An antisense microwalk reveals critical role of an intronic position linked to a unique long-distance interaction in pre-mRNA splicing
about
LNA/DNA mixmer-based antisense oligonucleotides correct alternative splicing of the SMN2 gene and restore SMN protein expression in type 1 SMA fibroblastsOptimal antisense target reducing INS intron 1 retention is adjacent to a parallel G quadruplex.TIA1 prevents skipping of a critical exon associated with spinal muscular atrophy.SMN-inducing compounds for the treatment of spinal muscular atrophy.A multi-exon-skipping detection assay reveals surprising diversity of splice isoforms of spinal muscular atrophy genes.ISS-N1 makes the First FDA-approved Drug for Spinal Muscular Atrophy.Advances in therapeutic development for spinal muscular atrophy.Alternative splicing in spinal muscular atrophy underscores the role of an intron definition model.The role of short RNA loops in recognition of a single-hairpin exon derived from a mammalian-wide interspersed repeat.Splicing regulation in spinal muscular atrophy by an RNA structure formed by long-distance interactions.Mechanistic principles of antisense targets for the treatment of spinal muscular atrophyAn intronic structure enabled by a long-distance interaction serves as a novel target for splicing correction in spinal muscular atrophySpinal muscular atrophy: an update on therapeutic progressAntisense oligonucleotide mediated therapy of spinal muscular atrophySpinal muscular atrophy: a motor neuron disorder or a multi-organ disease?Diverse role of survival motor neuron protein.How the discovery of ISS-N1 led to the first medical therapy for spinal muscular atrophyDevelopmental regulation of SMN expression: pathophysiological implications and perspectives for therapy development in spinal muscular atrophy.A novel splicing silencer generated by DMD exon 45 deletion junction could explain upstream exon 44 skipping that modifies dystrophinopathy.Activation of a cryptic 5' splice site reverses the impact of pathogenic splice site mutations in the spinal muscular atrophy gene.A Multilayered Control of the Human Survival Motor Neuron Gene Expression by Alu Elements.Mechanism of Splicing Regulation of Spinal Muscular Atrophy Genes.
P2860
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P2860
An antisense microwalk reveals critical role of an intronic position linked to a unique long-distance interaction in pre-mRNA splicing
description
2010 nî lūn-bûn
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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年论文
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name
An antisense microwalk reveals ...... teraction in pre-mRNA splicing
@ast
An antisense microwalk reveals ...... teraction in pre-mRNA splicing
@en
type
label
An antisense microwalk reveals ...... teraction in pre-mRNA splicing
@ast
An antisense microwalk reveals ...... teraction in pre-mRNA splicing
@en
prefLabel
An antisense microwalk reveals ...... teraction in pre-mRNA splicing
@ast
An antisense microwalk reveals ...... teraction in pre-mRNA splicing
@en
P2093
P2860
P356
P1433
P1476
An antisense microwalk reveals ...... teraction in pre-mRNA splicing
@en
P2093
Dhruva Bhattacharya
Katrin Hollinger
Natalia N Singh
Ravindra N Singh
P2860
P304
P356
10.1261/RNA.2154310
P407
P577
2010-04-22T00:00:00Z