Advances in the computational development of DNA methyltransferase inhibitors.
about
Computer-aided Molecular Design of Compounds Targeting Histone Modifying EnzymesModelling three-dimensional protein structures for applications in drug design.Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectivesNimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia.Perspectives on the discovery of small-molecule modulators for epigenetic processes.Design, synthesis and biological evaluation of 4-amino-N- (4-aminophenyl)benzamide analogues of quinoline-based SGI-1027 as inhibitors of DNA methylation.In silico design of the first DNA-independent mechanism-based inhibitor of mammalian DNA methyltransferase Dnmt1.DNA cytosine methylation: structural and thermodynamic characterization of the epigenetic marking mechanism.Specific Inhibition of DNMT3A/ISGF3γ Interaction Increases the Temozolomide Efficiency to Reduce Tumor GrowthEpigenetic drug discovery: targeting DNA methyltransferases.Molecular modeling of inhibitors of human DNA methyltransferase with a crystal structure: discovery of a novel DNMT1 inhibitor.DNA methyltransferase inhibitors in acute myeloid leukemia: discovery, design and first therapeutic experiences.Lost in translation. New unexplored avenues for neuropsychopharmacology: epigenetics and microRNAs.Epigenetic Modulations of Induced Pluripotent Stem Cells: Novel Therapies and Disease ModelsRationalization of activity cliffs of a sulfonamide inhibitor of DNA methyltransferases with induced-fit docking.Activity landscape of DNA methyltransferase inhibitors bridges chemoinformatics with epigenetic drug discovery.Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells.Docking of a novel DNA methyltransferase inhibitor identified from high-throughput screening: insights to unveil inhibitors in chemical databases.Hypermethylation-mediated transcriptional repression of TMPRSS2 in androgen receptor-negative prostate cancer cells.Computer-guided discovery of epigenetics drugs: molecular modeling and identification of inhibitors of DNMT1.Procaine is a specific DNA methylation inhibitor with anti-tumor effect for human gastric cancer.Trimethylaurintricarboxylic acid inhibits human DNA methyltransferase 1: insights from enzymatic and molecular modeling studies.Toward drug repurposing in epigenetics: olsalazine as a hypomethylating compound active in a cellular context.From natural products to drugs for epimutation computer-aided drug design.Specific inhibition of DNMT1/CFP1 reduces cancer phenotypes and enhances chemotherapy effectiveness.Ensemble-Based Virtual Screening and Experimental Validation of Inhibitors Targeting a Novel Site of Human DNMT1.Copaifera of the Neotropics: A Review of the Phytochemistry and Pharmacology.
P2860
Q28083849-6817A021-583F-439A-928D-3841DBE4C647Q30355473-EF5CC969-63A7-4FE2-A8D0-AEE534632241Q30570945-362D791D-012B-47C7-AB1A-C378DC5AB010Q30848149-197C9C98-65B2-4982-B23A-C2DFD648C4E2Q34185471-AC9AF54C-4E3C-41AA-889C-009F493702D6Q35863536-92690819-17B8-4CE4-AB1F-6BE6C4673604Q36343389-6169054F-C413-47D8-B1E8-6A66430BF421Q36941741-4376F595-ACA1-4087-BA09-BD4EFA740426Q37290420-E4F5CB32-AA85-431C-AEAC-88261250CF17Q37941536-5E72E1B8-84D8-4DFF-B2DE-C6D841075BF3Q38011287-C65988B7-980C-410A-8018-8569BDAA5049Q38040883-AF94CB28-6BB8-47EF-AAC8-99AAD1876078Q38068561-2373EE56-66F5-4C19-81BD-F6B0454FB50DQ38104345-D8EE6B82-3B5C-408D-ADA0-878EA0427697Q38346032-E6179CA9-4A91-4A81-BC64-CC0DE3B0F3E8Q38569747-1E2206C2-EB60-485A-970D-2786F0459104Q39023375-48FA5729-87DF-4855-B8B0-731CE9C3CE02Q45191168-8D0880D5-C86E-4EFE-8211-5580E73157A8Q45753064-4790EDB8-5477-478F-8B36-422AB0FA3ED2Q45789020-B57E7D91-0138-447A-AC80-BED3F47796C6Q47962113-ADC73CF8-9B20-4418-8495-DD6228BD1A21Q48973690-B8D7F291-E542-4BB2-9E01-C99F865BFC34Q51755762-0B0F5054-8F2F-4DEC-A922-11C4B0AC57BFQ51825702-9A40B578-B077-4A83-98E1-3914FDD7CD3BQ52652744-AA11E66C-8289-438A-A4C7-2A960C598B82Q53185257-5A2FC30F-250C-46BB-B6E6-6DFB14445F27Q55083491-A036AEF6-52DE-4341-9E5D-F27DA838C7E7
P2860
Advances in the computational development of DNA methyltransferase inhibitors.
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Advances in the computational development of DNA methyltransferase inhibitors.
@ast
Advances in the computational development of DNA methyltransferase inhibitors.
@en
type
label
Advances in the computational development of DNA methyltransferase inhibitors.
@ast
Advances in the computational development of DNA methyltransferase inhibitors.
@en
prefLabel
Advances in the computational development of DNA methyltransferase inhibitors.
@ast
Advances in the computational development of DNA methyltransferase inhibitors.
@en
P1433
P1476
Advances in the computational development of DNA methyltransferase inhibitors.
@en
P2093
José L Medina-Franco
Thomas Caulfield
P304
P356
10.1016/J.DRUDIS.2011.02.003
P577
2011-02-16T00:00:00Z