Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration. - Test2 - elhamkhani - TriplyDB

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.

http://www.wikidata.org/entity/Q33991769

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The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration The retromer complex in development and disease A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex Vacuolar Protein Sorting Genes in Parkinson's Disease: A Re-appraisal of Mutations Detection Rate and Neurobiology of Disease Mitochondrial Biology and Neurological Diseases Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes Retromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in Drosophila VPS35 regulates cell surface recycling and signaling of dopamine receptor D1 Familial atypical parkinsonism with rare variant in VPS35 and FBXO7 genes: A case report.VPS35, the Retromer Complex and Parkinson's Disease.VPS35 regulates parkin substrate AIMP2 toxicity by facilitating lysosomal clearance of AIMP2.High expression levels of the D686N Parkinson's disease mutation in VPS35 induces α-synuclein-dependent toxicity in yeast In vivo evidence of pathogenicity of VPS35 mutations in the Drosophila.The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation.Impaired intracellular trafficking defines early Parkinson's disease Genes associated with Parkinson's disease: regulation of autophagy and beyond.Endocytic membrane trafficking and neurodegenerative disease.Insulin-Like Growth Factor-II/Cation-Independent Mannose 6-Phosphate Receptor in Neurodegenerative Diseases.Molecular changes in the postmortem parkinsonian brain.Defects in trafficking bridge Parkinson's disease pathology and genetics.Rabs, Membrane Dynamics, and Parkinson's Disease.The emerging role of retromer in neuroprotection.VPS35 pathogenic mutations confer no dominant toxicity but partial loss of function in Drosophila and genetically interact with parkin.Genetic variability of the retromer cargo recognition complex in parkinsonism.Vps35-deficiency impairs SLC4A11 trafficking and promotes corneal dystrophy.VPS35 Parkinson mutation impairs autophagy via WASH.Mitochondria: A Common Target for Genetic Mutations and Environmental Toxicants in Parkinson's Disease.Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.Reduced LRRK2 in association with retromer dysfunction in post-mortem brain tissue from LRRK2 mutation carriers.Convergent pathways in Parkinson's disease.Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila.Impaired striatal dopamine release in homozygous Vps35 D620N knock-in mice.The Dopamine Transporter Recycles via a Retromer-Dependent Postendocytic Mechanism: Tracking Studies Using a Novel Fluorophore-Coupling Approach.Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p.D620N.VPS35 depletion does not impair presynaptic structure and function.The Retromer Complex and Sorting Nexins in Neurodegenerative Diseases.Parkinson Disease from Mendelian Forms to Genetic Susceptibility: New Molecular Insights into the Neurodegeneration Process.Retrograde trafficking from the endosome to the trans-Golgi network mediated by the retromer is required for fungal development and pathogenicity in Fusarium graminearum.VPS29-VPS35 intermediate of retromer is stable and may be involved in the retromer complex assembly process.

P2860

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P2860

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.

http://www.wikidata.org/entity/Q33991769

description

2014 nî lūn-bûn

@nan

2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի ապրիլին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.

@ast

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.

@en

type

label

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.

@ast

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.

@en

prefLabel

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.

@ast

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.

@en

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Human Molecular Genetics

P1476

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.

@en

P2093

Andrew Lees

http://www.w3.org/2001/XMLSchema#string

Guillaume Daniel

http://www.w3.org/2001/XMLSchema#string

Juan C Troncoso

http://www.w3.org/2001/XMLSchema#string

Liliane Glauser

http://www.w3.org/2001/XMLSchema#string

Rina Bandopadhyay

http://www.w3.org/2001/XMLSchema#string

Roger Moser

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Una-Marie Sheerin

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P2860

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk

GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer

A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease

Genome-wide association study reveals genetic risk underlying Parkinson's disease

Functional architecture of the retromer cargo-recognition complex

A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast

Alpha-synuclein in Lewy bodies

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4621-4638

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scholarly article

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10.1093/HMG/DDU178

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17

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23

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Bernard L. Schneider

Patrick A. Lewis

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2014-04-15T00:00:00Z

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261752138

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24740878

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Parkinson's disease

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4119414

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