PTOP interacts with POT1 and regulates its localization to telomeres
about
Human single-stranded DNA binding proteins are essential for maintaining genomic stabilityHOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitmentThe F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenanceHigher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assemblyProtein requirements for sister telomere association in human cellsTelosome, a mammalian telomere-associated complex formed by multiple telomeric proteinsGenome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cellsTelomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongationIn vivo stoichiometry of shelterin componentsOB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulationTelomere protection by mammalian Pot1 requires interaction with Tpp1POT1 association with TRF2 regulates telomere lengthHuman UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replicationCharacterization of the DNA binding specificity of Shelterin complexesHow the human telomeric proteins TRF1 and TRF2 recognize telomeric DNA: a view from high-resolution crystal structuresTelomere dysfunction and cell survival: roles for distinct TIN2-containing complexesHuman protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitroPOT1 and TRF2 cooperate to maintain telomeric integrityFinding the end: recruitment of telomerase to telomeresTIN2-tethered TPP1 recruits human telomerase to telomeres in vivoTelomere protection by TPP1 is mediated by POT1a and POT1bTINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenitaTelomere and Telomerase Therapeutics in CancerTelomere biology: Rationale for diagnostics and therapeutics in cancerTelomeres-structure, function, and regulationMultiple facets of TPP1 in telomere maintenanceHow telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNAThe shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7Switching human telomerase on and off with hPOT1 protein in vitroGenetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulationFunctional interaction between telomere protein TPP1 and telomeraseThe TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivityStructure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protectionPOT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombinationTelomere- and telomerase-interacting protein that unfolds telomere G-quadruplex and promotes telomere extension in mammalian cellsCurrent aging research in China.POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation.Multiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA.Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance.
P2860
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P248
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P2860
PTOP interacts with POT1 and regulates its localization to telomeres
description
2004 nî lūn-bûn
@nan
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
PTOP interacts with POT1 and regulates its localization to telomeres
@ast
PTOP interacts with POT1 and regulates its localization to telomeres
@en
PTOP interacts with POT1 and regulates its localization to telomeres
@en-gb
PTOP interacts with POT1 and regulates its localization to telomeres
@nl
type
label
PTOP interacts with POT1 and regulates its localization to telomeres
@ast
PTOP interacts with POT1 and regulates its localization to telomeres
@en
PTOP interacts with POT1 and regulates its localization to telomeres
@en-gb
PTOP interacts with POT1 and regulates its localization to telomeres
@nl
prefLabel
PTOP interacts with POT1 and regulates its localization to telomeres
@ast
PTOP interacts with POT1 and regulates its localization to telomeres
@en
PTOP interacts with POT1 and regulates its localization to telomeres
@en-gb
PTOP interacts with POT1 and regulates its localization to telomeres
@nl
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P2860
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PTOP interacts with POT1 and regulates its localization to telomeres
@en
P2093
Amin Safari
Andrew Laegeler
Doug W Chan
Matthew S O'Connor
Zhou Songyang
P2860
P2888
P304
P3181
P356
10.1038/NCB1142
P407
P577
2004-07-01T00:00:00Z
P5875
P6179
1043226450