POT1-TPP1 regulates telomeric overhang structural dynamics. - Test2 - elhamkhani - TriplyDB

POT1-TPP1 regulates telomeric overhang structural dynamics.

POT1-TPP1 regulates telomeric overhang structural dynamics.

http://www.wikidata.org/entity/Q33944947

about

The lighthouse at the end of the chromosome Replication of Structured DNA and its implication in epigenetic stability Single-stranded DNA-binding proteins: multiple domains for multiple functions RNA Remodeling Activity of DEAD Box Proteins Tuned by Protein Concentration, RNA Length, and ATP RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase.Human telomerase: biogenesis, trafficking, recruitment, and activation.Single-molecule real-time detection of telomerase extension activity G-quadruplex conformation and dynamics are determined by loop length and sequence.Coordinated DNA dynamics during the human telomerase catalytic cycle.DNA and RNA quadruplex-binding proteins.Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding.Unraveling secrets of telomeres: one molecule at a time.Telomeric overhang length determines structural dynamics and accessibility to telomerase and ALT-associated proteins Diffusion of human replication protein A along single-stranded DNA.Molecular determinants of the interactions between proteins and ssDNA.Mutational Dissection of Telomeric DNA Binding Requirements of G4 Resolvase 1 Shows that G4-Structure and Certain 3'-Tail Sequences Are Sufficient for Tight and Complete Binding.ATP-dependent G-quadruplex unfolding by Bloom helicase exhibits low processivity.POT1-TPP1 Binding and Unfolding of Telomere DNA Discriminates against Structural Polymorphism.Tying up the Ends: Plasticity in the Recognition of Single-Stranded DNA at Telomeres.Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance.MTV, an ssDNA Protecting Complex Essential for Transposon-Based Telomere Maintenance in Drosophila Control of telomerase action at human telomeres DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation.Single molecule analysis of Thermus thermophilus SSB protein dynamics on single-stranded DNA Single-molecule studies reveal reciprocating of WRN helicase core along ssDNA during DNA unwinding.PTOP and TRF1 help enhance the radio resistance in breast cancer cell.5' to 3' Unfolding Directionality of DNA Secondary Structures by Replication Protein A: G-QUADRUPLEXES AND DUPLEXES A practical guide to studying G-quadruplex structures using single-molecule FRET.Telomerase Mechanism of Telomere Synthesis.DNA Replication Origins and Fork Progression at Mammalian Telomeres Single-Molecule Studies of Telomeres and Telomerase.A popular engagement at the ends.Folding dynamics and conformational heterogeneity of human telomeric G-quadruplex structures in Na+ solutions by single molecule FRET microscopy Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity.Mechanical unfolding of long human telomeric RNA (TERRA).Molecular mechanisms by which oxidative DNA damage promotes telomerase activity.Involvement of G-triplex and G-hairpin in the multi-pathway folding of human telomeric G-quadruplex.Dynamic DNA binding, junction recognition and G4 melting activity underlie the telomeric and genome-wide roles of human CST.

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P2860

POT1-TPP1 regulates telomeric overhang structural dynamics.

http://www.wikidata.org/entity/Q33944947

description

2012 nî lūn-bûn

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2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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POT1-TPP1 regulates telomeric overhang structural dynamics.

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POT1-TPP1 regulates telomeric overhang structural dynamics.

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POT1-TPP1 regulates telomeric overhang structural dynamics.

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POT1-TPP1 regulates telomeric overhang structural dynamics.

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POT1-TPP1 regulates telomeric overhang structural dynamics.

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POT1-TPP1 regulates telomeric overhang structural dynamics.

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POT1-TPP1 regulates telomeric overhang structural dynamics

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Helen Hwang

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Noah Buncher

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Sua Myong

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P2860

TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase

The POT1-TPP1 telomere complex is a telomerase processivity factor

PTOP interacts with POT1 and regulates its localization to telomeres

POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex

A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2

Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro

TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo

Pot1, the putative telomere end-binding protein in fission yeast and humans

Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex

Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection

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1872-1880

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Patricia L Opresko

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