Understanding the role of the Josephin domain in the PolyUb binding and cleavage properties of ataxin-3.
about
Valosin-containing protein (VCP/p97) is an activator of wild-type ataxin-3Crystal structure of a Josephin-ubiquitin complex: evolutionary restraints on ataxin-3 deubiquitinating activityMode of substrate recognition by the Josephin domain of ataxin-3, which has an endo-type deubiquitinase activityUbe2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIPTrinucleotide repeats: a structural perspectiveAtaxin-3 promotes genome integrity by stabilizing Chk1.Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes.Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117.Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23Characterization of the conformational fluctuations in the Josephin domain of ataxin-3.Versatile roles of k63-linked ubiquitin chains in trafficking.Screening of DUB activity and specificity by MALDI-TOF mass spectrometryBalancing act: deubiquitinating enzymes in the nervous system.Energy landscapes of functional proteins are inherently risky.Allosteric regulation of deubiquitylase activity through ubiquitination.Toward understanding Machado-Joseph diseaseThe deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila melanogaster.Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopyEnzymatic production of mono-ubiquitinated proteins for structural studies: The example of the Josephin domain of ataxin-3.Chaperones in Polyglutamine Aggregation: Beyond the Q-Stretch.Aggregation of polyglutamine-expanded ataxin-3 sequesters its specific interacting partners into inclusions: implication in a loss-of-function pathology.Deubiquitylases from genes to organism.Ataxin-3 protein and RNA toxicity in spinocerebellar ataxia type 3: current insights and emerging therapeutic strategies.The expanding role for chromatin and transcription in polyglutamine disease.Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3.Antisense Oligonucleotide-Mediated Removal of the Polyglutamine Repeat in Spinocerebellar Ataxia Type 3 MiceIt's all about talking: two-way communication between proteasomal and lysosomal degradation pathways via ubiquitin.Destabilizing the AXH Tetramer by Mutations: Mechanisms and Potential Antiaggregation Strategies.Expression and Regulation of Deubiquitinase-Resistant, Unanchored Ubiquitin Chains in Drosophila.
P2860
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P2860
Understanding the role of the Josephin domain in the PolyUb binding and cleavage properties of ataxin-3.
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2010 nî lūn-bûn
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2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Understanding the role of the ...... eavage properties of ataxin-3.
@ast
Understanding the role of the ...... eavage properties of ataxin-3.
@en
type
label
Understanding the role of the ...... eavage properties of ataxin-3.
@ast
Understanding the role of the ...... eavage properties of ataxin-3.
@en
prefLabel
Understanding the role of the ...... eavage properties of ataxin-3.
@ast
Understanding the role of the ...... eavage properties of ataxin-3.
@en
P2860
P50
P1433
P1476
Understanding the role of the ...... eavage properties of ataxin-3.
@en
P2093
Giuseppe Nicastro
Henry L Paulson
P2860
P304
P356
10.1371/JOURNAL.PONE.0012430
P407
P577
2010-08-26T00:00:00Z