Topoisomerase 1 and single-strand break repair modulate transcription-induced CAG repeat contraction in human cells.
about
The histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulationRole of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesisGFP-based fluorescence assay for CAG repeat instability in cultured human cellsDHX9 helicase is involved in preventing genomic instability induced by alternatively structured DNA in human cellsXpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1.The DSIF subunits Spt4 and Spt5 have distinct roles at various phases of immunoglobulin class switch recombinationNucleotide excision repair, mismatch repair, and R-loops modulate convergent transcription-induced cell death and repeat instabilityDecrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation.Large expansion of CTG•CAG repeats is exacerbated by MutSβ in human cells.Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genesInstability of (CTG)n•(CAG)n trinucleotide repeats and DNA synthesisSemi-automated quantification of C9orf72 expansion size reveals inverse correlation between hexanucleotide repeat number and disease duration in frontotemporal degenerationContracting CAG/CTG repeats using the CRISPR-Cas9 nickase.Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instabilitySite-specific methylated reporter constructs for functional analysis of DNA methylation.Convergent transcription through microsatellite repeat tracts induces cell death.Repair of chromosomal double-strand breaks by precise ligation in human cells.SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair.Association of tyrosyl-DNA phosphodiesterase 1 polymorphism with Tourette syndrome in Taiwanese patients.Topoisomerase I and Genome Stability: The Good and the Bad.Characterization of Camptothecin-induced Genomic Changes in the Camptothecin-resistant T-ALL-derived Cell Line CPT-K5.Genetic instability associated with loop or stem-loop structures within transcription units can be independent of nucleotide excision repair.
P2860
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P2860
Topoisomerase 1 and single-strand break repair modulate transcription-induced CAG repeat contraction in human cells.
description
2011 nî lūn-bûn
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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年学术文章
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2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
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2011年學術文章
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name
Topoisomerase 1 and single-str ...... at contraction in human cells.
@ast
Topoisomerase 1 and single-str ...... at contraction in human cells.
@en
type
label
Topoisomerase 1 and single-str ...... at contraction in human cells.
@ast
Topoisomerase 1 and single-str ...... at contraction in human cells.
@en
prefLabel
Topoisomerase 1 and single-str ...... at contraction in human cells.
@ast
Topoisomerase 1 and single-str ...... at contraction in human cells.
@en
P2093
P2860
P356
P1476
Topoisomerase 1 and single-str ...... at contraction in human cells.
@en
P2093
John H Wilson
Leroy Hubert
Vincent Dion
P2860
P304
P356
10.1128/MCB.05158-11
P407
P577
2011-05-31T00:00:00Z