A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation.
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Zeranol down-regulates p53 expression in primary cultured human breast cancer epithelial cells through epigenetic modificationTrials with 'epigenetic' drugs: an updateEpigenetic modulators as therapeutic targets in prostate cancerMolecular modeling studies of the novel inhibitors of DNA methyltransferases SGI-1027 and CBC12: implications for the mechanism of inhibition of DNMTsProperly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity.Epigenetics in cancerCharacterizing DNA methyltransferases with an ultrasensitive luciferase-linked continuous assayCancer/testis antigen CAGE exerts negative regulation on p53 expression through HDAC2 and confers resistance to anti-cancer drugs.Targeting DNA methylation for epigenetic therapy.Cancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells.Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1.Reduced susceptibility of DNA methyltransferase 1 hypomorphic (Dnmt1N/+) mice to hepatic steatosis upon feeding liquid alcohol diet.Small-molecular modulators of cancer-associated epigenetic mechanisms.Methylation-associated silencing of MicroRNA-335 contributes tumor cell invasion and migration by interacting with RASA1 in gastric cancerAn ultrasensitive high throughput screen for DNA methyltransferase 1-targeted molecular probesA sensitive microfluidic platform for a high throughput DNA methylation assay.WIF1 is a frequent target for epigenetic silencing in squamous cell carcinoma of the cervixTreatment of breast cancer cells with DNA demethylating agents leads to a release of Pol II stalling at genes with DNA-hypermethylated regions upstream of TSS.Epigenetics in diagnosis, prognostic assessment and treatment of cancer: an update.Kinetics of DNA methylation inheritance by the Dnmt1-including complexes during the cell cycle.Design, synthesis and biological evaluation of 4-amino-N- (4-aminophenyl)benzamide analogues of quinoline-based SGI-1027 as inhibitors of DNA methylation.RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylationDepletion of the cisplatin targeted HMGB-box factor UBF selectively induces p53-independent apoptotic death in transformed cells.DNA-intercalators causing rapid re-expression of methylated and silenced genes in cancer cellsEpigenetics and colorectal cancer pathogenesisDiscovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells.Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells.DNA Methylation Targeting: The DNMT/HMT Crosstalk Challenge.The hunt for the epiallele.Epigenetic mechanisms in senescence, immortalisation and cancer.The application of delivery systems for DNA methyltransferase inhibitors.Epigenetic drug discovery: targeting DNA methyltransferases.Role of epigenomics in ovarian and endometrial cancers.Emerging promise of epigenetics and DNA methylation for the diagnosis and management of women's cancers.Epigenetics and blood disorders.DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studies.Epigenetic aspects of MDS and its molecular targeted therapy.Drugging the undruggable: transcription therapy for cancer.Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors.DNA methylation profiles in cancer diagnosis and therapeutics.
P2860
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P2860
A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation.
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
A new class of quinoline-based ...... and inducing its degradation.
@ast
A new class of quinoline-based ...... and inducing its degradation.
@en
type
label
A new class of quinoline-based ...... and inducing its degradation.
@ast
A new class of quinoline-based ...... and inducing its degradation.
@en
prefLabel
A new class of quinoline-based ...... and inducing its degradation.
@ast
A new class of quinoline-based ...... and inducing its degradation.
@en
P2093
P2860
P1433
P1476
A new class of quinoline-based ...... and inducing its degradation.
@en
P2093
Darby G Brooke
Jharna Datta
Kalpana Ghoshal
Pasit Phiasivongsa
Samson T Jacob
Sanjeev Redkar
Swarna A Gamage
William A Denny
P2860
P304
P356
10.1158/0008-5472.CAN-08-3669
P407
P577
2009-05-05T00:00:00Z