The impact of population demography and selection on the genetic architecture of complex traits.
about
Explosive genetic evidence for explosive human population growthUnderstanding rare and common diseases in the context of human evolutionTrans-ethnic genome-wide association studies: advantages and challenges of mapping in diverse populations.A Meta-Assembly of Selection Signatures in CattleGenetics of Type 2 Diabetes: the Power of Isolated Populations.Efficient inference of population size histories and locus-specific mutation rates from large-sample genomic variation data.Inference of the Distribution of Selection Coefficients for New Nonsynonymous Mutations Using Large Samples.Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs.Population genetic simulations of complex phenotypes with implications for rare variant association testsGenetic simulation tools for post-genome wide association studies of complex diseasesNo evidence that selection has been less effective at removing deleterious mutations in Europeans than in AfricansThe genetic architecture of gene expression levels in wild baboons.Dominance of Deleterious Alleles Controls the Response to a Population BottleneckEfficient Coalescent Simulation and Genealogical Analysis for Large Sample Sizes.A Model of Compound Heterozygous, Loss-of-Function Alleles Is Broadly Consistent with Observations from Complex-Disease GWAS Datasets.MixFit: Methodology for Computing Ancestry-Related Genetic Scores at the Individual Level and Its Application to the Estonian and Finnish Population Studies.Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysisDistance from sub-Saharan Africa predicts mutational load in diverse human genomes.Selection and explosive growth alter genetic architecture and hamper the detection of causal rare variants.Estimating the mutation load in human genomesThe pattern and distribution of deleterious mutations in maize.Whole-genome sequencing of six Mauritian Cynomolgus macaques (Macaca fascicularis) reveals a genome-wide pattern of polymorphisms under extreme population bottleneck.A Temporal Perspective on the Interplay of Demography and Selection on Deleterious Variation in Humans.Exact Calculation of the Joint Allele Frequency Spectrum for Isolation with Migration Models.Genetics of Lipid and Lipoprotein Disorders and Traits.What can genome-wide association studies tell us about the evolutionary forces maintaining genetic variation for quantitative traits?Association mapping of morphological traits in wild and captive zebra finches: reliable within, but not between populations.Recent demography drives changes in linked selection across the maize genome.Evidence of selection as a cause for racial disparities in fibroproliferative disease.The Nature of Genetic Variation for Complex Traits Revealed by GWAS and Regional Heritability Mapping Analyses.Characteristics of neutral and deleterious protein-coding variation among individuals and populations.Incomplete dominance of deleterious alleles contributes substantially to trait variation and heterosis in maize.Complex trait architecture: the pleiotropic model revisited.Evidence of directional and stabilizing selection in contemporary humans.Genetic costs of domestication and improvement.Modeling the Multiple Facets of Speciation-with-Gene-Flow toward Inferring the Divergence History of Lake Whitefish Species Pairs (Coregonus clupeaformis).The Effect of an Extreme and Prolonged Population Bottleneck on Patterns of Deleterious Variation: Insights from the Greenlandic Inuit.A population genetic interpretation of GWAS findings for human quantitative traits.Relationship between Deleterious Variation, Genomic Autozygosity, and Disease Risk: Insights from The 1000 Genomes Project.Population genetics and GWAS: A primer.
P2860
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P2860
The impact of population demography and selection on the genetic architecture of complex traits.
description
2014 nî lūn-bûn
@nan
2014 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
The impact of population demog ...... rchitecture of complex traits.
@ast
The impact of population demog ...... rchitecture of complex traits.
@en
type
label
The impact of population demog ...... rchitecture of complex traits.
@ast
The impact of population demog ...... rchitecture of complex traits.
@en
prefLabel
The impact of population demog ...... rchitecture of complex traits.
@ast
The impact of population demog ...... rchitecture of complex traits.
@en
P2860
P1433
P1476
The impact of population demog ...... rchitecture of complex traits.
@en
P2093
Kirk E Lohmueller
P2860
P304
P356
10.1371/JOURNAL.PGEN.1004379
P577
2014-05-29T00:00:00Z