Ca(2+)-desensitizing effect of a deletion mutation Delta K210 in cardiac troponin T that causes familial dilated cardiomyopathy. - Test2 - elhamkhani - TriplyDB

Ca(2+)-desensitizing effect of a deletion mutation Delta K210 in cardiac troponin T that causes familial dilated cardiomyopathy.

Ca(2+)-desensitizing effect of a deletion mutation Delta K210 in cardiac troponin T that causes familial dilated cardiomyopathy.

http://www.wikidata.org/entity/Q33894656

about

Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T Clinical and functional characterization of TNNT2 mutations identified in patients with dilated cardiomyopathy Thin filament mutations: developing an integrative approach to a complex disorder Functional consequence of mutation in rat cardiac troponin T is affected differently by myosin heavy chain isoforms Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy.Thin filament incorporation of an engineered cardiac troponin C variant (L48Q) enhances contractility in intact cardiomyocytes from healthy and infarcted hearts.Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alpha-cardiac myosin in the laser trap assay.The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy.Rescue of familial cardiomyopathies by modifications at the level of sarcomere and Ca2+ fluxes.Genotype-specific pathogenic effects in human dilated cardiomyopathy.Cardiac troponin T (TNNT2) mutations in chinese dilated cardiomyopathy patients Hypertrophic cardiomyopathy: from genetics to treatment Experimental therapies in hypertrophic cardiomyopathy Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C.Molecular etiology of idiopathic cardiomyopathy.Recurrent and founder mutations in the Netherlands: mutation p.K217del in troponin T2, causing dilated cardiomyopathy.Multistep ion channel remodeling and lethal arrhythmia precede heart failure in a mouse model of inherited dilated cardiomyopathy.Late onset sporadic dilated cardiomyopathy caused by a cardiac troponin T mutation.Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates.Biological actions of green tea catechins on cardiac troponin C.Familial dilated cardiomyopathy caused by an alpha-tropomyosin mutation: the distinctive natural history of sarcomeric dilated cardiomyopathy.Usefulness of running wheel for detection of congestive heart failure in dilated cardiomyopathy mouse model.Molecular mechanisms of inherited cardiomyopathies.Functional characterization of TNNC1 rare variants identified in dilated cardiomyopathy.Stage-dependent benefits and risks of pimobendan in mice with genetic dilated cardiomyopathy and progressive heart failure.Insights into restrictive cardiomyopathy from clinical and animal studies.The mutations associated with dilated cardiomyopathy Gene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium Desensitization The miscommunicative cardiac cell: when good proteins go bad.Significance of troponin dynamics for Ca2+-mediated regulation of contraction and inherited cardiomyopathy.Myofibrillar remodeling in cardiac hypertrophy, heart failure and cardiomyopathies.Analysis of the molecular pathogenesis of cardiomyopathy-causing cTnT mutants I79N, ΔE96, and ΔK210.A myosin activator improves actin assembly and sarcomere function of human-induced pluripotent stem cell-derived cardiomyocytes with a troponin T point mutation.Cardiac-specific ablation of Cypher leads to a severe form of dilated cardiomyopathy with premature death.Molecular basis of hereditary cardiomyopathy: abnormalities in calcium sensitivity, stretch response, stress response and beyond.Insights and Challenges of Multi-Scale Modeling of Sarcomere Mechanics in cTn and Tm DCM Mutants-Genotype to Cellular Phenotype.Inherited cardiomyopathies caused by troponin mutations.Myofilament dysfunction as an emerging mechanism of volume overload heart failure.Experimental models of inherited cardiomyopathy and its therapeutics.Where Does Inflammation Fit?

P2860

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P2860

Ca(2+)-desensitizing effect of a deletion mutation Delta K210 in cardiac troponin T that causes familial dilated cardiomyopathy.

http://www.wikidata.org/entity/Q33894656

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Proceedings of the National Academy of Sciences of the United States of America

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F Takahashi-Yanaga

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P2860

Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy

Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein

Mutations that alter the surface charge of alpha-tropomyosin are associated with dilated cardiomyopathy

Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy

Actin mutations in dilated cardiomyopathy, a heritable form of heart failure

Mutations in the human delta-sarcoglycan gene in familial and sporadic dilated cardiomyopathy

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy

Functional consequences of the deletion mutation deltaGlu160 in human cardiac troponin T

Functional consequences of a carboxyl terminal missense mutation Arg278Cys in human cardiac troponin T

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117405

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