Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells. - Test2 - elhamkhani - TriplyDB

Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.

Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.

http://www.wikidata.org/entity/Q33873915

about

DUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic Targets Exploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer Therapy Deubiquitinating enzymes as oncotargets Allosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20 ID1 promotes breast cancer metastasis by S100A9 regulation.Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer.Screening of DUB activity and specificity by MALDI-TOF mass spectrometry Cheminformatics models based on machine learning approaches for design of USP1/UAF1 abrogators as anticancer agents.ID proteins regulate diverse aspects of cancer progression and provide novel therapeutic opportunities.Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression.Ubiquitin-Specific Proteases as Druggable Targets.A novel role for the deubiquitinase USP1 in the control of centrosome duplication.The isopeptidase inhibitor 2cPE triggers proteotoxic stress and ATM activation in chronic lymphocytic leukemia cells.In vivo genome-wide binding of Id2 to E2F4 target genes as part of a reversible program in mice liver.Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer.DUBs, the regulation of cell identity and disease.Counteracting PINK/Parkin Deficiency in the Activation of Mitophagy: A Potential Therapeutic Intervention for Parkinson's Disease.Decision for cell fate: deubiquitinating enzymes in cell cycle checkpoint.Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models.Ubiquitin-specific protease 39 is overexpressed in human lung cancer and promotes tumor cell proliferation in vitro.Chemical and semisynthetic approaches to study and target deubiquitinases.Targeting Deubiquitinating Enzymes in Glioblastoma Multiforme: Expectations and Challenges.Cell Lysate-Based AlphaLISA Deubiquitinase Assay Platform for Identification of Small Molecule Inhibitors.Mutations in the 'Fingers' subdomain of the deubiquitinase USP1 modulate its function and activity.Structure-function analysis of USP1: insights into the role of Ser313 phosphorylation site and the effect of cancer-associated mutations on autocleavage.Identification of deubiquitinase targets of isothiocyanates using SILAC-assisted quantitative mass spectrometry.DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway.Targeting deubiquitinating enzymes in cancer stem cells.Metal-based proteasomal deubiquitinase inhibitors as potential anticancer agents.Blockade of Deubiquitylating Enzyme USP1 Inhibits DNA Repair and Triggers Apoptosis in Multiple Myeloma Cells.The novel anti-androgen candidate galeterone targets deubiquitinating enzymes, USP12 and USP46, to control prostate cancer growth and survival.Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal Rare Genetic Diseases with Defects in DNA Repair: Opportunities and Challenges in Orphan Drug Development for Targeted Cancer Therapy

P2860

Q26741797-D3B234A1-6CBD-46E8-8979-613496BEA81A Q26801593-17823E18-2F0D-45B7-91EF-2B42B1018D94 Q27026189-C7B1CB23-8F26-4E44-803F-AB397B9DA0CD Q28117407-72CEFC8E-83F9-44FD-8B92-B4DF1CD560A0 Q34177858-0B967ADF-C6FE-4DBA-B7C3-6F3E7A30AB25 Q34313778-84999052-3813-4A83-B8B3-2C415E0F10B0 Q35232335-12CC1659-82B6-4A71-80CC-178F4D029E6B Q35593976-B14285C9-6A44-4F63-95D3-0B01CDE214AF Q35618867-1F2A6A13-64DD-4FAD-AE3D-256E77BE17EC Q35689467-5426B6C4-446C-4A57-BE3E-52834F9FD462 Q35904946-949EE4AB-D8B6-439D-8040-56A0BA876D00 Q36509580-1B991E5A-A52D-4543-A98F-1D55B9BA9A71 Q37324515-E10F7C34-56FD-463E-8179-E479850CF4D3 Q37564440-CF06FCB9-43D9-4319-BA52-11518B8E5BB9 Q38191472-BCAF5AA6-D90D-4428-AAFC-EB7CA0EBEA6D Q38262067-C5B36B25-4811-4A00-A116-BBD81A5CE934 Q38336126-3D4E4469-6948-4D4F-B258-5D27C0450A52 Q38620223-295462B6-15EE-429D-A0B4-D4DA1E940EEC Q38695071-BA6D10AB-C5E9-48A7-AE98-1857737EFCC4 Q38743296-6D0F0063-A981-43CA-8349-326D311BDEBB Q38746245-7DDC8439-4BC0-4ABD-B28D-64631F82F9F6 Q38799376-F70BB2F1-7064-4E66-95A8-53143F7A60B1 Q38989377-3A083F4A-42D5-4A84-9BB4-0CDC645195C8 Q40072442-F5F53520-8CF2-4FD5-A3A2-708F6CC8A755 Q40116814-77DBEE76-0700-4873-A0C5-6F6C7AA5F9AE Q41285125-5C93D08E-D617-4075-BCF5-CCBFE9B3FAAC Q41612750-C30D26EF-F70E-4458-80F1-7C0B09A48FB4 Q42374449-9D335A37-B8FF-442B-A25F-095DD058385E Q44948244-CB1356C9-F7C6-4AB3-B5AC-CAF0FE549FBB Q47098444-6995C02C-DD92-4AFB-8C22-05311B7EF927 Q50233866-2983CCC1-263E-42B1-8567-391D2A673C05 Q55129906-EDA068D1-F7CF-4F99-B5B7-71F6EE0BA6FC Q58751747-92B49DAF-2731-49A1-AE83-C3868547CCE4 Q58773614-BC79E99A-F987-437C-B974-DE50667491DE

P2860

Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.

http://www.wikidata.org/entity/Q33873915

description

2013 nî lūn-bûn

@nan

2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.

@ast

Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.

@en

type

label

Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.

@ast

Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.

@en

prefLabel

Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.

@ast

Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.

@en

P1433

Q33873915-4E76262E-133D-4D74-AE62-175B52487AA3

P1476

Q33873915-1F4536C0-F6EB-4326-B751-933BED730170

P2093

Q33873915-010DEB94-59BE-4B18-BB34-0EEE44EF692A

Q33873915-08487B86-182F-403C-BC44-C1C2593BAE14

Q33873915-0B63FAE9-5A04-47DC-AB4E-82CF2E78EC85

Q33873915-0C85053A-9911-4F3E-9D0D-2CDAF04235AC

Q33873915-4A69AE85-F1F5-4F4C-A5EA-B51E8879F17C

Q33873915-4CE65EC7-E749-4EA0-B690-0C75AAF798AA

Q33873915-59FAE5E6-15EE-4ACB-A591-5300FF5F89A6

Q33873915-A3BF033C-9041-418C-B9CE-1061008427C3

Q33873915-CDC105F7-560B-41E7-85DF-B57A53D6F6D0

Q33873915-E5871814-F87F-4526-8473-818DD2A1BA8E

P2860

Q33873915-083EF833-FC43-4150-8328-2BE48CC8578F

Q33873915-0AF21C43-CA28-4FA0-A462-A5CF8262028C

Q33873915-0F0EC151-DB03-4111-A290-0F5568EF7F99

Q33873915-10647BB8-FADF-44FE-A684-03D84C9ACB20

Q33873915-1F45885F-94CD-4FCB-A8C6-BCAFCBC126C5

Q33873915-24171FB2-CA7B-463A-B5D1-07E9681BF287

Q33873915-284E4D24-ED49-4F3B-982A-354F4BC1E1F0

Q33873915-2979E658-397D-4F59-A087-5D810CE0C618

Q33873915-2E470100-9A09-4DD6-940C-6CC7AD87E448

Q33873915-31CDB4AF-C673-473C-B7D5-60DDC7554EC1

P304

Q33873915-83CD7AE5-6AE6-498D-92C4-5514111D9519

P31

Q33873915-566C8C00-B620-4BA0-98CB-9990532BE965

P356

Q33873915-B6BB4025-1500-49E7-894F-5FF38F89964C

P433

Q33873915-1BFFA247-22D8-447F-AEB4-5060E1DCA358

P478

Q33873915-3913FCD0-794E-4512-8B36-DAA0B14F1272

P50

Q33873915-BF3E9345-0C7C-43AB-B71D-E33C76472C33

P577

Q33873915-0469DC42-647B-4936-81D5-97B74C41048A

P698

Q33873915-DC65C81C-4063-42E8-AC30-CF71D76B944D

P921

Q33873915-11A35570-64FF-427C-9B8E-59DECBF8C1D0

P932

Q33873915-70FBC5E4-F38D-4996-B140-E60E8444CFE9

P356

1535-7163.MCT-13-0103-T

P1433

Molecular Cancer Therapeutics

P1476

Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells

@en

P2093

Alan D D'Andrea

http://www.w3.org/2001/XMLSchema#string

Eunmi Park

http://www.w3.org/2001/XMLSchema#string

Grace Hsieh

http://www.w3.org/2001/XMLSchema#string

Gregory D Cuny

http://www.w3.org/2001/XMLSchema#string

Helena Mistry

http://www.w3.org/2001/XMLSchema#string

Ilene Galinsky

http://www.w3.org/2001/XMLSchema#string

Kalindi Parmar

http://www.w3.org/2001/XMLSchema#string

Nathanael S Gray

http://www.w3.org/2001/XMLSchema#string

Richard M Stone

http://www.w3.org/2001/XMLSchema#string

Sara J Buhrlage

http://www.w3.org/2001/XMLSchema#string

P2860

A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway

UAF1 is a subunit of multiple deubiquitinating enzyme complexes

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

Regulation of monoubiquitinated PCNA by DUB autocleavage

WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex

Degradation of Id proteins by the ubiquitin-proteasome pathway

Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts

Id proteins in development, cell cycle and cancer

Id proteins at the cross-road of development and cancer

Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway

P304

2651-2662

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1158/1535-7163.MCT-13-0103-T

http://www.w3.org/2001/XMLSchema#string

P433

12

http://www.w3.org/2001/XMLSchema#string

P478

12

http://www.w3.org/2001/XMLSchema#string

P50

P577

2013-10-15T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

24130053

http://www.w3.org/2001/XMLSchema#string

P921

P932

4089878

http://www.w3.org/2001/XMLSchema#string