Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes.
about
Targeting protein prenylation in progeriaBlocking protein farnesylation improves nuclear shape abnormalities in keratinocytes of mice expressing the prelamin A variant in Hutchinson-Gilford progeria syndromeFemale Pattern Hair Loss: a clinical and pathophysiological reviewWhen lamins go bad: nuclear structure and diseaseDynamics of lamin-A processing following precursor accumulation.Tipifarnib prevents development of hypoxia-induced pulmonary hypertension.An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria.Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice.Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin.A mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorderInvestigating the purpose of prelamin A processingAn absence of both lamin B1 and lamin B2 in keratinocytes has no effect on cell proliferation or the development of skin and hair.Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases.Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA.Are B-type lamins essential in all mammalian cells?Understanding the roles of nuclear A- and B-type lamins in brain development.Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24Defining the nature of human pluripotent stem cell progeny.Prelamin A processing, accumulation and distribution in normal cells and laminopathy disorders.Disruption of lamin B1 and lamin B2 processing and localization by farnesyltransferase inhibitors.Enhanced SRSF5 Protein Expression Reinforces Lamin A mRNA Production in HeLa Cells and Fibroblasts of Progeria Patients.Novel candidate genes for impaired nephron development in a rat model with inherited nephron deficit and albuminuria.
P2860
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P2860
Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes.
description
2010 nî lūn-bûn
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2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Genetic studies on the functio ...... ferases in skin keratinocytes.
@ast
Genetic studies on the functio ...... ferases in skin keratinocytes.
@en
type
label
Genetic studies on the functio ...... ferases in skin keratinocytes.
@ast
Genetic studies on the functio ...... ferases in skin keratinocytes.
@en
prefLabel
Genetic studies on the functio ...... ferases in skin keratinocytes.
@ast
Genetic studies on the functio ...... ferases in skin keratinocytes.
@en
P2093
P2860
P50
P356
P1476
Genetic studies on the functio ...... sferases in skin keratinocytes
@en
P2093
Hung Trinh
Loren G Fong
Martin O Bergo
Sandy Y Chang
William E Lowry
P2860
P304
P356
10.1093/HMG/DDQ036
P577
2010-01-27T00:00:00Z