Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites. - Test2 - elhamkhani - TriplyDB

Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites.

Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites.

http://www.wikidata.org/entity/Q33964823

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Insights into novel antimicrobial compounds and antibiotic resistance genes from soil metagenomes Microbiome analysis - from technical advances to biological relevance Biocatalysts and small molecule products from metagenomic studies Actinomycetes from the South China Sea sponges: isolation, diversity, and potential for aromatic polyketides discovery Emerging strategies and integrated systems microbiology technologies for biodiscovery of marine bioactive compounds.Environmental DNA-encoded antibiotics fasamycins A and B inhibit FabF in type II fatty acid biosynthesis Natural product biosynthetic gene diversity in geographically distinct soil microbiomes.Meta-omic characterization of prokaryotic gene clusters for natural product biosynthesis.Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors Mining soil metagenomes to better understand the evolution of natural product structural diversity: pentangular polyphenols as a case study.The Biogeography of Putative Microbial Antibiotic Production.Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist Reinvigorating natural product combinatorial biosynthesis with synthetic biology Genomes to natural products PRediction Informatics for Secondary Metabolomes (PRISM)"Cre/loxP plus BAC": a strategy for direct cloning of large DNA fragment and its applications in Photorhabdus luminescens and Agrobacterium tumefaciens.Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A.Biotechnology of polyketides: new breath of life for the novel antibiotic genetic pathways discovery through metagenomics Metagenomics and novel gene discovery: promise and potential for novel therapeutics.The role of transcription in heterologous expression of polyketides in bacterial hosts.Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides.Culture-independent discovery of natural products from soil metagenomes.Formicamycins, antibacterial polyketides produced by Streptomyces formicae isolated from African Tetraponera plant-ants.Transformation-associated recombination (TAR) cloning for genomics studies and synthetic biology.Phylogeny-guided (meta)genome mining approach for the targeted discovery of new microbial natural products.Sampling Terrestrial Environments for Bacterial Polyketides.Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. I. The taxonomy of the producing strain, and the fermentation, isolation and antibacterial activities.Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. II. Structure elucidation.Total synthesis of (±)-naphthacemycin A9, possessing both antibacterial activity against methicillin-resistant Staphylococcus aureus and circumventing effect of β-lactam resistance.Arixanthomycins A-C: Phylogeny-guided discovery of biologically active eDNA-derived pentangular polyphenols Natural Product Discovery through Improved Functional Metagenomics in Streptomyces.Tetarimycin A, an MRSA-active antibiotic identified through induced expression of environmental DNA gene clusters.Generate a bioactive natural product library by mining bacterial cytochrome P450 patterns.Bacterial natural product biosynthetic domain composition in soil correlates with changes in latitude on a continent-wide scale.Rational engineering of Streptomyces albus J1074 for the overexpression of secondary metabolite gene clusters.Involvement of the Baeyer-Villiger Monooxygenase IfnQ in the Biosynthesis of Isofuranonaphthoquinone Scaffold of JBIR-76 and -77.Tafuketide, a phylogeny-guided discovery of a new polyketide from Talaromyces funiculosus Salicorn 58.Concepts and Methods to Access Novel Antibiotics from Actinomycetes.Synthetic Biology of Antibiotic Production

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P2860

Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites.

http://www.wikidata.org/entity/Q33964823

description

2011 nî lūn-bûn

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2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2011 թվականի հուլիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Functional analysis of environ ...... diverse secondary metabolites.

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Proceedings of the National Academy of Sciences of the United States of America

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Functional analysis of environ ...... diverse secondary metabolites.

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Dimitris Kallifidas

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Sean F Brady

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Zhiyang Feng

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P2860

The Uncultured Microbial Majority

Identification of unique type II polyketide synthase genes in soil

Antibacterial natural products in medicinal chemistry--exodus or revival?

Biogeography of actinomycete communities and type II polyketide synthase genes in soils collected in New Jersey and Central Asia

Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus

Molecular evolution of aromatic polyketides and comparative sequence analysis of polyketide ketosynthase and 16S ribosomal DNA genes from various streptomyces species.

Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

Marcel Faber Roundtable: is our antibiotic pipeline unproductive because of starvation, constipation or lack of inspiration?

Construction of soil environmental DNA cosmid libraries and screening for clones that produce biologically active small molecules.

Specific cloning of human DNA as yeast artificial chromosomes by transformation-associated recombination

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12629-12634

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108

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