Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.
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The endosomal-lysosomal system: from acidification and cargo sorting to neurodegenerationThe retromer complex in development and diseaseA molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complexVacuolar Protein Sorting Genes in Parkinson's Disease: A Re-appraisal of Mutations Detection Rate and Neurobiology of DiseaseMitochondrial Biology and Neurological DiseasesParkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexesRetromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in DrosophilaVPS35 regulates cell surface recycling and signaling of dopamine receptor D1Familial atypical parkinsonism with rare variant in VPS35 and FBXO7 genes: A case report.VPS35, the Retromer Complex and Parkinson's Disease.VPS35 regulates parkin substrate AIMP2 toxicity by facilitating lysosomal clearance of AIMP2.High expression levels of the D686N Parkinson's disease mutation in VPS35 induces α-synuclein-dependent toxicity in yeastIn vivo evidence of pathogenicity of VPS35 mutations in the Drosophila.The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation.Impaired intracellular trafficking defines early Parkinson's diseaseGenes associated with Parkinson's disease: regulation of autophagy and beyond.Endocytic membrane trafficking and neurodegenerative disease.Insulin-Like Growth Factor-II/Cation-Independent Mannose 6-Phosphate Receptor in Neurodegenerative Diseases.Molecular changes in the postmortem parkinsonian brain.Defects in trafficking bridge Parkinson's disease pathology and genetics.Rabs, Membrane Dynamics, and Parkinson's Disease.The emerging role of retromer in neuroprotection.VPS35 pathogenic mutations confer no dominant toxicity but partial loss of function in Drosophila and genetically interact with parkin.Genetic variability of the retromer cargo recognition complex in parkinsonism.Vps35-deficiency impairs SLC4A11 trafficking and promotes corneal dystrophy.VPS35 Parkinson mutation impairs autophagy via WASH.Mitochondria: A Common Target for Genetic Mutations and Environmental Toxicants in Parkinson's Disease.Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.Reduced LRRK2 in association with retromer dysfunction in post-mortem brain tissue from LRRK2 mutation carriers.Convergent pathways in Parkinson's disease.Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila.Impaired striatal dopamine release in homozygous Vps35 D620N knock-in mice.The Dopamine Transporter Recycles via a Retromer-Dependent Postendocytic Mechanism: Tracking Studies Using a Novel Fluorophore-Coupling Approach.Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p.D620N.VPS35 depletion does not impair presynaptic structure and function.The Retromer Complex and Sorting Nexins in Neurodegenerative Diseases.Parkinson Disease from Mendelian Forms to Genetic Susceptibility: New Molecular Insights into the Neurodegeneration Process.Retrograde trafficking from the endosome to the trans-Golgi network mediated by the retromer is required for fungal development and pathogenicity in Fusarium graminearum.VPS29-VPS35 intermediate of retromer is stable and may be involved in the retromer complex assembly process.
P2860
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P2860
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.
description
2014 nî lūn-bûn
@nan
2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.
@ast
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.
@en
type
label
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.
@ast
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.
@en
prefLabel
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.
@ast
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.
@en
P2093
P2860
P50
P356
P1476
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.
@en
P2093
Andrew Lees
Guillaume Daniel
Juan C Troncoso
Liliane Glauser
Rina Bandopadhyay
Roger Moser
Una-Marie Sheerin
P2860
P304
P356
10.1093/HMG/DDU178
P577
2014-04-15T00:00:00Z