Characteristics of neutral and deleterious protein-coding variation among individuals and populations.
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Human Knockout Carriers: Dead, Diseased, Healthy, or Improved?Explosive genetic evidence for explosive human population growthUnderstanding rare and common diseases in the context of human evolutionGenetics of Type 2 Diabetes: the Power of Isolated Populations.A flexible method for estimating the fraction of fitness influencing mutations from large sequencing data sets.Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs.Global diversity, population stratification, and selection of human copy-number variation.Estimating the selective effects of heterozygous protein-truncating variants from human exome data.Functional and Structural Consequence of Rare Exonic Single Nucleotide Polymorphisms: One Story, Two Tales.Patterns of deleterious variation between human populations reveal an unbalanced load.Distance from sub-Saharan Africa predicts mutational load in diverse human genomes.Estimating the mutation load in human genomesChallenges and disparities in the application of personalized genomic medicine to populations with African ancestry.A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome.A Temporal Perspective on the Interplay of Demography and Selection on Deleterious Variation in Humans.Living in an adaptive world: Genomic dissection of the genus Homo and its immune response.Family-Specific Variants and the Limits of Human Genetics.The impact of recent population history on the deleterious mutation load in humans and close evolutionary relatives.Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study.Human RECQ Helicase Pathogenic Variants, Population Variation and "Missing" Diseases.Recombination Rate Variation, Hitchhiking, and Demographic History Shape Deleterious Load in Poplar.When Is Selection Effective?Selective Strolls: Fixation and Extinction in Diploids Are Slower for Weakly Selected Mutations Than for Neutral OnesHuman Demographic History Impacts Genetic Risk Prediction across Diverse Populations.Accumulation of Deleterious Mutations During Bacterial Range Expansions.MtDNA genomes reveal a relaxation of selective constraints in low-BMI individuals in a Uyghur population.Improving performance of multigene panels for genomic analysis of cancer predisposition.The interplay of demography and selection during maize domestication and expansion.Slightly deleterious genomic variants and transcriptome perturbations in Down syndrome embryonic selection.The Effect of an Extreme and Prolonged Population Bottleneck on Patterns of Deleterious Variation: Insights from the Greenlandic Inuit.Human genetics: Dissecting deleterious mutation complexity.Expansion load: recessive mutations and the role of standing genetic variation.Patterns of variation in cis-regulatory regions: examining evidence of purifying selection.Elevated Proportions of Deleterious Genetic Variation in Domestic Animals and Plants.Novel Genetic, Clinical, and Pathomechanistic Insights into TFG-Associated Hereditary Spastic Paraplegia.Fine Time Scaling of Purifying Selection on Human Nonsynonymous mtDNA Mutations Based on the Worldwide Population Tree and Mother-Child Pairs.Understanding the Hidden Complexity of Latin American Population Isolates
P2860
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P2860
Characteristics of neutral and deleterious protein-coding variation among individuals and populations.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Characteristics of neutral and ...... g individuals and populations.
@en
type
label
Characteristics of neutral and ...... g individuals and populations.
@en
prefLabel
Characteristics of neutral and ...... g individuals and populations.
@en
P2093
P2860
P1476
Characteristics of neutral and ...... g individuals and populations.
@en
P2093
Joshua M Akey
Michael J Bamshad
Rachel M Gittelman
Wenqing Fu
P2860
P304
P356
10.1016/J.AJHG.2014.09.006
P407
P577
2014-10-01T00:00:00Z