AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas
about
Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2Kinetic mechanism of AKT/PKB enzyme familyThe RAB25 small GTPase determines aggressiveness of ovarian and breast cancersInsulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinaseMechanism of activation of protein kinase B by insulin and IGF-1AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulationPhosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alphaThe PI3K-PDK1 connection: more than just a road to PKBPlatelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through AktTRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating AktAmplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNATherapeutic Implications of Targeting AKT Signaling in MelanomaThe PI3K pathway as drug target in human cancerAkt kinases in breast cancer and the results of adjuvant therapyApoptosis: targets in pancreatic cancerAkt2: a role in breast cancer metastasisIncreased level of phosphorylated akt measured by chemiluminescence-linked immunosorbent assay is a predictor of poor prognosis in primary breast cancer overexpressing ErbB-2.PI3K and AKT: Unfaithful Partners in CancerThe PI3K/AKT Pathway and Renal Cell CarcinomaDiverse mechanisms of AKT pathway activation in human malignancyOvarian cancer biomarker discovery based on genomic approachesTwo membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signalingThe structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutationsEnhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signalingPhase I Study of Apitolisib (GDC-0980), Dual Phosphatidylinositol-3-Kinase and Mammalian Target of Rapamycin Kinase Inhibitor, in Patients with Advanced Solid Tumors.Maximising the potential of AKT inhibitors as anti-cancer treatmentsMLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell linesInhibition of JNK by cellular stress- and tumor necrosis factor alpha-induced AKT2 through activation of the NF kappa B pathway in human epithelial CellsArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survivalMitogenic activation, phosphorylation, and nuclear translocation of protein kinase BbetaPI3K-independent AKT activation in cancers: a treasure trove for novel therapeuticsOncogenic mutations of PIK3CA in human cancersDownregulation of Akt1 inhibits anchorage-independent cell growth and induces apoptosis in cancer cellsNitrosylcobalamin potentiates the anti-neoplastic effects of chemotherapeutic agents via suppression of survival signalingMicroarray reveals complement components are regulated in the serum-deprived rat retinal ganglion cell lineInsulin increases the association of Akt-2 with Glut4-containing vesiclesSpecific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation
P2860
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P2860
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas
description
1992 nî lūn-bûn
@nan
1992 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
AKT2, a putative oncogene enco ...... ed in human ovarian carcinomas
@ast
AKT2, a putative oncogene enco ...... ed in human ovarian carcinomas
@en
AKT2, a putative oncogene enco ...... ed in human ovarian carcinomas
@en-gb
AKT2, a putative oncogene enco ...... ed in human ovarian carcinomas
@nl
type
label
AKT2, a putative oncogene enco ...... ed in human ovarian carcinomas
@ast
AKT2, a putative oncogene enco ...... ed in human ovarian carcinomas
@en
AKT2, a putative oncogene enco ...... ed in human ovarian carcinomas
@en-gb
AKT2, a putative oncogene enco ...... ed in human ovarian carcinomas
@nl
prefLabel
AKT2, a putative oncogene enco ...... ed in human ovarian carcinomas
@ast
AKT2, a putative oncogene enco ...... ed in human ovarian carcinomas
@en
AKT2, a putative oncogene enco ...... ed in human ovarian carcinomas
@en-gb
AKT2, a putative oncogene enco ...... ed in human ovarian carcinomas
@nl
P2093
P2860
P3181
P356
P1476
AKT2, a putative oncogene enco ...... ed in human ovarian carcinomas
@en
P2093
A Bellacosa
A K Godwin
P N Tsichlis
T C Hamilton
T F Franke
P2860
P304
P3181
P356
10.1073/PNAS.89.19.9267
P407
P577
1992-10-01T00:00:00Z