A screen for enhancers of clearance identifies huntingtin as a heat shock protein 90 (Hsp90) client protein.
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Paralog Specific Hsp90 Inhibitors - A Brief History and a Bright FutureTargeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseasesProtein homeostasis as a therapeutic target for diseases of protein conformationModeling Huntington's disease with induced pluripotent stem cellsTransportable, Chemical Genetic Methodology for the Small Molecule-Mediated Inhibition of Heat Shock Factor 1TR-FRET assays of Huntingtin protein fragments reveal temperature and polyQ length-dependent conformational changes.Fragments of HdhQ150 mutant huntingtin form a soluble oligomer pool that declines with aggregate deposition upon agingA phenotypic screening assay for modulators of huntingtin-induced transcriptional dysregulation.Molecular interaction between the chaperone Hsc70 and the N-terminal flank of huntingtin exon 1 modulates aggregationDevelopment of an ELISA assay for the quantification of soluble huntingtin in human blood cells.Cytoplasmic Ubiquitin-Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine-Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone.Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity.Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradationExpanded polyglutamine-containing N-terminal huntingtin fragments are entirely degraded by mammalian proteasomes.Stressing Out Hsp90 in Neurotoxic Proteinopathies.Cytotoxicity of mutant huntingtin fragment in yeast can be modulated by the expression level of wild type huntingtin fragment.The role of amyloidogenic protein oligomerization in neurodegenerative disease.Opportunities and challenges for molecular chaperone modulation to treat protein-conformational brain diseasesExperimental models for identifying modifiers of polyglutamine-induced aggregation and neurodegeneration.Advances in huntington disease drug discovery: novel approaches to model disease phenotypes.Barcoding heat shock proteins to human diseases: looking beyond the heat shock responseiPSC-based drug screening for Huntington's disease.Discovery of Therapeutic Approaches for Polyglutamine Diseases: A Summary of Recent Efforts.Modulation of Molecular Chaperones in Huntington's Disease and Other Polyglutamine Disorders.High-throughput screen of natural product extracts in a yeast model of polyglutamine proteotoxicity.Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention.The anticancer drug AUY922 generates a proteomics fingerprint that is highly conserved among structurally diverse Hsp90 inhibitors.Heat shock protein 90 functions to stabilize and activate the testis-specific serine/threonine kinases, a family of kinases essential for male fertilityHSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19.Proteostasis in Huntington's disease: disease mechanisms and therapeutic opportunities.Targeting Gpr52 lowers mutant HTT levels and rescues Huntington's disease-associated phenotypes.Quantification of Total and Mutant Huntingtin Protein Levels in Biospecimens Using a Novel alphaLISA Assay
P2860
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P2860
A screen for enhancers of clearance identifies huntingtin as a heat shock protein 90 (Hsp90) client protein.
description
2011 nî lūn-bûn
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2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
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2011年论文
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name
A screen for enhancers of clea ...... ein 90 (Hsp90) client protein.
@ast
A screen for enhancers of clea ...... ein 90 (Hsp90) client protein.
@en
type
label
A screen for enhancers of clea ...... ein 90 (Hsp90) client protein.
@ast
A screen for enhancers of clea ...... ein 90 (Hsp90) client protein.
@en
prefLabel
A screen for enhancers of clea ...... ein 90 (Hsp90) client protein.
@ast
A screen for enhancers of clea ...... ein 90 (Hsp90) client protein.
@en
P2093
P2860
P356
P1476
A screen for enhancers of clea ...... tein 90 (Hsp90) client protein
@en
P2093
Andreas Weiss
Barbara Baldo
Christian N Parker
Miriam Bibel
P2860
P304
P356
10.1074/JBC.M111.294801
P407
P577
2011-11-28T00:00:00Z