TR-FRET assays of Huntingtin protein fragments reveal temperature and polyQ length-dependent conformational changes.
about
Polyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopyAnti-PolyQ Antibodies Recognize a Short PolyQ Stretch in Both Normal and Mutant Huntingtin Exon 1.Polyglutamine expansion affects huntingtin conformation in multiple Huntington's disease models.A toxic mutant huntingtin species is resistant to selective autophagy.Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models.Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation.Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein.The COOH-terminal domain of huntingtin interacts with RhoGEF kalirin and modulates cell survival.
P2860
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P2860
TR-FRET assays of Huntingtin protein fragments reveal temperature and polyQ length-dependent conformational changes.
description
2014 nî lūn-bûn
@nan
2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
TR-FRET assays of Huntingtin p ...... endent conformational changes.
@ast
TR-FRET assays of Huntingtin p ...... endent conformational changes.
@en
type
label
TR-FRET assays of Huntingtin p ...... endent conformational changes.
@ast
TR-FRET assays of Huntingtin p ...... endent conformational changes.
@en
prefLabel
TR-FRET assays of Huntingtin p ...... endent conformational changes.
@ast
TR-FRET assays of Huntingtin p ...... endent conformational changes.
@en
P2093
P2860
P356
P1433
P1476
TR-FRET assays of Huntingtin p ...... endent conformational changes.
@en
P2093
Mingxing Lu
Qingnan Liang
Xiaotian Cui
Yijian Liang
P2860
P2888
P356
10.1038/SREP05601
P407
P50
P577
2014-07-07T00:00:00Z
P5875
P6179
1024732801