diverse mutational pathways co ...... roquine resistance transporter
@ast
Diverse mutational pathways co ...... roquine resistance transporter
@en
P2093
P2860
P50
P921
P356
P1476
Diverse mutational pathways co ...... roquine resistance transporter
@en
P2093
Anurag Dave
Cecilia P Sanchez
Megan N Nash
Robyn L Schenk
Rosa V Marchetti
Sashika N Richards
Sebastiano Bellanca
Tegan J Dolstra
Valerie Goh
Wilfred D Stein
P2860
P304
P356
10.1073/PNAS.1322965111
P407
P577
2014-04-11T00:00:00Z