Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense - Test2 - elhamkhani - TriplyDB

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

http://www.wikidata.org/entity/Q33694792

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HMGB1-DNA complex-induced autophagy limits AIM2 inflammasome activation through RAGE The Mucosal Immune System and Its Regulation by Autophagy Interactions between Shigella flexneri and the Autophagy Machinery Role of regulatory T cell in the pathogenesis of inflammatory bowel disease Development of autophagy inducers in clinical medicine Inflammatory bowel disease as a model for translating the microbiome Intestinal Antigen-Presenting Cells: Key Regulators of Immune Homeostasis and Inflammation Autophagy in malignant transformation and cancer progression Modulation of inflammation by autophagy: Consequences for human disease ATG16L1: A multifunctional susceptibility factor in Crohn disease Autophagy gene expression profiling identifies a defective microtubule-associated protein light chain 3A mutant in cancer Genetic Variation in Autophagy-Related Genes Influences the Risk and Phenotype of Buruli Ulcer Selective autophagy: xenophagy The unfolded protein response in immunity and inflammation Genetic variation in IBD: progress, clues to pathogenesis and possible clinical utility An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes Caspases: a molecular switch node in the crosstalk between autophagy and apoptosis Current Understanding of Dysbiosis in Disease in Human and Animal Models.Autophagy gene Atg16L1 prevents lethal T cell alloreactivity mediated by dendritic cells.Small-molecule control of cytokine function: new opportunities for treating immune disorders Autophagy, viruses, and intestinal immunity Autophagy mediates tolerance to Staphylococcus aureus alpha-toxin.Pathogenesis of Crohn's disease Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics.Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy ATG16L1 deficiency in macrophages drives clearance of uropathogenic E. coli in an IL-1β-dependent manner MTMR3 risk allele enhances innate receptor-induced signaling and cytokines by decreasing autophagy and increasing caspase-1 activation Role of Autophagy in the Maintenance of Intestinal Homeostasis.Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation.Autophagy in acute kidney injury Intrinsic Defense Mechanisms of the Intestinal Epithelium The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1.Lipocalin 2 prevents intestinal inflammation by enhancing phagocytic bacterial clearance in macrophages.Recent insights into the function of autophagy in cancer.Impaired autophagy in macrophages promotes inflammatory eye disease.Salmonellae interactions with host processes.Intestinal Autophagy and Its Pharmacological Control in Inflammatory Bowel Disease.LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn's disease patients.Links of Autophagy Dysfunction to Inflammatory Bowel Disease Onset

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Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

http://www.wikidata.org/entity/Q33694792

description

2014 nî lūn-bûn

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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2014 թվականի մայիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年學術文章

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name

Atg16L1 T300A variant decrease ...... ecreased antibacterial defense

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Atg16L1 T300A variant decrease ...... ecreased antibacterial defense

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type

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Atg16L1 T300A variant decrease ...... ecreased antibacterial defense

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Atg16L1 T300A variant decrease ...... ecreased antibacterial defense

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prefLabel

Atg16L1 T300A variant decrease ...... ecreased antibacterial defense

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Atg16L1 T300A variant decrease ...... ecreased antibacterial defense

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Proceedings of the National Academy of Sciences of the United States of America

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Atg16L1 T300A variant decrease ...... ecreased antibacterial defense

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Alykhan F Shamji

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Atul K Bhan

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Christine E Becker

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Jason M Norman

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Joanna M Peloquin

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Johnathan Mercer

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Kara G Lassen

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Kara L Conway

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Khushbu K Patel

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P2860

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

Image-based genome-wide siRNA screen identifies selective autophagy factors

Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular Salmonella Typhimurium

Network organization of the human autophagy system

Cloning and analysis of human Apg16L

Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation

Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

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21

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Herbert W. "Skip" Virgin

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Eduardo J Villablanca

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2014-05-12T00:00:00Z

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262267376

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