Brk/PTK6 signaling in normal and cancer cell models. - Test2 - elhamkhani - TriplyDB

Brk/PTK6 signaling in normal and cancer cell models.

Brk/PTK6 signaling in normal and cancer cell models.

http://www.wikidata.org/entity/Q33690176

about

SAM68: Signal Transduction and RNA Metabolism in Human Cancer Probabilistic models of genetic variation in structured populations applied to global human studies The alternative splice variant of protein tyrosine kinase 6 negatively regulates growth and enhances PTK6-mediated inhibition of β-catenin MUFFINN: cancer gene discovery via network analysis of somatic mutation data.The associated pyrazolopyrimidines PP1 and PP2 inhibit protein tyrosine kinase 6 activity and suppress breast cancer cell proliferation.HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion.Mechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progression.PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors.Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK.PTK6 inhibition promotes apoptosis of Lapatinib-resistant Her2(+) breast cancer cells by inducing Bim.Overexpression of Kinesin Associated Protein 3 (KIFAP3) in Breast Cancer Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer Protein tyrosine kinase 6 is associated with nasopharyngeal carcinoma poor prognosis and metastasis.Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells.Protein tyrosine kinase 6 regulates mammary gland tumorigenesis in mouse models.Context-specific protein tyrosine kinase 6 (PTK6) signalling in prostate cancer.Non-receptor protein tyrosine kinases signaling pathways in normal and cancer cells.RSK promotes prostate cancer progression in bone through ING3, CKAP2, and PTK6-mediated cell survival PTK6 activation at the membrane regulates epithelial-mesenchymal transition in prostate cancer.Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells.Disruption of the mouse protein tyrosine kinase 6 gene prevents STAT3 activation and confers resistance to azoxymethane.Targeting protein tyrosine kinase 6 enhances apoptosis of colon cancer cells following DNA damage.Downregulated expression of PTK6 is correlated with poor survival in esophageal squamous cell carcinoma.PTK6 Localized at the Plasma Membrane Promotes Cell Proliferation and MigratiOn Through Phosphorylation of Eps8.Global Signaling Profiling in a Human Model of Tumorigenic Progression Indicates a Role for Alternative RNA Splicing in Cellular Reprogramming

P2860

Q26798149-30D9E952-2316-4E06-9E12-DFC6061A6CF7 Q28389960-C262F13E-CA95-479D-902A-5FA8D75C3730 Q30155592-50BCCA07-021E-40DF-864E-975E0807720E Q31110093-677AB3F7-34FD-498A-A098-1679EE0D62FD Q33598866-DA7D834B-9A28-44A5-988E-0BE6D4FE3E7C Q34036107-6EB0C000-7D19-466F-95C8-B6E1E37E59A7 Q34085432-CC5C2E5E-1EBA-48CF-B417-4A1E7394D810 Q34227580-EC3CC124-8F61-4E14-8AAB-92042F062F55 Q34912116-E774BE66-EBE7-439D-BB98-EF99B86842BC Q35683544-B28EE55F-DE50-42C5-9366-AD394F8A6262 Q35834635-0DEF86CB-D7DC-4BBD-BF3D-D07BE9CD371D Q36525056-805B04AC-3546-4FE3-8269-BCBDD42F38E1 Q36693131-DBE251AF-B20F-45F9-996B-D86A13E47D4D Q36940726-CF445BF7-D089-45E2-8F3D-E11921B4D6BB Q37112768-87C4CE2B-65E0-453C-9BC5-FFB68FBBD997 Q37614521-40E5CD89-ABFF-4480-8D2D-0E54AD054470 Q38080556-1E10A1AE-E8AC-4FCB-A682-042E189F19BD Q38180461-957A9886-5E66-490C-B5C3-7E7CA9A7331D Q38959778-C26DBEB5-D38F-449A-A42F-D940B3662A54 Q39125642-64561418-08EF-40CC-945E-82820D241301 Q39304863-17B8BE59-F2A1-4BA7-8523-88598B25D789 Q39509825-1743C0C3-A7DA-4FF2-B4A5-F1B772049DBC Q42357549-3FDBB660-459A-48DE-8DC3-C2839467CCDE Q44349158-3DD8399B-D4EF-4EC5-9935-B2B846F6C41A Q48220908-FE9D2A91-183E-4B78-AB3C-D594EEEAA3EB Q59138288-BA34D71D-3375-4576-8828-15A2B1EFA1A8

P2860

Brk/PTK6 signaling in normal and cancer cell models.

http://www.wikidata.org/entity/Q33690176

description

2010 nî lūn-bûn

@nan

2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Brk/PTK6 signaling in normal and cancer cell models.

@ast

Brk/PTK6 signaling in normal and cancer cell models.

@en

type

label

Brk/PTK6 signaling in normal and cancer cell models.

@ast

Brk/PTK6 signaling in normal and cancer cell models.

@en

prefLabel

Brk/PTK6 signaling in normal and cancer cell models.

@ast

Brk/PTK6 signaling in normal and cancer cell models.

@en

P1433

Q33690176-E7CF64A4-5F14-4BC5-8997-72EF8511F9D7

P1476

Q33690176-E0A5AE42-3B59-4A66-B8A2-F97FCB13A87E

P2093

Q33690176-858E962B-1DDB-437C-8C61-E6EA513200B1

Q33690176-A3F1F775-5A9A-4831-B059-B9594CEB9D48

Q33690176-EBEF8A55-2BFC-4F09-802F-3A1DC4721AA2

P2860

Q33690176-04BFD637-6505-48E3-BAE8-DE4A0C27C0B8

Q33690176-04E304D0-0C93-4149-A9A0-0F4300A7D242

Q33690176-066920BC-96B4-45D7-9C53-66E09DAF35F5

Q33690176-0CD58990-D8B3-497C-8FD7-AE927FE265D4

Q33690176-11B832BB-D2A8-4135-AA33-37F980BBEE86

Q33690176-127ACA67-A8B3-48D7-A8E9-9F3DE3923BE2

Q33690176-1498EE9D-E48B-4BB7-A291-FD2AADC57C3E

Q33690176-18257469-D217-4B0C-AC50-7DC75A1AEF55

Q33690176-1D7EDE42-A201-4EA6-B0D8-ED426794C7D8

Q33690176-1DDF50AF-F6B0-4EB2-9B9A-BFDFCE53B3CF

P304

Q33690176-D812FF4D-1CBB-40D5-8445-B625CB10F78B

P31

Q33690176-E366E8D7-2736-41F5-8A30-E3254CEBF507

P356

Q33690176-2192E14E-7E71-49E7-9E94-CC74B9FC5589

P433

Q33690176-33D4758F-A1A3-4946-BB9F-F2AC47A21B80

P478

Q33690176-2661C7F1-75E0-4369-B3C1-D133F62519A8

P577

Q33690176-B7E91B9E-2BF0-4D64-8253-70E1432D9DA7

P5875

Q33690176-20703502-1D3B-4EAF-A668-704F13DFA6B2

P698

Q33690176-FBF6DFD1-AB46-402F-AFBA-2872145702B1

P932

Q33690176-C71F2BF6-81A6-4780-B71E-44222F4FA2AD

P356

J.COPH.2010.08.007

P1433

Current Opinion in Pharmacology

P1476

Brk/PTK6 signaling in normal and cancer cell models.

@en

P2093

Andrea R Daniel

http://www.w3.org/2001/XMLSchema#string

Carol A Lange

http://www.w3.org/2001/XMLSchema#string

Julie H Ostrander

http://www.w3.org/2001/XMLSchema#string

P2860

Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability

Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6

Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition

BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest

Identification of STAT3 as a specific substrate of breast tumor kinase

CAS/Crk coupling serves as a "molecular switch" for induction of cell migration.

Regulated association of protein kinase B/Akt with breast tumor kinase

Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours

Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin

Solution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domain

P304

662-669

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.COPH.2010.08.007

http://www.w3.org/2001/XMLSchema#string

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

10

http://www.w3.org/2001/XMLSchema#string

P577

2010-09-09T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

46218860

http://www.w3.org/2001/XMLSchema#string

P698

20832360

http://www.w3.org/2001/XMLSchema#string

P932

2981671

http://www.w3.org/2001/XMLSchema#string