A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.
about
PTH receptor-1 signalling-mechanistic insights and therapeutic prospectsStructure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptorsRegulation of G protein-coupled receptors by allosteric ligandsGaddum Memorial Lecture 2014: receptors as an evolving concept: from switches to biased microprocessorsParathyroid hormone: anabolic and catabolic actions on the skeletonG protein-coupled receptors in cardiac biology: old and new receptorsSeven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Beyond desensitization: physiological relevance of arrestin-dependent signaling.β-Arrestin-1 mediates thyrotropin-enhanced osteoblast differentiationTeaching old receptors new tricks: biasing seven-transmembrane receptors.The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis.Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy.Regulation of the AGS3·G{alpha}i signaling complex by a seven-transmembrane span receptor.The potential for selective pharmacological therapies through biased receptor signalingDiscovery of GPCR ligands for probing signal transduction pathways.β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration.Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2.Quantifying ligand bias at seven-transmembrane receptors.Delineation of a conserved arrestin-biased signaling repertoire in vivo.'Biasing' the parathyroid hormone receptor: a novel anabolic approach to increasing bone mass?International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors.The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptorsOsteoporotic fracture and parathyroid hormone.Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism.Multiple ligand-specific conformations of the β2-adrenergic receptorCalcitonin and calcitonin receptor-like receptors: common themes with family B GPCRs?The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis.Structure-functional selectivity relationship studies of β-arrestin-biased dopamine D₂ receptor agonists.Informatic deconvolution of biased GPCR signaling mechanisms from in vivo pharmacological experimentation.Induction of cardiac fibrosis by β-blocker in G protein-independent and G protein-coupled receptor kinase 5/β-arrestin2-dependent Signaling pathways.Exploring G protein-coupled receptor signaling networks using SILAC-based phosphoproteomicsBinding Selectivity of Abaloparatide for PTH-Type-1-Receptor Conformations and Effects on Downstream Signaling.Loss of Gsα in the Postnatal Skeleton Leads to Low Bone Mass and a Blunted Response to Anabolic Parathyroid Hormone TherapyMolecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm.G Protein-coupled Receptor Biased Agonism.Human Neuropeptide S Receptor Is Activated via a Gαq Protein-biased Signaling Cascade by a Human Neuropeptide S Analog Lacking the C-terminal 10 Residues.Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptorsTherapeutic potential of β-arrestin- and G protein-biased agonists.Acting on Hormone Receptors with Minimal Side Effect on Cell Proliferation: A Timely Challenge Illustrated with GLP-1R and GPERMultiple Transduction Pathways Mediate Thyrotropin Receptor Signaling in Preosteoblast-Like Cells.
P2860
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P2860
A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
A beta-arrestin-biased agonist ...... ndent of G protein activation.
@ast
A beta-arrestin-biased agonist ...... ndent of G protein activation.
@en
type
label
A beta-arrestin-biased agonist ...... ndent of G protein activation.
@ast
A beta-arrestin-biased agonist ...... ndent of G protein activation.
@en
prefLabel
A beta-arrestin-biased agonist ...... ndent of G protein activation.
@ast
A beta-arrestin-biased agonist ...... ndent of G protein activation.
@en
P2093
P2860
P1476
A beta-arrestin-biased agonist ...... endent of G protein activation
@en
P2093
Diane Gesty-Palmer
Leonor Corsino
Pat Flannery
Robert J Lefkowitz
Robert Spurney
P2860
P356
10.1126/SCITRANSLMED.3000071
P407
P577
2009-10-01T00:00:00Z