A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation.
about
PKC and AKT Modulate cGMP/PKG Signaling Pathway on Platelet Aggregation in Experimental SepsisAkt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)Emerging methodologies to investigate lipid-protein interactionsNovel PI3K/Akt inhibitors screened by the cytoprotective function of human immunodeficiency virus type 1 TatPleckstrin homology domain of Akt kinase: a proof of principle for highly specific and effective non-enzymatic anti-cancer targetAssociation of FKBP51 with priming of autophagy pathways and mediation of antidepressant treatment response: evidence in cells, mice, and humansPKB/Akt partners with Dab2 in albumin endocytosisDevelopment of sulfonamide AKT PH domain inhibitors.A coiled-coil enabled split-luciferase three-hybrid system: applied toward profiling inhibitors of protein kinases.Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain.Small-molecule inhibitors of the PI3K signaling networkGenomic organization and evolution of double minutes/homogeneously staining regions with MYC amplification in human cancer.Suppression of Foxo1 activity and down-modulation of CD62L (L-selectin) in HIV-1 infected resting CD4 T cells.The novel Akt inhibitor API-1 induces c-FLIP degradation and synergizes with TRAIL to augment apoptosis independent of Akt inhibition.The Akt signaling pathway: an emerging therapeutic target in malignant melanoma.Cyclin-Dependent Kinase Inhibitors as Anticancer TherapeuticsEffect of API-1 and FR180204 on cell proliferation and apoptosis in human DLD-1 and LoVo colorectal cancer cells.Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration.The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis.Tinkering outside the kinase ATP box: allosteric (type IV) and bivalent (type V) inhibitors of protein kinases.Intracellular calcium promotes radioresistance of non-small cell lung cancer A549 cells through activating Akt signaling.Differential effects of AKT1(p.E17K) expression on human mammary luminal epithelial and myoepithelial cells.5,7-Dihydroxy-6-Methoxy-Flavonoids Eliminate HIV-1 D3-transfected Cytoprotective Macrophages by Inhibiting the PI3K/Akt Signaling Pathway.c-Jun NH2-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL.The Antiretroviral Agent Nelfinavir Mesylate: A Potential Therapy for Systemic Sclerosis.Human umbilical cord blood mononuclear cell-conditioned media inhibits hypoxic-induced apoptosis in human coronary artery endothelial cells and cardiac myocytes by activation of the survival protein Akt.α-Chaconine and α-Solanine Inhibit RL95-2 Endometrium Cancer Cell Proliferation by Reducing Expression of Akt (Ser473) and ERα (Ser167).
P2860
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P2860
A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
A small molecule inhibits Akt ...... ng Akt membrane translocation.
@ast
A small molecule inhibits Akt ...... ng Akt membrane translocation.
@en
type
label
A small molecule inhibits Akt ...... ng Akt membrane translocation.
@ast
A small molecule inhibits Akt ...... ng Akt membrane translocation.
@en
prefLabel
A small molecule inhibits Akt ...... ng Akt membrane translocation.
@ast
A small molecule inhibits Akt ...... ng Akt membrane translocation.
@en
P2093
P2860
P356
P1476
A small molecule inhibits Akt ...... ng Akt membrane translocation.
@en
P2093
Donghwa Kim
Gerold Bepler
Jin Q Cheng
Qing-Hua Zhou
Said M Sebti
Xia-Meng Sun
P2860
P304
P356
10.1074/JBC.M109.094060
P407
P577
2010-01-12T00:00:00Z