A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation. - Test2 - elhamkhani - TriplyDB

A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.

A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.

http://www.wikidata.org/entity/Q33779634

about

PTH receptor-1 signalling-mechanistic insights and therapeutic prospects Structure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptors Regulation of G protein-coupled receptors by allosteric ligands Gaddum Memorial Lecture 2014: receptors as an evolving concept: from switches to biased microprocessors Parathyroid hormone: anabolic and catabolic actions on the skeleton G protein-coupled receptors in cardiac biology: old and new receptors Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Beyond desensitization: physiological relevance of arrestin-dependent signaling.β-Arrestin-1 mediates thyrotropin-enhanced osteoblast differentiation Teaching old receptors new tricks: biasing seven-transmembrane receptors.The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis.Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy.Regulation of the AGS3·G{alpha}i signaling complex by a seven-transmembrane span receptor.The potential for selective pharmacological therapies through biased receptor signaling Discovery of GPCR ligands for probing signal transduction pathways.β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration.Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2.Quantifying ligand bias at seven-transmembrane receptors.Delineation of a conserved arrestin-biased signaling repertoire in vivo.'Biasing' the parathyroid hormone receptor: a novel anabolic approach to increasing bone mass?International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors.The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors Osteoporotic fracture and parathyroid hormone.Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism.Multiple ligand-specific conformations of the β2-adrenergic receptor Calcitonin and calcitonin receptor-like receptors: common themes with family B GPCRs?The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis.Structure-functional selectivity relationship studies of β-arrestin-biased dopamine D₂ receptor agonists.Informatic deconvolution of biased GPCR signaling mechanisms from in vivo pharmacological experimentation.Induction of cardiac fibrosis by β-blocker in G protein-independent and G protein-coupled receptor kinase 5/β-arrestin2-dependent Signaling pathways.Exploring G protein-coupled receptor signaling networks using SILAC-based phosphoproteomics Binding Selectivity of Abaloparatide for PTH-Type-1-Receptor Conformations and Effects on Downstream Signaling.Loss of Gsα in the Postnatal Skeleton Leads to Low Bone Mass and a Blunted Response to Anabolic Parathyroid Hormone Therapy Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm.G Protein-coupled Receptor Biased Agonism.Human Neuropeptide S Receptor Is Activated via a Gαq Protein-biased Signaling Cascade by a Human Neuropeptide S Analog Lacking the C-terminal 10 Residues.Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors Therapeutic potential of β-arrestin- and G protein-biased agonists.Acting on Hormone Receptors with Minimal Side Effect on Cell Proliferation: A Timely Challenge Illustrated with GLP-1R and GPER Multiple Transduction Pathways Mediate Thyrotropin Receptor Signaling in Preosteoblast-Like Cells.

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A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.

http://www.wikidata.org/entity/Q33779634

description

2009 nî lūn-bûn

@nan

2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

@zh-hk

2009年論文

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2009年論文

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2009年论文

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name

A beta-arrestin-biased agonist ...... ndent of G protein activation.

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A beta-arrestin-biased agonist ...... ndent of G protein activation.

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type

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A beta-arrestin-biased agonist ...... ndent of G protein activation.

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A beta-arrestin-biased agonist ...... ndent of G protein activation.

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A beta-arrestin-biased agonist ...... ndent of G protein activation.

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A beta-arrestin-biased agonist ...... ndent of G protein activation.

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SCITRANSLMED.3000071

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Science Translational Medicine

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A beta-arrestin-biased agonist ...... endent of G protein activation

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Diane Gesty-Palmer

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Leonor Corsino

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Ling Yuan

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Pat Flannery

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Robert J Lefkowitz

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Robert Spurney

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P2860

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds

Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3

Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system

Transduction of receptor signals by beta-arrestins

Enhanced morphine analgesia in mice lacking beta-arrestin 2

Anabolic effects of a G protein-coupled receptor kinase inhibitor expressed in osteoblasts

Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee

Beta-arrestins and cell signaling

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1

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43023124

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2852200

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